TDA3_YEAST - dbPTM
TDA3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TDA3_YEAST
UniProt AC P38758
Protein Name Putative oxidoreductase TDA3
Gene Name TDA3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 523
Subcellular Localization Cytoplasm. Late endosome. The recruitment from the cytoplasm to endosomal structures is facilitated by BTN2.
Protein Description Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi. Regulates YIF1 and KEX2 localization. Required for fast DNA replication..
Protein Sequence MGEDFMHPPFQTYPSKNSEGKKHIVIVGGGIIGCCTAYYLTQHPSFSPSTHHITIIESRRIAGGASGKAGGLLASWAFPHQIVPLSFQLHQELSDEYDGENNWDYRRLTTVSLEADVREEVIENYERLSKKAYNLNVPPPKKRPGYISNKFNIGDSNSSLSSSGSSLKNDSASNEEEGSDIHVSSSVPSLHSLTNERMRSHTNSASDLDSVSPVEQLRETNIHNPLPADLDWIRRELVNDWSSLGGTDTTAQLHPYKFTHFILSKAMETGAVDLLLGKVVGLKCDEMDCVHSLKYLPSVVKNRRNSRGHAENPDIKLGTIFNDENAKPIEINDIQQIVLSMGPWTSKILKDCPISGLRAHSVTIKPSEKTVSPYAILAELKVNDREFFSPEMYARKDEVYVCGEGDTLVNIPESSDDVEVVSEKCDELYHYVSKLSPTLSKGHLLRKQACFLPVLNVPTSSGPLIGETNVKDLYIASGHSCWGINNAPATGKLMAEILLDGEATSAEISSLDPKLYFDATILS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
131AcetylationNYERLSKKAYNLNVP
HHHHHHHHHHCCCCC		53.3725381059
150AcetylationRPGYISNKFNIGDSN
CCCCCCCCCCCCCCC		32.7522865919
156PhosphorylationNKFNIGDSNSSLSSS
CCCCCCCCCCCCCCC		33.1422890988
158PhosphorylationFNIGDSNSSLSSSGS
CCCCCCCCCCCCCCC		36.2922890988
159PhosphorylationNIGDSNSSLSSSGSS
CCCCCCCCCCCCCCC		36.2022369663
161PhosphorylationGDSNSSLSSSGSSLK
CCCCCCCCCCCCCCC		25.1422890988
162PhosphorylationDSNSSLSSSGSSLKN
CCCCCCCCCCCCCCC		43.9722890988
163PhosphorylationSNSSLSSSGSSLKND
CCCCCCCCCCCCCCC		39.0422890988
165PhosphorylationSSLSSSGSSLKNDSA
CCCCCCCCCCCCCCC		34.1522890988
166PhosphorylationSLSSSGSSLKNDSAS
CCCCCCCCCCCCCCC		47.0622890988
171PhosphorylationGSSLKNDSASNEEEG
CCCCCCCCCCCCCCC		42.8822369663
173PhosphorylationSLKNDSASNEEEGSD
CCCCCCCCCCCCCCC		49.0422369663
179PhosphorylationASNEEEGSDIHVSSS
CCCCCCCCCCEECCC		36.3522369663
184PhosphorylationEGSDIHVSSSVPSLH
CCCCCEECCCCCCHH		11.6122369663
185PhosphorylationGSDIHVSSSVPSLHS
CCCCEECCCCCCHHH		33.9822369663
186PhosphorylationSDIHVSSSVPSLHSL
CCCEECCCCCCHHHH		30.4622369663
189PhosphorylationHVSSSVPSLHSLTNE
EECCCCCCHHHHCHH		36.2422369663
192PhosphorylationSSVPSLHSLTNERMR
CCCCCHHHHCHHHHH		42.0322369663
194PhosphorylationVPSLHSLTNERMRSH
CCCHHHHCHHHHHHH		37.7422369663
200PhosphorylationLTNERMRSHTNSASD
HCHHHHHHHCCCCHH		25.8922369663
202PhosphorylationNERMRSHTNSASDLD
HHHHHHHCCCCHHHC		31.9222369663
204PhosphorylationRMRSHTNSASDLDSV
HHHHHCCCCHHHCCC		30.2422369663
206PhosphorylationRSHTNSASDLDSVSP
HHHCCCCHHHCCCCH		38.2322369663
210PhosphorylationNSASDLDSVSPVEQL
CCCHHHCCCCHHHHH		31.6222369663
212PhosphorylationASDLDSVSPVEQLRE
CHHHCCCCHHHHHHH		27.4622369663
220PhosphorylationPVEQLRETNIHNPLP
HHHHHHHCCCCCCCC		32.7927017623
306PhosphorylationVVKNRRNSRGHAENP
HHHCCCCCCCCCCCC		37.5217287358
369AcetylationVTIKPSEKTVSPYAI
EEECCCCCCCCCCEE		59.5724489116
372PhosphorylationKPSEKTVSPYAILAE
CCCCCCCCCCEEEEE		19.8821440633
436PhosphorylationYHYVSKLSPTLSKGH
HHHHHHHCCCCCCCC		21.4121440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TDA3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TDA3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TDA3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VTS1_YEASTVTS1physical
11283351
SSB1_YEASTSSB1physical
19536198
BTN2_YEASTBTN2genetic
21441304
HSP72_YEASTSSA2physical
22940862
SSB1_YEASTSSB1physical
22940862
TDA3_YEASTTDA3physical
22940862
BTN2_YEASTBTN2physical
25512335
PMP3_YEASTPMP3genetic
27708008
RTG2_YEASTRTG2genetic
27708008
ERG3_YEASTERG3genetic
27708008
VRP1_YEASTVRP1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
IRA2_YEASTIRA2genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
NAA30_YEASTMAK3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TDA3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158; SER-159; SER-184;SER-200; THR-202; SER-204; SER-206; SER-210 AND SER-212, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; THR-202; SER-204;SER-206 AND SER-212, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, AND MASSSPECTROMETRY.

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