PLC1_YEAST - dbPTM
PLC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLC1_YEAST
UniProt AC P32383
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
Gene Name PLC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 869
Subcellular Localization
Protein Description The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1..
Protein Sequence MTESAIDDQRFNLTKELQRHSCRDQGKITQKDDALDFISYSSFQSSFNTDQKSANNGSTVRRSIRSIFRRAAELPRVHMGPLTYSHGINELVNKKLRKDCDLSTLCRVLQRGIRMIRMTRRRRKFYEFKLINNNGQIIWKDGSKYLELDSVKDIRIGDTASTYQEEVDPKRLRSDSKLWIAIIYKVSNKLKALHVVALNELDFNTFLSCICGLVKLRRELMESILLPDNSQFARIHWQITVSEKEEDEKKDTLSFADVKKLCDKFHIYVSTGQLLEFFQLADINHNGLLNYFEFEKFIKILKNRKEVNMIWSKFTKPPHSHLSFENFFQFLITEQHEQVDRQTAWSYFIKYREPTQLTMGQDGFTKFLKEQPYLVEVKEELYSKPLNHYFIASSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENGPVVCHGFLTSAIPLKTVIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMREVLAEQLYFVGTRTDKLPSPRELKHKILLKSKKTSEATRGLSVNEPFPSSFSSSYESANEQELRMKDDSTNSSSATNSSSMQRIKRIGLKKHADIINDVSNISGIHGIKFRNFSLPESKTIAHCFSLNERKVEYMIKDKHLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQLNLAMFQILDHQPDGSFKSGYVLKPKKLLPVVTKAKMIPLIYEHFENGSDPVTVKIRILSTQLLPRLNDTSPSRNNTNSFVKVEFHTDDEPTMPISIDKGTRISATEASTKSSQGNGFNPIWDAEVSITLKDTDLTFIKFMVISEETQIASVCLKLNYLRMGYRHIPLFNMEGEQYIFCTLFIHTQIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
150PhosphorylationSKYLELDSVKDIRIG
CEEEEECCCEEEEEC		43.6319779198
530PhosphorylationSEATRGLSVNEPFPS
CCCCCCCCCCCCCCC		26.2229688323
537PhosphorylationSVNEPFPSSFSSSYE
CCCCCCCCCCCCCCC		44.3829688323
538PhosphorylationVNEPFPSSFSSSYES
CCCCCCCCCCCCCCC		29.4129688323
540PhosphorylationEPFPSSFSSSYESAN
CCCCCCCCCCCCCCC		21.9629688323
541PhosphorylationPFPSSFSSSYESANE
CCCCCCCCCCCCCCH		34.6229688323
542PhosphorylationFPSSFSSSYESANEQ
CCCCCCCCCCCCCHH		31.5529688323
543PhosphorylationPSSFSSSYESANEQE
CCCCCCCCCCCCHHH		18.8229688323
545PhosphorylationSFSSSYESANEQELR
CCCCCCCCCCHHHHH		28.3229688323
554UbiquitinationNEQELRMKDDSTNSS
CHHHHHCCCCCCCCC		52.5323749301
557PhosphorylationELRMKDDSTNSSSAT
HHHCCCCCCCCCCCC		39.3527017623
566PhosphorylationNSSSATNSSSMQRIK
CCCCCCCHHHHHHHH		21.3119779198
567PhosphorylationSSSATNSSSMQRIKR
CCCCCCHHHHHHHHH		31.7227017623
579UbiquitinationIKRIGLKKHADIIND
HHHHCCHHHHHHHHC		49.4117644757
597UbiquitinationISGIHGIKFRNFSLP
CCCCCCCEECCCCCC		42.7517644757
652UbiquitinationYPHVLRYKSSNFNPI
HHHHHHHCCCCCCCC		40.7617644757
663UbiquitinationFNPIPFWKAGVQMVA
CCCCCHHHHHEEEEE		35.3217644757
699UbiquitinationHQPDGSFKSGYVLKP
CCCCCCCCCCEECCH		44.6717644757
705UbiquitinationFKSGYVLKPKKLLPV
CCCCEECCHHHHCCC		44.7617644757
707UbiquitinationSGYVLKPKKLLPVVT
CCEECCHHHHCCCCC		55.2417644757
708UbiquitinationGYVLKPKKLLPVVTK
CEECCHHHHCCCCCH		64.8817644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SGD1_YEASTSGD1physical
12073033
GPR1_YEASTGPR1physical
10514491
CBF3A_YEASTCBF2physical
10779349
CBF3B_YEASTCEP3physical
10779349
TOR2_YEASTTOR2physical
9826521
PHO81_YEASTPHO81genetic
9475719
SGD1_YEASTSGD1genetic
12073033
SPL2_YEASTSPL2genetic
9475719
STE11_YEASTSTE11genetic
10514491
KAPB_YEASTTPK2genetic
10514491
SKP1_YEASTSKP1genetic
12756538
MIF2_YEASTMIF2genetic
12756538
CBF3A_YEASTCBF2genetic
10779349
IPK1_YEASTIPK1genetic
14618376
IPMK_YEASTARG82genetic
14618376
FKS1_YEASTFKS1genetic
16352614
MED2_YEASTMED2genetic
16352614
MED16_YEASTSIN4genetic
16352614
MED1_YEASTMED1genetic
16352614
SRB8_YEASTSRB8genetic
16352614
SSN3_YEASTSSN3genetic
16352614
SSN8_YEASTSSN8genetic
16352614
VAC14_YEASTVAC14physical
18719252
ATG17_YEASTATG17physical
18719252
CYC8_YEASTCYC8genetic
19269370
F26_YEASTFBP26genetic
19269370
RFA2_YEASTRFA2genetic
19269370
SFH1_YEASTSFH1genetic
19205744
STH1_YEASTSTH1genetic
19205744
RSC2_YEASTRSC2genetic
19205744
BUB1_YEASTBUB1genetic
12756538
BUB2_YEASTBUB2genetic
12756538
BUB3_YEASTBUB3genetic
12756538
CBF3A_YEASTCBF2genetic
12756538
CBF3B_YEASTCEP3genetic
12756538
HOG1_YEASTHOG1genetic
12073033
RS3A2_YEASTRPS1Bgenetic
17461973
SSN8_YEASTSSN8genetic
10207058
ARGJ_YEASTARG7genetic
21623372
ADH1_YEASTADH1genetic
21623372
PUT2_YEASTPUT2genetic
21623372
GLPK_YEASTGUT1genetic
21623372
INP53_YEASTINP53genetic
21623372
JLP1_YEASTJLP1genetic
21623372
TKT1_YEASTTKL1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
SDHX_YEASTYJL045Wgenetic
21623372
MED16_YEASTSIN4genetic
22137896
HDA1_YEASTHDA1genetic
23913687
GCN5_YEASTGCN5genetic
23913687
SPT7_YEASTSPT7genetic
23913687
SPT3_YEASTSPT3genetic
23913687
SPT20_YEASTSPT20genetic
23913687
YNG2_YEASTYNG2genetic
23913687
EAF1_YEASTEAF1genetic
23913687
ACAC_YEASTACC1genetic
23913687
MTH1_YEASTMTH1genetic
23913687
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLC1_YEAST

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Related Literatures of Post-Translational Modification

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