THI73_YEAST - dbPTM
THI73_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THI73_YEAST
UniProt AC Q07904
Protein Name Thiamine pathway transporter THI73
Gene Name THI73
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 523
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein .
Protein Description Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway..
Protein Sequence MKNMSQRSMDVEKKAANADSCSVSTSSINVDDADVALRFLKQNGLDESSTANEDDVVAGEEANFYGSHELSPKVLRKVDLFILPFLCCTYLLMFLDKALLNYAASMGIKDHLKGNEFSNLGTIFSAAYIFMEPVVTYLIQKFPISKILGTFITVWGIVLACHAACKTYASLMVVRTLLGLFESSSAVGCIAISGMYYTKSEQSARIGFWATQAGTGYIVGGLISFGFLHYHGTAFTSWQIMFLVVGLVTVAFGVLTFLYLPDNVTNAWFLNKEEKIQVVEHIRANQTGLETKKFKKQQVKELFLHDKFTWPMLLLTACSQISTGAIGTFSVTITGTFGFDKYETALLQLPIGAITAMIILITTQMLSRWGHITLITTSMYIPAIIGCIVLISLPLSHKIGNLFSLYLLYSGSCVITNIYIWNSCNTSGYTKRVFRNAITMIVYNVSCIIAPQMFRAYSAPRYIPAKIALLVTQCVCVPLQLYIGYICKKENEKRDKEQEGQERKKYQFLDLTDIENRNFRYIY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationKKAANADSCSVSTSS
HHHCCCCCCEEECCC		13.0921440633
22PhosphorylationAANADSCSVSTSSIN
HCCCCCCEEECCCCC		24.0521440633
27PhosphorylationSCSVSTSSINVDDAD
CCEEECCCCCCCCHH		20.4721440633
48PhosphorylationKQNGLDESSTANEDD
HHCCCCCCCCCCCCC		32.4328889911
49PhosphorylationQNGLDESSTANEDDV
HCCCCCCCCCCCCCC		29.5028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THI73_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THI73_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THI73_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHEB_YEASTRHB1genetic
20093466
RL35A_YEASTRPL35Agenetic
20093466
RL35B_YEASTRPL35Agenetic
20093466
INM2_YEASTINM2genetic
20093466
LCMT1_YEASTPPM1genetic
20093466
MIC19_YEASTMIC19genetic
20093466
RS27B_YEASTRPS27Bgenetic
20093466
SET2_YEASTSET2genetic
20093466
EOS1_YEASTEOS1genetic
20093466
BUD21_YEASTBUD21genetic
20093466
MED1_YEASTMED1genetic
20093466
MKAR_YEASTIFA38physical
16093310
ELO3_YEASTELO3physical
16093310
SSB1_YEASTSSB1physical
22940862
HSP72_YEASTSSA2physical
22940862
DED1_YEASTDED1physical
22940862
HSP71_YEASTSSA1physical
22940862
RAD55_YEASTRAD55genetic
27708008
INM2_YEASTINM2genetic
27708008
PMT7_YEASTPMT7genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
EOS1_YEASTEOS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THI73_YEAST

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Related Literatures of Post-Translational Modification

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