| UniProt ID | ACAC_YEAST | |
|---|---|---|
| UniProt AC | Q00955 | |
| Protein Name | Acetyl-CoA carboxylase | |
| Gene Name | ACC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 2233 | |
| Subcellular Localization |
Cytoplasm. Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side. |
|
| Protein Description | Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.. | |
| Protein Sequence | MSEESLFESSPQKMEYEITNYSERHTELPGHFIGLNTVDKLEESPLRDFVKSHGGHTVISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANAEYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSKRKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIYQKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVEREEDFIALYHQAANEIPGSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIAKAETFHEMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKGHCTACRITSEDPNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGHIFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETEDFEDNTITTGWLDDLITHKMTAEKPDPTLAVICGAATKAFLASEEARHKYIESLQKGQVLSKDLLQTMFPVDFIHEGKRYKFTVAKSGNDRYTLFINGSKCDIILRQLSDGGLLIAIGGKSHTIYWKEEVAATRLSVDSMTTLLEVENDPTQLRTPSPGKLVKFLVENGEHIIKGQPYAEIEVMKMQMPLVSQENGIVQLLKQPGSTIVAGDIMAIMTLDDPSKVKHALPFEGMLPDFGSPVIEGTKPAYKFKSLVSTLENILKGYDNQVIMNASLQQLIEVLRNPKLPYSEWKLHISALHSRLPAKLDEQMEELVARSLRRGAVFPARQLSKLIDMAVKNPEYNPDKLLGAVVEPLADIAHKYSNGLEAHEHSIFVHFLEEYYEVEKLFNGPNVREENIILKLRDENPKDLDKVALTVLSHSKVSAKNNLILAILKHYQPLCKLSSKVSAIFSTPLQHIVELESKATAKVALQAREILIQGALPSVKERTEQIEHILKSSVVKVAYGSSNPKRSEPDLNILKDLIDSNYVVFDVLLQFLTHQDPVVTAAAAQVYIRRAYRAYTIGDIRVHEGVTVPIVEWKFQLPSAAFSTFPTVKSKMGMNRAVSVSDLSYVANSQSSPLREGILMAVDHLDDVDEILSQSLEVIPRHQSSSNGPAPDRSGSSASLSNVANVCVASTEGFESEEEILVRLREILDLNKQELINASIRRITFMFGFKDGSYPKYYTFNGPNYNENETIRHIEPALAFQLELGRLSNFNIKPIFTDNRNIHVYEAVSKTSPLDKRFFTRGIIRTGHIRDDISIQEYLTSEANRLMSDILDNLEVTDTSNSDLNHIFINFIAVFDISPEDVEAAFGGFLERFGKRLLRLRVSSAEIRIIIKDPQTGAPVPLRALINNVSGYVIKTEMYTEVKNAKGEWVFKSLGKPGSMHLRPIATPYPVKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNELIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFKIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVRLGQRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQIMYNNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETYDVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQEPGQVWHPNSAFKTAQAINDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPQGMVGIKFRREKLLDTMNRLDDKYRELRSQLSNKSLAPEVHQQISKQLADRERELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHQVGEASRLEKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGLKLESFAQDLAKKIRSDHDNAIDGLSEVIKMLSTDDKEKLLKTLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEESLFES ------CCHHHHHCC | 62.47 | 22814378 | |
| 2 | Phosphorylation | ------MSEESLFES ------CCHHHHHCC | 62.47 | 22369663 | |
| 5 | Phosphorylation | ---MSEESLFESSPQ ---CCHHHHHCCCCC | 34.02 | 22369663 | |
| 9 | Phosphorylation | SEESLFESSPQKMEY CHHHHHCCCCCCCEE | 39.73 | 22369663 | |
| 10 | Phosphorylation | EESLFESSPQKMEYE HHHHHCCCCCCCEEE | 24.93 | 22369663 | |
| 16 | Phosphorylation | SSPQKMEYEITNYSE CCCCCCEEEECCHHH | 14.77 | 22369663 | |
| 22 | Phosphorylation | EYEITNYSERHTELP EEEECCHHHHCCCCC | 30.17 | 28889911 | |
| 40 | Acetylation | IGLNTVDKLEESPLR CCCCCCCCCCCCCHH | 54.16 | 24489116 | |
| 40 | Ubiquitination | IGLNTVDKLEESPLR CCCCCCCCCCCCCHH | 54.16 | 17644757 | |
| 51 | Acetylation | SPLRDFVKSHGGHTV CCHHHHHHHCCCCEE | 36.41 | 22865919 | |
| 51 | Ubiquitination | SPLRDFVKSHGGHTV CCHHHHHHHCCCCEE | 36.41 | 17644757 | |
| 52 | Phosphorylation | PLRDFVKSHGGHTVI CHHHHHHHCCCCEEE | 23.28 | 27017623 | |
| 57 | Phosphorylation | VKSHGGHTVISKILI HHHCCCCEEEEEEEE | 23.86 | 27017623 | |
| 61 | Ubiquitination | GGHTVISKILIANNG CCCEEEEEEEEECCC | 30.33 | 17644757 | |
| 73 | Acetylation | NNGIAAVKEIRSVRK CCCCHHHHHHHHHHH | 42.57 | 24489116 | |
| 73 | Ubiquitination | NNGIAAVKEIRSVRK CCCCHHHHHHHHHHH | 42.57 | 23749301 | |
| 80 | Acetylation | KEIRSVRKWAYETFG HHHHHHHHHHHHHHC | 33.74 | 24489116 | |
| 162 | Ubiquitination | ENPLLPEKLSQSKRK CCCCCCHHHCCCCCE | 52.04 | 17644757 | |
| 186 | Ubiquitination | AMRSLGDKISSTIVA HHHHCHHHHHHCHHC | 42.56 | 23749301 | |
| 197 | Ubiquitination | TIVAQSAKVPCIPWS CHHCCCCCCCEECCC | 52.54 | 23749301 | |
| 216 | Ubiquitination | DTVHVDEKTGLVSVD CEEEEECCCCEEEEC | 43.35 | 23749301 | |
| 229 | Ubiquitination | VDDDIYQKGCCTSPE ECCCHHCCCCCCCCC | 36.62 | 23749301 | |
| 233 | Phosphorylation | IYQKGCCTSPEDGLQ HHCCCCCCCCCHHHH | 51.93 | 27214570 | |
| 234 | Phosphorylation | YQKGCCTSPEDGLQK HCCCCCCCCCHHHHH | 16.63 | 23749301 | |
| 241 | Ubiquitination | SPEDGLQKAKRIGFP CCCHHHHHHHHHCCC | 62.00 | 23749301 | |
| 252 | Ubiquitination | IGFPVMIKASEGGGG HCCCEEEEECCCCCC | 27.97 | 23749301 | |
| 327 | Acetylation | SVQRRHQKIIEEAPV CHHHHHHHHHHHCCE | 39.25 | 24489116 | |
| 327 | Ubiquitination | SVQRRHQKIIEEAPV CHHHHHHHHHHHCCE | 39.25 | 23749301 | |
| 338 | Acetylation | EAPVTIAKAETFHEM HCCEEEEECCCHHHH | 42.79 | 24489116 | |
| 338 | Ubiquitination | EAPVTIAKAETFHEM HCCEEEEECCCHHHH | 42.79 | 17644757 | |
| 341 | Phosphorylation | VTIAKAETFHEMEKA EEEEECCCHHHHHHH | 34.84 | 23749301 | |
| 347 | Acetylation | ETFHEMEKAAVRLGK CCHHHHHHHHHHHHH | 40.09 | 24489116 | |
| 347 | Ubiquitination | ETFHEMEKAAVRLGK CCHHHHHHHHHHHHH | 40.09 | 17644757 | |
| 354 | Ubiquitination | KAAVRLGKLVGYVSA HHHHHHHHHHEEEEE | 44.59 | 17644757 | |
| 358 | Phosphorylation | RLGKLVGYVSAGTVE HHHHHHEEEEEEEEE | 5.46 | 27017623 | |
| 360 | Phosphorylation | GKLVGYVSAGTVEYL HHHHEEEEEEEEEEE | 16.70 | 27017623 | |
| 366 | Phosphorylation | VSAGTVEYLYSHDDG EEEEEEEEEEECCCC | 13.45 | 27017623 | |
| 368 | Phosphorylation | AGTVEYLYSHDDGKF EEEEEEEEECCCCEE | 11.76 | 27017623 | |
| 369 | Phosphorylation | GTVEYLYSHDDGKFY EEEEEEEECCCCEEE | 20.18 | 27017623 | |
| 374 | Ubiquitination | LYSHDDGKFYFLELN EEECCCCEEEEEEEC | 43.83 | 17644757 | |
| 430 | Phosphorylation | GMNPHSASEIDFEFK CCCCCCCCCCCEEEE | 37.79 | 28889911 | |
| 437 | Acetylation | SEIDFEFKTQDATKK CCCCEEEECCCCCCC | 37.77 | 24489116 | |
| 437 | Ubiquitination | SEIDFEFKTQDATKK CCCCEEEECCCCCCC | 37.77 | 17644757 | |
| 469 | Acetylation | EDPNDGFKPSGGTLH CCCCCCCCCCCCEEE | 43.75 | 24489116 | |
| 469 | Ubiquitination | EDPNDGFKPSGGTLH CCCCCCCCCCCCEEE | 43.75 | 23749301 | |
| 545 | Ubiquitination | TTVEYLIKLLETEDF HHHHHHHHHHHCCCC | 44.41 | 17644757 | |
| 569 | Ubiquitination | LDDLITHKMTAEKPD HHHHHHHCCCCCCCC | 29.33 | 17644757 | |
| 571 | Phosphorylation | DLITHKMTAEKPDPT HHHHHCCCCCCCCCC | 36.15 | 28889911 | |
| 574 | Acetylation | THKMTAEKPDPTLAV HHCCCCCCCCCCCHH | 52.86 | 24489116 | |
| 574 | Ubiquitination | THKMTAEKPDPTLAV HHCCCCCCCCCCCHH | 52.86 | 23749301 | |
| 588 | Ubiquitination | VICGAATKAFLASEE HHCCHHHHHHHCCHH | 32.20 | 17644757 | |
| 599 | Acetylation | ASEEARHKYIESLQK CCHHHHHHHHHHHHH | 42.23 | 24489116 | |
| 606 | Ubiquitination | KYIESLQKGQVLSKD HHHHHHHHCCCCCHH | 57.51 | 23749301 | |
| 612 | Acetylation | QKGQVLSKDLLQTMF HHCCCCCHHHHHHHC | 48.51 | 24489116 | |
| 628 | Acetylation | VDFIHEGKRYKFTVA CCEEECCEEEEEEEE | 49.96 | 24489116 | |
| 670 | Ubiquitination | LLIAIGGKSHTIYWK EEEEECCCCCEEEEC | 33.57 | 17644757 | |
| 677 | Ubiquitination | KSHTIYWKEEVAATR CCCEEEECHHHHCCE | 27.33 | 17644757 | |
| 713 | Acetylation | PSPGKLVKFLVENGE CCCCCEEEEEEECCC | 43.34 | 24489116 | |
| 713 | Ubiquitination | PSPGKLVKFLVENGE CCCCCEEEEEEECCC | 43.34 | 17644757 | |
| 724 | Ubiquitination | ENGEHIIKGQPYAEI ECCCEEECCCCCEEE | 51.38 | 17644757 | |
| 735 | N6-biotinyllysine | YAEIEVMKMQMPLVS CEEEEEEECCCCEEE | 31.02 | - | |
| 735 | Biotinylation | YAEIEVMKMQMPLVS CEEEEEEECCCCEEE | 31.02 | - | |
| 776 | Ubiquitination | LDDPSKVKHALPFEG CCCHHHCCCCCCCCC | 27.22 | 17644757 | |
| 790 | Phosphorylation | GMLPDFGSPVIEGTK CCCCCCCCCCCCCCC | 18.91 | 28889911 | |
| 796 | Phosphorylation | GSPVIEGTKPAYKFK CCCCCCCCCCHHHHH | 22.51 | 19779198 | |
| 797 | Acetylation | SPVIEGTKPAYKFKS CCCCCCCCCHHHHHH | 38.21 | 24489116 | |
| 797 | Ubiquitination | SPVIEGTKPAYKFKS CCCCCCCCCHHHHHH | 38.21 | 17644757 | |
| 801 | Acetylation | EGTKPAYKFKSLVST CCCCCHHHHHHHHHH | 48.71 | 24489116 | |
| 801 | Ubiquitination | EGTKPAYKFKSLVST CCCCCHHHHHHHHHH | 48.71 | 17644757 | |
| 803 | Acetylation | TKPAYKFKSLVSTLE CCCHHHHHHHHHHHH | 38.43 | 24489116 | |
| 804 | Phosphorylation | KPAYKFKSLVSTLEN CCHHHHHHHHHHHHH | 36.82 | 21440633 | |
| 837 | Acetylation | IEVLRNPKLPYSEWK HHHHHCCCCCHHHHH | 66.69 | 24489116 | |
| 837 | Ubiquitination | IEVLRNPKLPYSEWK HHHHHCCCCCHHHHH | 66.69 | 23749301 | |
| 844 | Acetylation | KLPYSEWKLHISALH CCCHHHHHHHHHHHH | 26.57 | 24489116 | |
| 844 | Ubiquitination | KLPYSEWKLHISALH CCCHHHHHHHHHHHH | 26.57 | 17644757 | |
| 857 | Acetylation | LHSRLPAKLDEQMEE HHHCCCHHHHHHHHH | 55.31 | 24489116 | |
| 857 | Ubiquitination | LHSRLPAKLDEQMEE HHHCCCHHHHHHHHH | 55.31 | 17644757 | |
| 883 | Acetylation | FPARQLSKLIDMAVK CCHHHHHHHHHHHHH | 59.04 | 24489116 | |
| 890 | Acetylation | KLIDMAVKNPEYNPD HHHHHHHHCCCCCHH | 58.19 | 24489116 | |
| 890 | Ubiquitination | KLIDMAVKNPEYNPD HHHHHHHHCCCCCHH | 58.19 | 23749301 | |
| 898 | Acetylation | NPEYNPDKLLGAVVE CCCCCHHHHHHHHHH | 47.04 | 24489116 | |
| 898 | Ubiquitination | NPEYNPDKLLGAVVE CCCCCHHHHHHHHHH | 47.04 | 23749301 | |
| 913 | Ubiquitination | PLADIAHKYSNGLEA HHHHHHHHHCCCHHH | 41.16 | 17644757 | |
| 953 | Acetylation | REENIILKLRDENPK CCCEEEEEECCCCCC | 30.94 | 24489116 | |
| 953 | Ubiquitination | REENIILKLRDENPK CCCEEEEEECCCCCC | 30.94 | 24961812 | |
| 960 | Ubiquitination | KLRDENPKDLDKVAL EECCCCCCCCCHHHH | 80.60 | 15699485 | |
| 964 | Acetylation | ENPKDLDKVALTVLS CCCCCCCHHHHHHHH | 36.38 | 24489116 | |
| 964 | Ubiquitination | ENPKDLDKVALTVLS CCCCCCCHHHHHHHH | 36.38 | 17644757 | |
| 968 | Phosphorylation | DLDKVALTVLSHSKV CCCHHHHHHHHCCCC | 15.06 | 19823750 | |
| 971 | Phosphorylation | KVALTVLSHSKVSAK HHHHHHHHCCCCCCC | 22.75 | 19823750 | |
| 973 | Phosphorylation | ALTVLSHSKVSAKNN HHHHHHCCCCCCCCC | 31.23 | 19823750 | |
| 974 | Ubiquitination | LTVLSHSKVSAKNNL HHHHHCCCCCCCCCH | 34.48 | 17644757 | |
| 976 | Phosphorylation | VLSHSKVSAKNNLIL HHHCCCCCCCCCHHH | 36.94 | 19823750 | |
| 978 | Acetylation | SHSKVSAKNNLILAI HCCCCCCCCCHHHHH | 38.57 | 24489116 | |
| 978 | Ubiquitination | SHSKVSAKNNLILAI HCCCCCCCCCHHHHH | 38.57 | 17644757 | |
| 987 | Acetylation | NLILAILKHYQPLCK CHHHHHHHHCHHHHH | 33.87 | 24489116 | |
| 987 | Ubiquitination | NLILAILKHYQPLCK CHHHHHHHHCHHHHH | 33.87 | 17644757 | |
| 998 | Ubiquitination | PLCKLSSKVSAIFST HHHHHCCCHHHHHCC | 49.88 | 24961812 | |
| 1016 | Acetylation | HIVELESKATAKVAL HHHHHCCHHHHHHHH | 40.14 | 24489116 | |
| 1016 | Ubiquitination | HIVELESKATAKVAL HHHHHCCHHHHHHHH | 40.14 | 17644757 | |
| 1038 | Acetylation | QGALPSVKERTEQIE HCCCCCHHHHHHHHH | 45.90 | 24489116 | |
| 1038 | Ubiquitination | QGALPSVKERTEQIE HCCCCCHHHHHHHHH | 45.90 | 23749301 | |
| 1049 | Acetylation | EQIEHILKSSVVKVA HHHHHHHHHCCEEEE | 39.83 | 24489116 | |
| 1054 | Acetylation | ILKSSVVKVAYGSSN HHHHCCEEEECCCCC | 20.99 | 22865919 | |
| 1059 | Phosphorylation | VVKVAYGSSNPKRSE CEEEECCCCCCCCCC | 17.79 | 27717283 | |
| 1060 | Phosphorylation | VKVAYGSSNPKRSEP EEEECCCCCCCCCCC | 53.43 | 23749301 | |
| 1063 | Ubiquitination | AYGSSNPKRSEPDLN ECCCCCCCCCCCCHH | 73.19 | 23749301 | |
| 1114 | Phosphorylation | RRAYRAYTIGDIRVH HHHHHCEEECCEEEE | 19.94 | 22369663 | |
| 1132 | Ubiquitination | TVPIVEWKFQLPSAA EEEEEEEEEECCCHH | 15.10 | 17644757 | |
| 1137 | Phosphorylation | EWKFQLPSAAFSTFP EEEEECCCHHHCCCC | 40.60 | 19779198 | |
| 1141 | Phosphorylation | QLPSAAFSTFPTVKS ECCCHHHCCCCCHHH | 25.14 | 21551504 | |
| 1142 | Phosphorylation | LPSAAFSTFPTVKSK CCCHHHCCCCCHHHH | 27.47 | 19779198 | |
| 1145 | Phosphorylation | AAFSTFPTVKSKMGM HHHCCCCCHHHHCCC | 36.05 | 29136822 | |
| 1147 | Ubiquitination | FSTFPTVKSKMGMNR HCCCCCHHHHCCCCC | 47.00 | 17644757 | |
| 1148 | Phosphorylation | STFPTVKSKMGMNRA CCCCCHHHHCCCCCC | 24.44 | 21082442 | |
| 1157 | Phosphorylation | MGMNRAVSVSDLSYV CCCCCCEEHHHHHHH | 18.21 | 22369663 | |
| 1159 | Phosphorylation | MNRAVSVSDLSYVAN CCCCEEHHHHHHHHC | 25.90 | 22369663 | |
| 1162 | Phosphorylation | AVSVSDLSYVANSQS CEEHHHHHHHHCCCC | 23.66 | 22369663 | |
| 1163 | Phosphorylation | VSVSDLSYVANSQSS EEHHHHHHHHCCCCC | 15.75 | 22369663 | |
| 1167 | Phosphorylation | DLSYVANSQSSPLRE HHHHHHCCCCCCCHH | 23.00 | 29136822 | |
| 1169 | Phosphorylation | SYVANSQSSPLREGI HHHHCCCCCCCHHCH | 33.47 | 29136822 | |
| 1170 | Phosphorylation | YVANSQSSPLREGIL HHHCCCCCCCHHCHH | 21.95 | 19779198 | |
| 1202 | Phosphorylation | EVIPRHQSSSNGPAP EEECCCCCCCCCCCC | 29.61 | 23749301 | |
| 1203 | Phosphorylation | VIPRHQSSSNGPAPD EECCCCCCCCCCCCC | 22.66 | 23749301 | |
| 1250 | Acetylation | REILDLNKQELINAS HHHHCCCHHHHHHHH | 53.07 | 24489116 | |
| 1250 | Ubiquitination | REILDLNKQELINAS HHHHCCCHHHHHHHH | 53.07 | 17644757 | |
| 1274 | Acetylation | FKDGSYPKYYTFNGP CCCCCCCCEEEECCC | 42.53 | 24489116 | |
| 1274 | Ubiquitination | FKDGSYPKYYTFNGP CCCCCCCCEEEECCC | 42.53 | 23749301 | |
| 1311 | Acetylation | RLSNFNIKPIFTDNR CCCCCCEECCCCCCC | 32.92 | 24489116 | |
| 1311 | Ubiquitination | RLSNFNIKPIFTDNR CCCCCCEECCCCCCC | 32.92 | 24961812 | |
| 1328 | Ubiquitination | HVYEAVSKTSPLDKR EEEEECCCCCCCCHH | 46.56 | 17644757 | |
| 1330 | Phosphorylation | YEAVSKTSPLDKRFF EEECCCCCCCCHHHC | 27.48 | 23749301 | |
| 1461 | Ubiquitination | TEMYTEVKNAKGEWV EEEEEEEECCCCCEE | 44.98 | 23749301 | |
| 1464 | Succinylation | YTEVKNAKGEWVFKS EEEEECCCCCEEECC | 67.75 | 23954790 | |
| 1470 | Acetylation | AKGEWVFKSLGKPGS CCCCEEECCCCCCCC | 34.84 | 24489116 | |
| 1474 | Ubiquitination | WVFKSLGKPGSMHLR EEECCCCCCCCEECC | 52.04 | 23749301 | |
| 1485 | Phosphorylation | MHLRPIATPYPVKEW EECCCCCCCCCHHHH | 24.87 | 21440633 | |
| 1499 | Ubiquitination | WLQPKRYKAHLMGTT HHCCCCCCHHHCCCE | 33.10 | 17644757 | |
| 1524 | Acetylation | QASSSQWKNFSADVK HCCCCHHCCCCCCCE | 40.24 | 24489116 | |
| 1524 | Ubiquitination | QASSSQWKNFSADVK HCCCCHHCCCCCCCE | 40.24 | 23749301 | |
| 1572 | Acetylation | VAFKITVKTPEYPRG EEEEEEEECCCCCCC | 50.11 | 24489116 | |
| 1572 | Ubiquitination | VAFKITVKTPEYPRG EEEEEEEECCCCCCC | 50.11 | 23749301 | |
| 1592 | Ubiquitination | VANDITFKIGSFGPQ EECEEEEEECCCCCC | 37.19 | 17644757 | |
| 1606 | Ubiquitination | QEDEFFNKVTEYARK CHHHHHHHHHHHHHH | 45.43 | 23749301 | |
| 1625 | Phosphorylation | RIYLAANSGARIGMA EEEEECCCCCCCCCH | 29.15 | 21440633 | |
| 1655 | Phosphorylation | NPDKGFQYLYLTSEG CCCCCCEEEEEECHH | 8.61 | 27017623 | |
| 1657 | Phosphorylation | DKGFQYLYLTSEGME CCCCEEEEEECHHHH | 11.73 | 27017623 | |
| 1659 | Phosphorylation | GFQYLYLTSEGMETL CCEEEEEECHHHHHH | 15.92 | 27017623 | |
| 1671 | Acetylation | ETLKKFDKENSVLTE HHHHHHCCCCCCCCE | 63.03 | 24489116 | |
| 1671 | Ubiquitination | ETLKKFDKENSVLTE HHHHHHCCCCCCCCE | 63.03 | 23749301 | |
| 1691 | Ubiquitination | GEERFVIKTIIGSED CEEEEEEEEEECCCC | 28.50 | 15699485 | |
| 1716 | Phosphorylation | GLIAGATSRAYHDIF CCCCCCCCCCCCCCE | 17.87 | 28889911 | |
| 1732 | Phosphorylation | ITLVTCRSVGIGAYL EEEEEECCCCHHHHH | 27.17 | 21440633 | |
| 1764 | Acetylation | TGAPAINKMLGREVY ECHHHHHHHCCCEEC | 29.41 | 24489116 | |
| 1764 | Ubiquitination | TGAPAINKMLGREVY ECHHHHHHHCCCEEC | 29.41 | 23749301 | |
| 1813 | Acetylation | WMSYVPAKRNMPVPI HHHCCCCCCCCCCCE | 37.93 | 24489116 | |
| 1813 | Ubiquitination | WMSYVPAKRNMPVPI HHHCCCCCCCCCCCE | 37.93 | 23749301 | |
| 1823 | Phosphorylation | MPVPILETKDTWDRP CCCCEEECCCCCCCC | 30.67 | 19795423 | |
| 1824 | Acetylation | PVPILETKDTWDRPV CCCEEECCCCCCCCC | 43.73 | 24489116 | |
| 1824 | Ubiquitination | PVPILETKDTWDRPV CCCEEECCCCCCCCC | 43.73 | 17644757 | |
| 1826 | Phosphorylation | PILETKDTWDRPVDF CEEECCCCCCCCCCC | 30.71 | 19779198 | |
| 1834 | Phosphorylation | WDRPVDFTPTNDETY CCCCCCCCCCCCCCE | 25.41 | 23749301 | |
| 1854 | Phosphorylation | IEGRETESGFEYGLF EECEECCCCCEEECC | 57.09 | 28889911 | |
| 2034 | Acetylation | PQGMVGIKFRREKLL CCCCCEEEECHHHHH | 27.22 | 24489116 | |
| 2034 | Ubiquitination | PQGMVGIKFRREKLL CCCCCEEEECHHHHH | 27.22 | 23749301 | |
| 2039 | Acetylation | GIKFRREKLLDTMNR EEEECHHHHHHHHHH | 53.16 | 24489116 | |
| 2039 | Ubiquitination | GIKFRREKLLDTMNR EEEECHHHHHHHHHH | 53.16 | 23749301 | |
| 2061 | Acetylation | LRSQLSNKSLAPEVH HHHHHHCCCCCHHHH | 43.39 | 24489116 | |
| 2061 | Ubiquitination | LRSQLSNKSLAPEVH HHHHHHCCCCCHHHH | 43.39 | 23749301 | |
| 2062 | Phosphorylation | RSQLSNKSLAPEVHQ HHHHHCCCCCHHHHH | 33.73 | 21440633 | |
| 2072 | Phosphorylation | PEVHQQISKQLADRE HHHHHHHHHHHHHHH | 15.26 | 21440633 | |
| 2073 | Acetylation | EVHQQISKQLADRER HHHHHHHHHHHHHHH | 51.46 | 24489116 | |
| 2073 | Ubiquitination | EVHQQISKQLADRER HHHHHHHHHHHHHHH | 51.46 | 24961812 | |
| 2106 | Ubiquitination | RSSRMVAKGVISKEL HHHHHHHHCCCCHHC | 42.15 | 23749301 | |
| 2111 | Acetylation | VAKGVISKELEWTEA HHHCCCCHHCCHHHH | 56.01 | 24489116 | |
| 2134 | Phosphorylation | RRRLNEEYLIKRLSH HHHCCHHHHHHHHHH | 13.93 | 27017623 | |
| 2137 | Acetylation | LNEEYLIKRLSHQVG CCHHHHHHHHHHHHC | 44.70 | 24489116 | |
| 2137 | Succinylation | LNEEYLIKRLSHQVG CCHHHHHHHHHHHHC | 44.70 | 23954790 | |
| 2137 | Ubiquitination | LNEEYLIKRLSHQVG CCHHHHHHHHHHHHC | 44.70 | 23793018 | |
| 2140 | Phosphorylation | EYLIKRLSHQVGEAS HHHHHHHHHHHCCHH | 18.86 | 22369663 | |
| 2147 | Phosphorylation | SHQVGEASRLEKIAR HHHHCCHHHHHHHHH | 32.85 | 22369663 | |
| 2151 | Ubiquitination | GEASRLEKIARIRSW CCHHHHHHHHHHHHC | 46.38 | 17644757 | |
| 2180 | Acetylation | TWIEENYKTLDDKLK HHHHHHHCCHHHHHH | 54.94 | 24489116 | |
| 2185 | Ubiquitination | NYKTLDDKLKGLKLE HHCCHHHHHHCCCHH | 52.33 | 23749301 | |
| 2187 | Ubiquitination | KTLDDKLKGLKLESF CCHHHHHHCCCHHHH | 68.86 | 17644757 | |
| 2190 | Acetylation | DDKLKGLKLESFAQD HHHHHCCCHHHHHHH | 59.90 | 24489116 | |
| 2190 | Ubiquitination | DDKLKGLKLESFAQD HHHHHCCCHHHHHHH | 59.90 | 17644757 | |
| 2193 | Phosphorylation | LKGLKLESFAQDLAK HHCCCHHHHHHHHHH | 36.00 | 30377154 | |
| 2200 | Acetylation | SFAQDLAKKIRSDHD HHHHHHHHHHHCCCH | 56.90 | 24489116 | |
| 2200 | Ubiquitination | SFAQDLAKKIRSDHD HHHHHHHHHHHCCCH | 56.90 | 23749301 | |
| 2201 | Ubiquitination | FAQDLAKKIRSDHDN HHHHHHHHHHCCCHH | 37.43 | 17644757 | |
| 2204 | Phosphorylation | DLAKKIRSDHDNAID HHHHHHHCCCHHHHH | 42.65 | 21440633 | |
| 2214 | Phosphorylation | DNAIDGLSEVIKMLS HHHHHHHHHHHHHHC | 35.03 | 27017623 | |
| 2218 | Acetylation | DGLSEVIKMLSTDDK HHHHHHHHHHCCCCH | 38.68 | 24489116 | |
| 2218 | Ubiquitination | DGLSEVIKMLSTDDK HHHHHHHHHHCCCCH | 38.68 | 17644757 | |
| 2221 | Phosphorylation | SEVIKMLSTDDKEKL HHHHHHHCCCCHHHH | 26.71 | 23749301 | |
| 2222 | Phosphorylation | EVIKMLSTDDKEKLL HHHHHHCCCCHHHHH | 44.23 | 21440633 | |
| 2225 | Ubiquitination | KMLSTDDKEKLLKTL HHHCCCCHHHHHHHC | 60.60 | 23749301 | |
| 2227 | Acetylation | LSTDDKEKLLKTLK- HCCCCHHHHHHHCC- | 65.93 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACAC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACAC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACAC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; THR-233; SER-430;THR-1114; THR-1145; SER-1148; SER-1157; SER-1159; SER-1162; TYR-1163AND SER-1169, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1148, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1157, AND MASSSPECTROMETRY. | |
| "A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1157, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1157, AND MASSSPECTROMETRY. | |
