CF130_YEAST - dbPTM
CF130_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CF130_YEAST
UniProt AC P53280
Protein Name Protein CAF130
Gene Name CAF130
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1122
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover..
Protein Sequence MTKKKAATNYAERQNLASEDSSGDSVHFKDFIPLQELLKDKNYVPSVENLEKILYNETMFNDQKICSNLLLEALIITLFTTISGKSALRLIQTSSLKERKSWAQSFENNSSSYASIVLSWKDNDILLLKFLRFLLANKTAPLQINRYNLPEYKLPLSFLIVSKITIPSILLNETYNLLKDYLYSITGRIESLISCSSTFDKPALVVRKILKDYNRMIECRNFYFWYSFNAENRVNLTFSDNISLLMENDEGNAGSGLDDSRFDHQKQPREAIMGRTINDQEQIYSFELNQDGTLEIPNVMEHSLLRHELLFKILNLTTVLTPLLELQFSTLCGLVDPLMQPTPNDKHIISIDFLFQLFLGLMSQSIKTSQEHNDHYDWKFYMCFNMQKIIDATMLRLNCFDFDILNSVNNTDNAVHWKTQLHRWLPHGLNTQDLELLYMIDILAVYTIYKLYEKIPIQLNPFLFSLISLWKNLSCVILLALEIDRIEEENGTYETPLMVRATIRGAAALRSVIATVLNGLVKNNDHDFKHESLNTFMSPYGRKLCHGALYADLRSHTASLLALGASIEDVTDLFADLQSGDRFDEDIRYMFDYECEDYDESFSESDHGGLDESVVNPTEKIASGSNNVFFRRRCNCIFNDDKLVAEDGANEAFGSTNSENVEGAMHNNRNAVHNATTATSDHVVTSPNPLSVRSRSTFEFDYSGEDWRDVPRDFNMYYSPSYSFIHEPKLDVIFSLTLRGATEKLNKEESILLVRSVASCVRNEQDQMILADLESNFSASINGDVEGEGNTKMSKIDNEDLRRTTPDDIYEIWSEESAFERMLNVNHDVAWRLMDEMLMCTGYRRILIWFLTHLELKHSLIYYVFELIMGLRGKPFSGEASDQDKKDDMIYEILKKKQKNEDASGLPFSRQGPIVLSDIETKMLLQEFFMNAAIFLSSKNNEEENEDGEKISLYSLGLVRLICYMVQTLIANDKFFFTKSECTFELQTLLMTWIGILPEAKDLFFKIKTRLAMEEEDSADTMQHEGRKNSDIEKKLNAKPASELNLKLLNLFPSKPANKDDSSPINTLRSFIADYSFDTQVNPPGRRVVFYDGKILPLPKADKPIPLHEYITLAELDVGDSE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
111PhosphorylationQSFENNSSSYASIVL
HHHCCCCCCCEEEEE		29.5030377154
115PhosphorylationNNSSSYASIVLSWKD
CCCCCCEEEEEEECC		12.6621440633
119PhosphorylationSYASIVLSWKDNDIL
CCEEEEEEECCCHHH		22.6130377154
623PhosphorylationNPTEKIASGSNNVFF
CCCHHHCCCCCCCEE		46.3428889911
625PhosphorylationTEKIASGSNNVFFRR
CHHHCCCCCCCEEEE		23.8028889911
658PhosphorylationEAFGSTNSENVEGAM
CCCCCCCCCCCHHHC		30.5428889911
679PhosphorylationVHNATTATSDHVVTS
HCCCCCCCCCCEECC		32.3719779198
680PhosphorylationHNATTATSDHVVTSP
CCCCCCCCCCEECCC		24.2123749301
685PhosphorylationATSDHVVTSPNPLSV
CCCCCEECCCCCCCC		37.0623749301
686PhosphorylationTSDHVVTSPNPLSVR
CCCCEECCCCCCCCC		15.8625752575
691PhosphorylationVTSPNPLSVRSRSTF
ECCCCCCCCCCCCEE		19.4229688323
750PhosphorylationEKLNKEESILLVRSV
HHCCHHHHHHHHHHH		21.4527017623
756PhosphorylationESILLVRSVASCVRN
HHHHHHHHHHHHHHC		17.9827017623
852PhosphorylationRILIWFLTHLELKHS
HHHHHHHHHHHHHHH		18.2328889911
862PhosphorylationELKHSLIYYVFELIM
HHHHHHHHHHHHHHH		10.0028889911
863PhosphorylationLKHSLIYYVFELIMG
HHHHHHHHHHHHHHC		7.5328889911
917PhosphorylationRQGPIVLSDIETKML
CCCCEEECCHHHHHH		26.1627017623
921PhosphorylationIVLSDIETKMLLQEF
EEECCHHHHHHHHHH		23.3027017623
1030PhosphorylationQHEGRKNSDIEKKLN
CCCCCCCHHHHHHHC		42.8924961812
1042PhosphorylationKLNAKPASELNLKLL
HHCCCCHHHHCHHHH		51.6621551504
1063PhosphorylationPANKDDSSPINTLRS
CCCCCCCCHHHHHHH		36.4725752575
1121PhosphorylationAELDVGDSE------
EECCCCCCC------		39.0020377248
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CF130_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CF130_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CF130_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOT4_YEASTMOT2physical
11733989
NOT5_YEASTNOT5physical
11733989
CCR4_YEASTCCR4physical
16554755
NACB2_YEASTBTT1physical
16554755
NACA_YEASTEGD2physical
16554755
YJY1_YEASTYJR011Cphysical
16554755
YP216_YEASTYPL216Wphysical
16554755
PLC1_YEASTPLC1physical
16554755
SEM1_YEASTSEM1genetic
17314980
BMH1_YEASTBMH1genetic
17314980
SUS1_YEASTSUS1genetic
17314980
SAC3_YEASTSAC3genetic
17314980
TAF12_YEASTTAF12genetic
17314980
LSM6_YEASTLSM6genetic
17314980
NGG1_YEASTNGG1genetic
17314980
HOS2_YEASTHOS2genetic
17314980
PFD2_YEASTGIM4genetic
17314980
RPN10_YEASTRPN10genetic
17389396
PSA3_YEASTPRE9genetic
17389396
SEM1_YEASTSEM1genetic
17389396
NACB2_YEASTBTT1physical
18214544
CCR4_YEASTCCR4physical
18214544
SAC3_YEASTSAC3genetic
19061648
SEM1_YEASTSEM1genetic
19061648
CSK2C_YEASTCKB2genetic
19061648
AIR1_YEASTAIR1genetic
19061648
YRB2_YEASTYRB2genetic
19061648
TGS1_YEASTTGS1genetic
19061648
THP2_YEASTTHP2genetic
19061648
ARC1_YEASTARC1genetic
19061648
PFD4_YEASTGIM3genetic
19061648
KA120_YEASTKAP120genetic
19061648
NOT1_YEASTCDC39physical
19707589
CF130_YEASTCAF130physical
19707589
NOT5_YEASTNOT5physical
19707589
RRP41_YEASTSKI6physical
19707589
RRP42_YEASTRRP42physical
19707589
MLP1_YEASTMLP1physical
21464899
TCPZ_YEASTCCT6genetic
27708008
DYR_YEASTDFR1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
GID4_YEASTVID24genetic
27708008
IRC15_YEASTIRC15genetic
27708008
MET31_YEASTMET31genetic
27708008
WDR6_YEASTRTT10genetic
27708008
APC11_YEASTAPC11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
NOP14_YEASTNOP14genetic
27708008
SC61G_YEASTSSS1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
RPN11_YEASTRPN11genetic
27708008
PSB7_YEASTPRE4genetic
27708008
PRS8_YEASTRPT6genetic
27708008
NU145_YEASTNUP145genetic
27708008
RPN1_YEASTRPN1genetic
27708008
MED6_YEASTMED6genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
RNA1_YEASTRNA1genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
MED4_YEASTMED4genetic
27708008
PSA7_YEASTPRE10genetic
27708008
SEC62_YEASTSEC62genetic
27708008
ASA1_YEASTASA1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
RPN7_YEASTRPN7genetic
27708008
LTE1_YEASTLTE1genetic
27708008
FUN19_YEASTFUN19genetic
27708008
ECM15_YEASTECM15genetic
27708008
MUM2_YEASTMUM2genetic
27708008
PFF1_YEASTPFF1genetic
27708008
MTC4_YEASTMTC4genetic
27708008
CHK1_YEASTCHK1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
PRM7_YEASTPRM7genetic
27708008
LHP1_YEASTLHP1genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
DAS2_YEASTDAS2genetic
27708008
MNN10_YEASTMNN10genetic
27708008
UBX5_YEASTUBX5genetic
27708008
HXT3_YEASTHXT3genetic
27708008
SEM1_YEASTSEM1genetic
27708008
FLO8_YEASTFLO8genetic
27708008
SCS2_YEASTSCS2genetic
27708008
RAD4_YEASTRAD4genetic
27708008
CAF16_YEASTCAF16genetic
27708008
UBP6_YEASTUBP6genetic
27708008
SODM_YEASTSOD2genetic
27708008
PIH1_YEASTPIH1genetic
27708008
MED20_YEASTSRB2genetic
27708008
YIF4_YEASTYIL054Wgenetic
27708008
ICE2_YEASTICE2genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
SOP4_YEASTSOP4genetic
27708008
ANR2_YEASTANR2genetic
27708008
CAF4_YEASTCAF4genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
PHO84_YEASTPHO84genetic
27708008
SGS1_YEASTSGS1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
ADH2_YEASTADH2genetic
27708008
RNH2A_YEASTRNH201genetic
27708008
SKI7_YEASTSKI7genetic
27708008
VAM3_YEASTVAM3genetic
27708008
VPH1_YEASTVPH1genetic
27708008
UBP16_YEASTUBP16genetic
27708008
TGS1_YEASTTGS1genetic
27708008
YAR1_YEASTYAR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CF130_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623; SER-625; THR-685;SER-686; SER-1042 AND SER-1063, AND MASS SPECTROMETRY.

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