| UniProt ID | NOT1_YEAST | |
|---|---|---|
| UniProt AC | P25655 | |
| Protein Name | General negative regulator of transcription subunit 1 | |
| Gene Name | CDC39 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 2108 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.. | |
| Protein Sequence | MLSATYRDLNTASNLETSKEKQAAQIVIAQISLLFTTLNNDNFESVEREIRHILDRSSVDIYIKVWERLLTLSSRDILQAGKFLLQENLLHRLLLEFAKDLPKKSTDLIELLKERTFNNQEFQKQTGITLSLFIDLFDKSANKDIIESLDRSSQINDFKTIKMNHTNYLRNFFLQTTPETLESNLRDLLHSLEGESLNDLLALLLSEILSPGSQNLQNDPTRSWLTPPMVLDATNRGNVIARSISSLQANQINWNRVFNLMSTKYFLSAPLMPTTASLSCLFAALHDGPVIDEFFSCDWKVIFKLDLAIQLHKWSVQNGCFDLLNAEGTRKVSETIPNTKQSLLYLLSIASLNLELFLQREELSDGPMLAYFQECFFEDFNYAPEYLILALVKEMKRFVLLIENRTVIDEILITLLIQVHNKSPSSFKDVISTITDDSKIVDAAKIIINSDDAPIANFLKSLLDTGRLDTVINKLPFNEAFKILPCARQIGWEGFDTFLKTKVSPSNVDVVLESLEVQTKMTDTNTPFRSLKTFDLFAFHSLIEVLNKCPLDVLQLQRFESLEFSLLIAFPRLINFGFGHDEAILANGDIAGINNDIEKEMQNYLQKMYSGELAIKDVIELLRRLRDSDLPRDQEVFTCITHAVIAESTFFQDYPLDALATTSVLFGSMILFQLLRGFVLDVAFRIIMRFAKEPPESKMFKFAVQAIYAFRIRLAEYPQYCKDLLRDVPALKSQAQVYQSIVEAATLANAPKERSRPVQEMIPLKFFAVDEVSCQINQEGAPKDVVEKVLFVLNNVTLANLNNKVDELKKSLTPNYFSWFSTYLVTQRAKTEPNYHDLYSKVIVAMGSGLLHQFMVNVTLRQLFVLLSTKDEQAIDKKHLKNLASWLGCITLALNKPIKHKNIAFREMLIEAYKENRLEIVVPFVTKILQRASESKIFKPPNPWTVGILKLLIELNEKANWKLSLTFEVEVLLKSFNLTTKSLKPSNFINTPEVIETLSGALGSITLEQQQTEQQRQIILMQQHQQQMLIYQQRQQQQQQRQQQQQHHISANTIADQQAAFGGEGSISHDNPFNNLLGSTIFVTHPDLKRVFQMALAKSVREILLEVVEKSSGIAVVTTTKIILKDFATEVDESKLKTAAIIMVRHLAQSLARATSIEPLKEGIRSTMQSLAPNLMSLSSSPAEELDTAINENIGIALVLIEKASMDKSTQDLADQLMQAIAIRRYHKERRADQPFITQNTNPYSLSLPEPLGLKNTGVTPQQFRVYEEFGKNIPNLDVIPFAGLPAHAPPMTQNVGLTQPQQQQAQMPTQILTSEQIRAQQQQQQLQKSRLNQPSQSAQPPGVNVPNPQGGIAAVQSDLEQNQRVLVHLMDILVSQIKENATKNNLAELGDQNQIKTIIFQILTFIAKSAQKDQLALKVSQAVVNSLFATSESPLCREVLSLLLEKLCSLSLVARKDVVWWLVYALDSRKFNVPVIRSLLEVNLIDATELDNVLVTAMKNKMENSTEFAMKLIQNTVLSDDPILMRMDFIKTLEHLASSEDENVKKFIKEFEDTKIMPVRKGTKTTRTEKLYLVFTEWVKLLQRVENNDVITTVFIKQLVEKGVISDTDNLLTFVKSSLELSVSSFKESDPTDEVFIAIDALGSLIIKLLILQGFKDDTRRDYINAIFSVIVLVFAKDHSQEGTTFNERPYFRLFSNILYEWATIRTHNFVRISDSSTRQELIEFDSVFYNTFSGYLHALQPFAFPGFSFAWVTLLSHRMLLPIMLRLPNKIGWEKLMLLIIDLFKFLDQYTSKHAVSDAVSVVYKGTLRVILGISNDMPSFLIENHYELMNNLPPTYFQLKNVILSAIPKNMTVPNPYDVDLNMEDIPACKELPEVFFDPVIDLHSLKKPVDNYLRIPSNSLLRTILSAIYKDTYDIKKGVGYDFLSVDSKLIRAIVLHVGIEAGIEYKRTSSNAVFNTKSSYYTLLFNLIQNGSIEMKYQIILSIVEQLRYPNIHTYWFSFVLMNMFKSDEWNDQKLEVQEIILRNFLKRIIVNKPHTWGVSVFFTQLINNNDINLLDLPFVQSVPEIKLILQQLVKYSKKYTTSEQDDQSATINRRQTPLQSNA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 139 | Ubiquitination | LFIDLFDKSANKDII HHHHHHCHHCCHHHH | 44.10 | 15699485 | |
| 143 | Ubiquitination | LFDKSANKDIIESLD HHCHHCCHHHHHHCC | 50.44 | 15699485 | |
| 339 | Phosphorylation | VSETIPNTKQSLLYL HHHCCCCHHHHHHHH | 25.71 | 25704821 | |
| 460 | Ubiquitination | APIANFLKSLLDTGR HHHHHHHHHHHHCCC | 34.61 | 17644757 | |
| 474 | Ubiquitination | RLDTVINKLPFNEAF CHHHHHHHCCCCHHH | 46.54 | 17644757 | |
| 482 | Ubiquitination | LPFNEAFKILPCARQ CCCCHHHHHHHHHHH | 50.83 | 17644757 | |
| 722 | Ubiquitination | AEYPQYCKDLLRDVP HHCHHHHHHHHHHCH | 46.61 | 23749301 | |
| 740 | Phosphorylation | SQAQVYQSIVEAATL HHHHHHHHHHHHHHH | 15.77 | 28889911 | |
| 752 | Ubiquitination | ATLANAPKERSRPVQ HHHCCCCCCCCCCHH | 64.45 | 23749301 | |
| 755 | Phosphorylation | ANAPKERSRPVQEMI CCCCCCCCCCHHHHC | 41.87 | 29136822 | |
| 773 | Phosphorylation | FFAVDEVSCQINQEG EEEECEEEEEECCCC | 9.77 | 27017623 | |
| 783 | Ubiquitination | INQEGAPKDVVEKVL ECCCCCCHHHHHHHH | 63.72 | 23749301 | |
| 811 | Phosphorylation | KVDELKKSLTPNYFS HHHHHHHHCCCCHHH | 35.57 | 28889911 | |
| 813 | Phosphorylation | DELKKSLTPNYFSWF HHHHHHCCCCHHHHH | 19.31 | 30377154 | |
| 816 | Phosphorylation | KKSLTPNYFSWFSTY HHHCCCCHHHHHHHH | 10.53 | 28889911 | |
| 818 | Phosphorylation | SLTPNYFSWFSTYLV HCCCCHHHHHHHHHH | 19.49 | 28889911 | |
| 821 | Phosphorylation | PNYFSWFSTYLVTQR CCHHHHHHHHHHHCC | 15.19 | 28889911 | |
| 822 | Phosphorylation | NYFSWFSTYLVTQRA CHHHHHHHHHHHCCC | 16.05 | 30377154 | |
| 823 | Phosphorylation | YFSWFSTYLVTQRAK HHHHHHHHHHHCCCC | 9.66 | 30377154 | |
| 826 | Phosphorylation | WFSTYLVTQRAKTEP HHHHHHHHCCCCCCC | 15.11 | 30377154 | |
| 835 | Phosphorylation | RAKTEPNYHDLYSKV CCCCCCCHHHHHHHH | 13.87 | 19779198 | |
| 981 | Ubiquitination | KSFNLTTKSLKPSNF HHCCCCCCCCCHHHC | 48.86 | 17644757 | |
| 984 | Ubiquitination | NLTTKSLKPSNFINT CCCCCCCCHHHCCCC | 54.19 | 17644757 | |
| 1255 | Ubiquitination | LPEPLGLKNTGVTPQ CCCCCCCCCCCCCHH | 51.14 | 17644757 | |
| 1260 | Phosphorylation | GLKNTGVTPQQFRVY CCCCCCCCHHHHHHH | 19.41 | 20377248 | |
| 1329 | Ubiquitination | QQQQQLQKSRLNQPS HHHHHHHHHHCCCCC | 46.25 | 23749301 | |
| 1384 | Ubiquitination | QIKENATKNNLAELG HHHHHCCCCCHHHHC | 41.23 | 23749301 | |
| 1421 | Phosphorylation | DQLALKVSQAVVNSL CHHHHHHHHHHHHHH | 15.72 | 29688323 | |
| 1427 | Phosphorylation | VSQAVVNSLFATSES HHHHHHHHHHCCCCC | 17.16 | 29688323 | |
| 1431 | Phosphorylation | VVNSLFATSESPLCR HHHHHHCCCCCHHHH | 26.20 | 29688323 | |
| 1432 | Phosphorylation | VNSLFATSESPLCRE HHHHHCCCCCHHHHH | 32.42 | 29688323 | |
| 1434 | Phosphorylation | SLFATSESPLCREVL HHHCCCCCHHHHHHH | 23.96 | 29688323 | |
| 1489 | Phosphorylation | EVNLIDATELDNVLV HCCCCCHHHHHHHHH | 33.08 | 21440633 | |
| 1506 | Phosphorylation | MKNKMENSTEFAMKL HHHCCCCCHHHHHHH | 18.92 | 21440633 | |
| 1550 | Ubiquitination | ENVKKFIKEFEDTKI HHHHHHHHHHCCCCE | 60.53 | 23749301 | |
| 1550 | Acetylation | ENVKKFIKEFEDTKI HHHHHHHHHHCCCCE | 60.53 | 24489116 | |
| 1598 | Ubiquitination | VITTVFIKQLVEKGV CEEHHHHHHHHHCCC | 26.56 | 15699485 | |
| 1603 | Ubiquitination | FIKQLVEKGVISDTD HHHHHHHCCCCCCCC | 51.50 | 15699485 | |
| 1657 | Ubiquitination | LLILQGFKDDTRRDY HHHHCCCCCCCCHHH | 62.61 | 24961812 | |
| 1891 | Ubiquitination | IDLHSLKKPVDNYLR CCHHHCCCCCCCCCC | 56.41 | 23749301 | |
| 1896 | Phosphorylation | LKKPVDNYLRIPSNS CCCCCCCCCCCCCHH | 7.90 | 19823750 | |
| 1901 | Phosphorylation | DNYLRIPSNSLLRTI CCCCCCCCHHHHHHH | 36.36 | 19823750 | |
| 1903 | Phosphorylation | YLRIPSNSLLRTILS CCCCCCHHHHHHHHH | 32.87 | 19823750 | |
| 1907 | Phosphorylation | PSNSLLRTILSAIYK CCHHHHHHHHHHHHH | 26.66 | 19823750 | |
| 1910 | Phosphorylation | SLLRTILSAIYKDTY HHHHHHHHHHHHCCC | 14.58 | 19823750 | |
| 1913 | Phosphorylation | RTILSAIYKDTYDIK HHHHHHHHHCCCCCC | 11.52 | 19823750 | |
| 1916 | Phosphorylation | LSAIYKDTYDIKKGV HHHHHHCCCCCCCCC | 20.95 | 19823750 | |
| 1917 | Phosphorylation | SAIYKDTYDIKKGVG HHHHHCCCCCCCCCC | 26.29 | 19823750 | |
| 1921 | Ubiquitination | KDTYDIKKGVGYDFL HCCCCCCCCCCCCCC | 60.19 | 23749301 | |
| 1953 | Phosphorylation | AGIEYKRTSSNAVFN CCCCEEECCCCCEEE | 32.15 | 19779198 | |
| 1963 | Phosphorylation | NAVFNTKSSYYTLLF CCEEECCCHHHHHHH | 22.87 | 19779198 | |
| 1967 | Phosphorylation | NTKSSYYTLLFNLIQ ECCCHHHHHHHHHHH | 14.57 | 19779198 | |
| 2080 | Acetylation | LILQQLVKYSKKYTT HHHHHHHHHHHCCCC | 53.01 | 24489116 | |
| 2084 | Ubiquitination | QLVKYSKKYTTSEQD HHHHHHHCCCCCCCC | 41.72 | 23749301 | |
| 2087 | Phosphorylation | KYSKKYTTSEQDDQS HHHHCCCCCCCCHHH | 27.46 | 19823750 | |
| 2088 | Phosphorylation | YSKKYTTSEQDDQSA HHHCCCCCCCCHHHC | 26.01 | 19823750 | |
| 2094 | Phosphorylation | TSEQDDQSATINRRQ CCCCCHHHCEECCCC | 34.08 | 20377248 | |
| 2096 | Phosphorylation | EQDDQSATINRRQTP CCCHHHCEECCCCCC | 24.83 | 20377248 | |
| 2102 | Phosphorylation | ATINRRQTPLQSNA- CEECCCCCCCCCCC- | 24.93 | 22369663 | |
| 2106 | Phosphorylation | RRQTPLQSNA----- CCCCCCCCCC----- | 42.27 | 20377248 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOT1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOT1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOT1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1260 AND THR-2102, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2102, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2102, AND MASSSPECTROMETRY. | |
