BSD2_YEAST - dbPTM
BSD2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BSD2_YEAST
UniProt AC P38356
Protein Name Metal homeostatis protein BSD2
Gene Name BSD2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 321
Subcellular Localization Endoplasmic reticulum. Vacuole. Membrane
Multi-pass membrane protein.
Protein Description Required for homeostasis of heavy metal ions such as cadmium, cobalt and copper. Controls metal ion transport and prevents metal hyperaccumulation by negatively regulating the SMF1 and SMF2 metal transport systems. Under manganese-replete conditions facilitates trafficking of SMF1 and SMF2 metal transporters to the vacuole where they are degraded..
Protein Sequence MPEQELLIGQEMNTLHAGSSTDGINVGNAGRTRDTQTGVEGETEIGSDEEDSIEDEGSSSGGNSTTERLVPHQLREQAARHIGKIGRHFNILDRLFKKRTQQSSDIQQGAMFDGVFSNLSAKPDTTETEGNNEQDIPPTYDEAAADMAPSYYGMDLNNSDIYYDEICIEGLPVGNIANLLWNIIVSTSFQFIGFLITYILHTSHAAKQGSRFGLGLTFIGYGYSMIPNDVTSKVGKNKSLNRMELEDPNEFDDVRLNSQSTTQDKFESHLNHGLDEEKQNIPWLAVFVAFLGLFITLKSIYDYIQVKKLEKKYLNQSQNQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationTLHAGSSTDGINVGN
CCCCCCCCCCCCCCC		39.6828889911
47PhosphorylationEGETEIGSDEEDSIE
CCEEECCCCCCCCCC		47.7321440633
307UbiquitinationIYDYIQVKKLEKKYL
HHHHHHHHHHHHHHH		34.9522817900
308UbiquitinationYDYIQVKKLEKKYLN
HHHHHHHHHHHHHHH		64.1222817900
311UbiquitinationIQVKKLEKKYLNQSQ
HHHHHHHHHHHHHHH		58.0922817900
312UbiquitinationQVKKLEKKYLNQSQN
HHHHHHHHHHHHHHC		45.6623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BSD2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BSD2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SMF1_YEASTSMF1genetic
9115231
SMF2_YEASTSMF2genetic
9115231
TUL1_YEASTTUL1genetic
14988731
RER1_YEASTRER1genetic
14988731
INO2_YEASTINO2genetic
8725219
PER1_YEASTPER1genetic
16269340
ATC1_YEASTPMR1genetic
16269340
PFD2_YEASTGIM4genetic
16269340
ERG4_YEASTERG4genetic
16269340
GUP1_YEASTGUP1genetic
16269340
MTC4_YEASTMTC4genetic
16269340
PKR1_YEASTPKR1genetic
16269340
ORM2_YEASTORM2genetic
16269340
GET2_YEASTGET2genetic
16269340
COPE_YEASTSEC28genetic
16269340
SCS7_YEASTSCS7genetic
16269340
SMF1_YEASTSMF1genetic
18973803
PIB1_YEASTPIB1genetic
19912579
VPS4_YEASTVPS4genetic
19369420
CARP_YEASTPEP4genetic
19369420
ATG1_YEASTATG1genetic
19369420
AP3M_YEASTAPM3genetic
19369420
VPS36_YEASTVPS36genetic
19369420
SNF7_YEASTSNF7genetic
19369420
STP22_YEASTSTP22genetic
19369420
VPS21_YEASTVPS21genetic
19369420
PEP12_YEASTPEP12genetic
19369420
VPS27_YEASTVPS27genetic
19369420
END3_YEASTEND3genetic
19369420
VPS45_YEASTVPS45genetic
19369420
LDS1_YEASTLDS1physical
16093310
PHO88_YEASTPHO88physical
16093310
ALG1_YEASTALG1physical
16093310
MKAR_YEASTIFA38physical
16093310
YPC1_YEASTYPC1physical
16093310
PBN1_YEASTPBN1physical
16093310
ADP1_YEASTADP1physical
16093310
PMP1_YEASTPMP1physical
16093310
ELO2_YEASTELO2physical
16093310
TECR_YEASTTSC13physical
16093310
SHR3_YEASTSHR3physical
16093310
SUR2_YEASTSUR2physical
16093310
ANP1_YEASTANP1physical
16093310
ERG4_YEASTERG4physical
16093310
MST27_YEASTMST27physical
16093310
ERV29_YEASTERV29physical
16093310
NSG1_YEASTNSG1physical
16093310
SNL1_YEASTSNL1physical
16093310
VDAC2_YEASTPOR2physical
16093310
PHO86_YEASTPHO86physical
16093310
ELO1_YEASTELO1physical
16093310
STE24_YEASTSTE24physical
16093310
LAC1_YEASTLAC1physical
16093310
YET1_YEASTYET1physical
16093310
THI73_YEASTTHI73physical
16093310
POM34_YEASTPOM34physical
16093310
ELO3_YEASTELO3physical
16093310
GSF2_YEASTGSF2physical
16093310
GAS3_YEASTGAS3physical
16093310
ERP4_YEASTERP4physical
16093310
GPI2_YEASTGPI2physical
16093310
YDC1_YEASTYDC1physical
16093310
COX11_YEASTCOX11physical
16093310
ALG5_YEASTALG5physical
16093310
YOP1_YEASTYOP1physical
16093310
TPO3_YEASTTPO3physical
16093310
RER1_YEASTRER1genetic
17932044
SMF1_YEASTSMF1genetic
15166140
SRS2_YEASTSRS2genetic
21459050
HSP71_YEASTSSA1physical
22940862
HSP72_YEASTSSA2physical
22940862
SLA1_YEASTSLA1genetic
23891562
SAC7_YEASTSAC7genetic
23891562
ATC1_YEASTPMR1genetic
23891562
MNN11_YEASTMNN11genetic
23891562
VAM7_YEASTVAM7genetic
23891562
AP3B_YEASTAPL6genetic
23891562
VPH1_YEASTVPH1genetic
23891562
GET2_YEASTGET2genetic
23891562
GLO3_YEASTGLO3genetic
23891562
PACC_YEASTRIM101genetic
23891562
PALF_YEASTRIM8genetic
23891562
PALH_YEASTRIM21genetic
23891562
ELO3_YEASTELO3genetic
23891562
SUR1_YEASTSUR1genetic
23891562
TRE1_YEASTTRE1genetic
16456538
TRE2_YEASTTRE2genetic
16456538
RSP5_YEASTRSP5physical
23443663
UBP13_YEASTUBP13genetic
27708008
SODM_YEASTSOD2genetic
27708008
SCS7_YEASTSCS7genetic
27708008
PUR1_YEASTADE4genetic
27708008
AP1G1_YEASTAPL4genetic
27708008
SLA1_YEASTSLA1genetic
27708008
ETR1_YEASTETR1genetic
27708008
YCA2_YEASTYCL002Cgenetic
27708008
RV161_YEASTRVS161genetic
27708008
PAT1_YEASTPAT1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
NRG1_YEASTNRG1genetic
27708008
SWF1_YEASTSWF1genetic
27708008
RPA14_YEASTRPA14genetic
27708008
PMP3_YEASTPMP3genetic
27708008
SAC7_YEASTSAC7genetic
27708008
DIT1_YEASTDIT1genetic
27708008
CEM1_YEASTCEM1genetic
27708008
MSH4_YEASTMSH4genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
RL26B_YEASTRPL26Bgenetic
27708008
VMA21_YEASTVMA21genetic
27708008
MAL12_YEASTMAL12genetic
27708008
OPI1_YEASTOPI1genetic
27708008
FKH1_YEASTFKH1genetic
27708008
ATG32_YEASTATG32genetic
27708008
RPA34_YEASTRPA34genetic
27708008
EMC6_YEASTEMC6genetic
27708008
UBI4P_YEASTUBI4genetic
27708008
ATG10_YEASTATG10genetic
27708008
ADY4_YEASTADY4genetic
27708008
CHS5_YEASTCHS5genetic
27708008
RS29A_YEASTRPS29Agenetic
27708008
SUR7_YEASTSUR7genetic
27708008
AIM34_YEASTAIM34genetic
27708008
FET3_YEASTFET3genetic
27708008
PALI_YEASTRIM9genetic
27708008
PKR1_YEASTPKR1genetic
27708008
RIM13_YEASTRIM13genetic
27708008
ATG16_YEASTATG16genetic
27708008
MKT1_YEASTMKT1genetic
27708008
PFD4_YEASTGIM3genetic
27708008
RCF2_YEASTRCF2genetic
27708008
ARE2_YEASTARE2genetic
27708008
IZH2_YEASTIZH2genetic
27708008
MSN1_YEASTMSN1genetic
27708008
CHL1_YEASTCHL1genetic
27708008
SKS1_YEASTSKS1genetic
27708008
PCL8_YEASTPCL8genetic
27708008
FUMH_YEASTFUM1genetic
27708008
CSR2_YEASTCSR2genetic
27708008
YP078_YEASTYPR078Cgenetic
27708008
ATG13_YEASTATG13genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BSD2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-312, AND MASSSPECTROMETRY.

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