IPMK_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPMK_YEAST
• UniProt AC: P07250
• Protein Name: Inositol polyphosphate multikinase
• Gene Name: ARG82
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 355
• Subcellular Localization: Nucleus .
• Protein Description: Has kinase activity and phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. With ARG80, ARG81 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine. Recruits ARG80 and MCM21 to stabilize them..
• Protein Sequence: MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDAPLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENLLYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDDDAEGSSEGPKDKKTTGSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIFMKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDTVNNYR -------CCCCCCEE	9.82	22814378
54	Phosphorylation	RDVSRRKSSADGDAP CCCCCCCCCCCCCCC	29.01	19779198
55	Phosphorylation	DVSRRKSSADGDAPL CCCCCCCCCCCCCCH	33.15	21440633
95	Phosphorylation	LKIDERLSDSTDNLD EEHHHHHCCCCCCCC	35.42	22369663
97	Phosphorylation	IDERLSDSTDNLDSI HHHHHCCCCCCCCCC	33.99	22369663
98	Phosphorylation	DERLSDSTDNLDSIP HHHHCCCCCCCCCCC	33.62	22369663
103	Phosphorylation	DSTDNLDSIPVKSEK CCCCCCCCCCCCCHH	31.77	22369663
108	Phosphorylation	LDSIPVKSEKSKQYL CCCCCCCCHHHHHEE	50.95	29136822
177	Phosphorylation	MKIQKNPSVLNQLSL EEECCCHHHHHHHHH	48.94	28889911
305	Phosphorylation	DDDDAEGSSEGPKDK CCCCCCCCCCCCCCC	19.40	21440633
306	Phosphorylation	DDDAEGSSEGPKDKK CCCCCCCCCCCCCCC	58.38	19779198
314	Phosphorylation	EGPKDKKTTGSLSSM CCCCCCCCCCCCCHH	41.97	21126336
315	Phosphorylation	GPKDKKTTGSLSSMS CCCCCCCCCCCCHHC	33.38	21126336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPMK_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPMK_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPMK_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARGR1_YEAST	ARG80	physical	12828642
MCM1_YEAST	MCM1	physical	12828642
ARGR1_YEAST	ARG80	physical	10632874
MCM1_YEAST	MCM1	physical	10632874
MCM1_YEAST	MCM1	genetic	8043104
IPK1_YEAST	IPK1	genetic	15944147
ARGR1_YEAST	ARG80	physical	18719252
MCM1_YEAST	MCM1	physical	18719252
PP2C1_YEAST	PTC1	genetic	21127252
HIR1_YEAST	HIR1	genetic	21127252
KCS1_YEAST	KCS1	genetic	21127252
DUN1_YEAST	DUN1	genetic	21127252
RTG3_YEAST	RTG3	genetic	21127252
PLC1_YEAST	PLC1	genetic	22153127
YVC1_YEAST	YVC1	genetic	22153127
IPMK_YEAST	ARG82	physical	22940862

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95; SER-97; THR-98 ANDSER-177, AND MASS SPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, AND MASSSPECTROMETRY.
PubMed: 17563356