| UniProt ID | VPS36_YEAST | |
|---|---|---|
| UniProt AC | Q06696 | |
| Protein Name | Vacuolar protein-sorting-associated protein 36 | |
| Gene Name | VPS36 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 566 | |
| Subcellular Localization |
Cytoplasm . Endosome membrane Peripheral membrane protein . |
|
| Protein Description | Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Involved in the trafficking of the plasma membrane ATPase. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes.. | |
| Protein Sequence | MEYWHYVETTSSGQPLLREGEKDIFIDQSVGLYHGKSKILQRQRGRIFLTSQRIIYIDDAKPTQNSLGLELDDLAYVNYSSGFLTRSPRLILFFKDPSSKDELGKSAETASADVVSTWVCPICMVSNETQGEFTKDTLPTPICINCGVPADYELTKSSINCSNAIDPNANPQNQFGVNSENICPACTFANHPQIGNCEICGHRLPNASKVRSKLNRLNFHDSRVHIELEKNSLARNKSSHSALSSSSSTGSSTEFVQLSFRKSDGVLFSQATERALENILTEKNKHIFNQNVVSVNGVDMRKGASSHEYNNEVPFIETKLSRIGISSLEKSRENQLLNNDILFNNALTDLNKLMSLATSIERLYKNSNITMKTKTLNLQDESTVNEPKTRRPLLILDREKFLNKELFLDEIAREIYEFTLSEFKDLNSDTNYMIITLVDLYAMYNKSMRIGTGLISPMEMREACERFEHLGLNELKLVKVNKRILCVTSEKFDVVKEKLVDLIGDNPGSDLLRLTQILSSNNSKSNWTLGILMEVLQNCVDEGDLLIDKQLSGIYYYKNSYWPSHI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 238 | Phosphorylation | NSLARNKSSHSALSS CCCCCCCCCCCCCCC | 36.51 | 28889911 | |
| 239 | Phosphorylation | SLARNKSSHSALSSS CCCCCCCCCCCCCCC | 24.07 | 28889911 | |
| 241 | Phosphorylation | ARNKSSHSALSSSSS CCCCCCCCCCCCCCC | 32.62 | 28889911 | |
| 244 | Phosphorylation | KSSHSALSSSSSTGS CCCCCCCCCCCCCCC | 28.08 | 28889911 | |
| 245 | Phosphorylation | SSHSALSSSSSTGSS CCCCCCCCCCCCCCC | 34.78 | 28889911 | |
| 248 | Phosphorylation | SALSSSSSTGSSTEF CCCCCCCCCCCCCEE | 38.44 | 28889911 | |
| 251 | Phosphorylation | SSSSSTGSSTEFVQL CCCCCCCCCCEEEEE | 33.89 | 28889911 | |
| 252 | Phosphorylation | SSSSTGSSTEFVQLS CCCCCCCCCEEEEEE | 33.05 | 19779198 | |
| 253 | Phosphorylation | SSSTGSSTEFVQLSF CCCCCCCCEEEEEEE | 34.83 | 28889911 | |
| 259 | Phosphorylation | STEFVQLSFRKSDGV CCEEEEEEEECCCCC | 13.10 | 28889911 | |
| 358 | Phosphorylation | NKLMSLATSIERLYK HHHHHHHHHHHHHHH | 35.21 | 19779198 | |
| 364 | Phosphorylation | ATSIERLYKNSNITM HHHHHHHHHCCCCEE | 17.84 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS36_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS36_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS36_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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