PFF1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PFF1_YEAST
• UniProt AC: P38244
• Protein Name: Vacuolar membrane protease {ECO:0000305|PubMed:23679341}
• Gene Name: PFF1 {ECO:0000303|PubMed:23679341}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 976
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein .
• Protein Description: May be involved in vacuolar sorting and osmoregulation..
• Protein Sequence: MKLKSVFRSVLKYRKTNLSLLLLITYSIITLLYIFDHERYKLNLPKEDEHPEFNDLLETAWGDLQIITASFHPYTSKENDKVHDYLLKRVLEITGNSSFASVSDDKESERSILFQQQDPFNESSRFSRVTYFESSNILVKLEGKNPEEEGLLLSAHFDSVPTGYGATDDGMGVVSLLANLKYHIKHRPNRTLIFNFNNNEEFGLLGASTYFDHSWSNLTKYVINLEGTGAGGKAVLFRTSDTSTARIYQQSVKENPFGNSIYQQGFYSRYVRSETDYKIYEENGMRGWDVAFYKPRNLYHTIKDSIQYTSKASLWHMLHTSLQLSAYVASNSLDTADQTPACYFDFIGLKFFVISAKTLFYWNCIFLLVSPVVAIGLYLISRDRMTWKSYSWLSWTRFPLSLAAGIIVQKLFSNDIIRSNPLTFSRNYFWPISAFFTQVIFTSYVLINCSNFFFPCADMKSLSIIELFIILWTILLFTSKLLYSSDYRYTGLYPLSIFFLLSTIAAILRLLALALGMRTRKRLGRECRDHHSNYSSHSQIDMERDGQENLEQPQDQLTSSQDDQASIQDDNVSTTSAGPSHNVDEDHGMDSSSQQHDERVPLLKGSNSMEEGLSTRENSLKLEYTDYAWIIQFLLIVPIPSFILFNSVDVIMDALNHTVQEGSKATFDVLRFGMVGSILIALPILPFFYKVNYITISLTALLFLISASKTLLVHPFTNSNPLKVRFSQNIDLSQGNAASVHVLGREGNFLKPMLQDLPSIKYSSTHINCTSVTNGMELCMYDGMQPNLLSTNGNTNISSMVKVHVLHNNRNSTERSPYEPIVAELLLEVKENRACTLTFESRHQAKSPVREITVYQKKNSAPQKANITKTIKSASGINELQLHKLDFDQETYHIGVQWFPKLLTDGNVEDDKLGTKDELSVSISCYWGEYDSESVVNGTAVRKIPAFDELINYAPLSFSFTNEQKGLVIVKDAIIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKLKSVFRSVLK ---CCHHHHHHHHHH		28889911
94	Phosphorylation	LKRVLEITGNSSFAS HHHHHHHHCCCCCCC		28889911
96	N-linked_Glycosylation	RVLEITGNSSFASVS HHHHHHCCCCCCCCC		-
97	Phosphorylation	VLEITGNSSFASVSD HHHHHCCCCCCCCCC		28889911
98	Phosphorylation	LEITGNSSFASVSDD HHHHCCCCCCCCCCC		28889911
103	Phosphorylation	NSSFASVSDDKESER CCCCCCCCCCCHHHH		28889911
108	Phosphorylation	SVSDDKESERSILFQ CCCCCCHHHHHHHHC		28889911
121	N-linked_Glycosylation	FQQQDPFNESSRFSR HCCCCCCCCCCCCEE		-
189	N-linked_Glycosylation	YHIKHRPNRTLIFNF HHHHCCCCCEEEEEC		-
217	N-linked_Glycosylation	YFDHSWSNLTKYVIN ECCCCHHHCCEEEEE		-
253	Ubiquitination	RIYQQSVKENPFGNS HHHHHHHHHCCCCCC		23749301
303	Acetylation	RNLYHTIKDSIQYTS CCHHHHHHHHHHHCC		24489116
532	Phosphorylation	RECRDHHSNYSSHSQ HHHHHCCCCCCCCCC		25704821
534	Phosphorylation	CRDHHSNYSSHSQID HHHCCCCCCCCCCCC		19779198
535	Phosphorylation	RDHHSNYSSHSQIDM HHCCCCCCCCCCCCC		17330950
536	Phosphorylation	DHHSNYSSHSQIDME HCCCCCCCCCCCCCC		28889911
538	Phosphorylation	HSNYSSHSQIDMERD CCCCCCCCCCCCCCC		28889911
604	Ubiquitination	DERVPLLKGSNSMEE HHCCCCCCCCCCHHC		23749301
606	Phosphorylation	RVPLLKGSNSMEEGL CCCCCCCCCCHHCCC		22369663
608	Phosphorylation	PLLKGSNSMEEGLST CCCCCCCCHHCCCCC		22369663
614	Phosphorylation	NSMEEGLSTRENSLK CCHHCCCCCHHCCCC		22890988
615	Phosphorylation	SMEEGLSTRENSLKL CHHCCCCCHHCCCCC		22890988
619	Phosphorylation	GLSTRENSLKLEYTD CCCCHHCCCCCEECC		19823750
656	N-linked_Glycosylation	DVIMDALNHTVQEGS HHHHHHHHCHHHHCC		-
768	N-linked_Glycosylation	KYSSTHINCTSVTNG CCCCCCCCCEECCCC		-
790	Phosphorylation	GMQPNLLSTNGNTNI CCCCCCEECCCCCCH		27017623
796	N-linked_Glycosylation	LSTNGNTNISSMVKV EECCCCCCHHHCEEE		-
811	N-linked_Glycosylation	HVLHNNRNSTERSPY EEEECCCCCCCCCCC		-
866	N-linked_Glycosylation	NSAPQKANITKTIKS CCCCCCCCHHHHHHH		-
937	N-linked_Glycosylation	YDSESVVNGTAVRKI CCCCCEECCEEEEEC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PFF1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PFF1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PFF1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SC61A_YEAST	SEC61	physical	23679341

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.