dbPTM

ERD2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ERD2_YEAST
UniProt AC	P18414
Protein Name	ER lumen protein-retaining receptor
Gene Name	ERD2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	219
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein.
Protein Description	Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor strongly recognizes H-D-E-L and weakly recognizes D-D-E-L and K-D-E-L..
Protein Sequence	MNPFRILGDLSHLTSILILIHNIKTTRYIEGISFKTQTLYALVFITRYLDLLTFHWVSLYNALMKIFFIVSTAYIVVLLQGSKRTNTIAYNEMLMHDTFKIQHLLIGSALMSVFFHHKFTFLELAWSFSVWLESVAILPQLYMLSKGGKTRSLTVHYIFAMGLYRALYIPNWIWRYSTEDKKLDKIAFFAGLLQTLLYSDFFYIYYTKVIRGKGFKLPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
33	Phosphorylation	TRYIEGISFKTQTLY CCCCCCCCCHHHHHH	31.39	15665377
176	Phosphorylation	IPNWIWRYSTEDKKL CCCCHHHCCCCCCCH	12.63	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ERD2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ERD2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ERD2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPM1_YEAST	DPM1	genetic	1327759
SEC12_YEAST	SEC12	genetic	1327759
SED1_YEAST	SED1	genetic	1327759
SED4_YEAST	SED4	genetic	1327759
SED5_YEAST	SED5	genetic	1400588
PFD4_YEAST	GIM3	genetic	16269340
GEA2_YEAST	GEA2	genetic	16269340
PFD2_YEAST	GIM4	genetic	16269340

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ERD2_YEAST

Related Literatures of Post-Translational Modification