| UniProt ID | PIB1_YEAST | |
|---|---|---|
| UniProt AC | Q06651 | |
| Protein Name | E3 ubiquitin-protein ligase PIB1 | |
| Gene Name | PIB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 286 | |
| Subcellular Localization |
Endosome membrane Peripheral membrane protein. Vacuole membrane Peripheral membrane protein. |
|
| Protein Description | Functions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate.. | |
| Protein Sequence | MVIKEDCINNLARWQADEEAHSCFQCKTNFSFLVRRHHCRCCGRIFCSSCTENFVNYNKKRVHALQKKNSDVESPPYRTCNECYDNLLHLNLLVSSTNRDVRLSQTSVPPNALALSAPDSNTDEDAEILEDSVDQSGTACRSEESSQNEEDHFCPICNSDLTQFPDEEETRKHVEDCIQRAENAQQHTNTSDAADDSVKESPAFQNRMLVYKISPNTTDNAIKECPICFENMEPGEKVGRLECLCVFHYKCIKNWFHKRAQMTAAQKGNGHAFVKRNFCPFHDAVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Ubiquitination | ----MVIKEDCINNL ----CCCCHHHHHHH | 35.77 | 24961812 | |
| 59 | Ubiquitination | ENFVNYNKKRVHALQ HHCCCCCHHHHHHHH | 31.43 | 22817900 | |
| 60 | Ubiquitination | NFVNYNKKRVHALQK HCCCCCHHHHHHHHH | 56.89 | 22817900 | |
| 67 | Ubiquitination | KRVHALQKKNSDVES HHHHHHHHCCCCCCC | 55.56 | 22817900 | |
| 68 | Ubiquitination | RVHALQKKNSDVESP HHHHHHHCCCCCCCC | 49.04 | 23749301 | |
| 70 | Phosphorylation | HALQKKNSDVESPPY HHHHHCCCCCCCCCC | 52.49 | 30377154 | |
| 74 | Phosphorylation | KKNSDVESPPYRTCN HCCCCCCCCCCCCHH | 30.90 | 30377154 | |
| 172 | Ubiquitination | PDEEETRKHVEDCIQ CCHHHHHHHHHHHHH | 60.46 | 23749301 | |
| 188 | Phosphorylation | AENAQQHTNTSDAAD HHHHHHHCCCCHHCC | 35.53 | 22369663 | |
| 190 | Phosphorylation | NAQQHTNTSDAADDS HHHHHCCCCHHCCHH | 29.19 | 21440633 | |
| 191 | Phosphorylation | AQQHTNTSDAADDSV HHHHCCCCHHCCHHH | 27.59 | 22369663 | |
| 197 | Phosphorylation | TSDAADDSVKESPAF CCHHCCHHHHCCHHH | 35.32 | 22369663 | |
| 199 | Ubiquitination | DAADDSVKESPAFQN HHCCHHHHCCHHHHC | 57.32 | 23749301 | |
| 201 | Phosphorylation | ADDSVKESPAFQNRM CCHHHHCCHHHHCCE | 18.79 | 23749301 | |
| 217 | Phosphorylation | VYKISPNTTDNAIKE EEECCCCCCCCCHHC | 38.62 | 27017623 | |
| 223 | Ubiquitination | NTTDNAIKECPICFE CCCCCCHHCCCCCEE | 51.34 | 23749301 | |
| 267 | Ubiquitination | AQMTAAQKGNGHAFV HHCHHHHCCCCCEEE | 50.01 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PIB1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PIB1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PIB1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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