| UniProt ID | VPS45_YEAST | |
|---|---|---|
| UniProt AC | P38932 | |
| Protein Name | Vacuolar protein sorting-associated protein 45 | |
| Gene Name | VPS45 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 577 | |
| Subcellular Localization |
Cytoplasm . Vacuole membrane Peripheral membrane protein Cytoplasmic side . Cycles between the cytoplasmic side of the vacuolar membrane and the cytoplasm. |
|
| Protein Description | Essential for vacuolar protein sorting. Function in membrane traffic between the Golgi and the vacuole.. | |
| Protein Sequence | MNLFDVADFYINKIVTSQSKLSVANVNEHQRIKVLLLDKNTTPTISLCATQSELLKHEIYLVERIENEQREVSRHLRCLVYVKPTEETLQHLLRELRNPRYGEYQIFFSNIVSKSQLERLAESDDLEAVTKVEEIFQDFFILNQDLFSFDLQPREFLSNKLVWSEGGLTKCTNSLVSVLLSLKIKPDIRYEGASKICERLAKEVSYEIGKNERTFFDFPVMDSTPVLLILDRNTDPITPLLQPWTYQSMINEYIGIKRNIVDLSKVPRIDKDLEKVTLSSKQDAFFRDTMYLNFGELGDKVKQYVTTYKDKTQTNSQINSIEDIKNFIEKYPEFRKLSGNVAKHMAIVGELDRQLKIKNIWEISEIEQNLSAHDANEEDFSDLIKLLQNEAVDKYYKLKLACIYSLNNQTSSDKIRQLVEILSQQLPPEDVNFFHKFKSLFSRQDKMTQSNHDKDDILTELARRFNSRMNSKSNTAENVYMQHIPEISSLLTDLSKNALFRDRFKEIDTQGHRVIGNQQSKDIPQDVILFVIGGVTYEEARLVHDFNGTMNNRMRVVLGGTSILSTKEYMDSIRSAK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Ubiquitination | KIVTSQSKLSVANVN CHHCCCCCCCCCCCC | 36.82 | 23749301 | |
| 275 | Acetylation | RIDKDLEKVTLSSKQ CCCCCHHHCCCCCHH | 48.06 | 24489116 | |
| 311 | Ubiquitination | YVTTYKDKTQTNSQI HHHHCCCCCCCHHHC | 38.08 | 23749301 | |
| 330 | Ubiquitination | DIKNFIEKYPEFRKL HHHHHHHHCHHHHHH | 62.38 | 24961812 | |
| 414 | Ubiquitination | NNQTSSDKIRQLVEI CCCCCHHHHHHHHHH | 41.56 | 23749301 | |
| 438 | Acetylation | VNFFHKFKSLFSRQD CCHHHHHHHHHHHHH | 51.56 | 24489116 | |
| 454 | Acetylation | MTQSNHDKDDILTEL HHCCCCCHHHHHHHH | 50.15 | 24489116 | |
| 496 | Ubiquitination | SLLTDLSKNALFRDR HHHHHHCCCHHHHHH | 54.24 | 23749301 | |
| 566 | Phosphorylation | GGTSILSTKEYMDSI CCCCHHCCHHHHHHH | 25.17 | 27017623 | |
| 572 | Phosphorylation | STKEYMDSIRSAK-- CCHHHHHHHHHCC-- | 11.90 | 17287358 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS45_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS45_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS45_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-572, AND MASSSPECTROMETRY. | |
