URK1_YEAST - dbPTM
URK1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID URK1_YEAST
UniProt AC P27515
Protein Name Uridine kinase
Gene Name URK1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 501
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway..
Protein Sequence MSHRIAPSKERSSSFISILDDETRDTLKANAVMDGEVDVKKTKGKSSRYIPPWTTPYIIGIGGASGSGKTSVAAKIVSSINVPWTVLISLDNFYNPLGPEDRARAFKNEYDFDEPNAINLDLAYKCILNLKEGKRTNIPVYSFVHHNRVPDKNIVIYGASVVVIEGIYALYDRRLLDLMDLKIYVDADLDVCLARRLSRDIVSRGRDLDGCIQQWEKFVKPNAVKFVKPTMKNADAIIPSMSDNATAVNLIINHIKSKLELKSNEHLRELIKLGSSPSQDVLNRNIIHELPPTNQVLSLHTMLLNKNLNCADFVFYFDRLATILLSWALDDIPVAHTNIITPGEHTMENVIACQFDQVTAVNIIRSGDCFMKSLRKTIPNITIGKLLIQSDSQTGEPQLHCEFLPPNIEKFGKVFLMEGQIISGAAMIMAIQVLLDHGIDLEKISVVVYLATEVGIRRILNAFDNKVNIFAGMIISREKLQNHQYKWALTRFFDSKYFGCD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationIAPSKERSSSFISIL
CCCCCCCCCCCHHHC		31.2722369663
13PhosphorylationAPSKERSSSFISILD
CCCCCCCCCCHHHCC		35.1722890988
14PhosphorylationPSKERSSSFISILDD
CCCCCCCCCHHHCCC		28.0422369663
17PhosphorylationERSSSFISILDDETR
CCCCCCHHHCCCCCH		18.3222369663
23PhosphorylationISILDDETRDTLKAN
HHHCCCCCHHHHHHH		40.6222369663
26PhosphorylationLDDETRDTLKANAVM
CCCCCHHHHHHHCEE		27.2019823750
46PhosphorylationVKKTKGKSSRYIPPW
EEECCCCCCCCCCCC		28.8127017623
47PhosphorylationKKTKGKSSRYIPPWT
EECCCCCCCCCCCCC		32.3727017623
49PhosphorylationTKGKSSRYIPPWTTP
CCCCCCCCCCCCCCC		21.5227017623
54PhosphorylationSRYIPPWTTPYIIGI
CCCCCCCCCCEEEEE		24.5427017623
55PhosphorylationRYIPPWTTPYIIGIG
CCCCCCCCCEEEEEC		15.3827017623
57PhosphorylationIPPWTTPYIIGIGGA
CCCCCCCEEEEECCC		11.7727017623
263PhosphorylationKSKLELKSNEHLREL
HHHHHHCCHHHHHHH		61.1428132839
275PhosphorylationRELIKLGSSPSQDVL
HHHHHHCCCCCHHHH		49.8928889911
276PhosphorylationELIKLGSSPSQDVLN
HHHHHCCCCCHHHHC		27.1127738172
278PhosphorylationIKLGSSPSQDVLNRN
HHHCCCCCHHHHCCC		40.7524909858
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of URK1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of URK1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of URK1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DAS2_YEASTDAS2physical
10688190
DAS2_YEASTDAS2physical
11283351
URK1_YEASTURK1physical
11283351
DAS2_YEASTDAS2physical
18719252
URK1_YEASTURK1physical
18719252
PIL1_YEASTPIL1genetic
19269370
HFA1_YEASTHFA1genetic
19269370
SIW14_YEASTSIW14genetic
19269370
2A5D_YEASTRTS1genetic
19269370
DAS2_YEASTDAS2physical
20489023
UPP_YEASTFUR1physical
20489023
CATT_YEASTCTT1genetic
21623372
ALAT_YEASTALT2genetic
21623372
SWC3_YEASTSWC3genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
NHP10_YEASTNHP10genetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
MED20_YEASTSRB2genetic
27708008
IXR1_YEASTIXR1genetic
27708008
ENT4_YEASTENT4genetic
27708008
RDL1_YEASTRDL1genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
NCBP2_YEASTCBC2genetic
27708008
GAL7_YEASTGAL7genetic
27708008
AGP2_YEASTAGP2genetic
27708008
NPL4_YEASTNPL4genetic
27708008
BUD31_YEASTBUD31genetic
27708008
LIN1_YEASTLIN1genetic
27708008
THIK_YEASTPOT1genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
ALY2_YEASTALY2genetic
27708008
DHOM_YEASTHOM6genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ERG3_YEASTERG3genetic
27708008
ELP1_YEASTIKI3genetic
27708008
PUN1_YEASTPUN1genetic
27708008
CTK3_YEASTCTK3genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
RTG1_YEASTRTG1genetic
27708008
TRM11_YEASTTRM11genetic
27708008
RTC1_YEASTRTC1genetic
27708008
YO159_YEASTYOL159Cgenetic
27708008
ELP4_YEASTELP4genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
KES1_YEASTKES1genetic
27708008
EAF3_YEASTEAF3genetic
27708008
AXL1_YEASTAXL1genetic
27708008
UBC9_HUMANUBE2Iphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of URK1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-276 AND SER-278,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.

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