| UniProt ID | RIB1_YEAST | |
|---|---|---|
| UniProt AC | P38066 | |
| Protein Name | GTP cyclohydrolase-2 | |
| Gene Name | RIB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 345 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.. | |
| Protein Sequence | MTIDNYDNSKQDSSKYEVSGTGDGRNGDGGLPLVQCVARARIPTTQGPDIFLHLYSNNRDNKEHLAIVFGEDIRSRSLFRRRQCETQQDRMIRGAYIGKLYPGRTVADEDDRLGLALEFDDSTGELLASKATTWDAHNDTLVRIHSECYTGENAWSARCDCGEQFDRAGRLIACDHEPTSNIKGGNGHGVIVYLRQEGRGIGLGEKLKAYNLQDLGADTVQANLMLKHPVDARDFSLGKAILLDLGIGNVRLLTNNPEKIKQVDHAPYLKCVERVPMVPIHWTNSSEGIDSKEIEGYLRTKIERMGHLLTEPLKLHTNPQPTETSEAQNQNRMNSALSSTSTLAI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 210 | Phosphorylation | LGEKLKAYNLQDLGA HHHHHHHCCCHHCCC | 18.15 | 27017623 | |
| 219 | Phosphorylation | LQDLGADTVQANLML CHHCCCCCHHHHHEE | 17.62 | 27017623 | |
| 259 | Acetylation | LLTNNPEKIKQVDHA ECCCCHHHHHCCCCC | 57.36 | 24489116 | |
| 283 | Phosphorylation | PMVPIHWTNSSEGID CEECCEECCCCCCCC | 15.85 | 22369663 | |
| 285 | Phosphorylation | VPIHWTNSSEGIDSK ECCEECCCCCCCCHH | 23.53 | 22369663 | |
| 286 | Phosphorylation | PIHWTNSSEGIDSKE CCEECCCCCCCCHHH | 41.74 | 22369663 | |
| 291 | Phosphorylation | NSSEGIDSKEIEGYL CCCCCCCHHHHHHHH | 30.21 | 22369663 | |
| 335 | Phosphorylation | QNQNRMNSALSSTST HHHHHHHHHHHHCCC | 22.65 | 22369663 | |
| 338 | Phosphorylation | NRMNSALSSTSTLAI HHHHHHHHHCCCCCC | 31.14 | 22369663 | |
| 339 | Phosphorylation | RMNSALSSTSTLAI- HHHHHHHHCCCCCC- | 27.51 | 22369663 | |
| 340 | Phosphorylation | MNSALSSTSTLAI-- HHHHHHHCCCCCC-- | 23.50 | 22369663 | |
| 341 | Phosphorylation | NSALSSTSTLAI--- HHHHHHCCCCCC--- | 24.30 | 22369663 | |
| 342 | Phosphorylation | SALSSTSTLAI---- HHHHHCCCCCC---- | 21.94 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RIB1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RIB1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RIB1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PDXH_YEAST | YPR172W | physical | 11283351 | |
| RIB1_YEAST | RIB1 | physical | 18467557 | |
| RIB1_YEAST | RIB1 | physical | 18719252 | |
| RIB1_YEAST | RIB1 | physical | 22615397 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285, AND MASSSPECTROMETRY. | |
