UPP_YEAST - dbPTM
UPP_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UPP_YEAST
UniProt AC P18562
Protein Name Uracil phosphoribosyltransferase
Gene Name FUR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 216
Subcellular Localization
Protein Description Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate..
Protein Sequence MSSEPFKNVYLLPQTNQLLGLYTIIRNKNTTRPDFIFYSDRIIRLLVEEGLNHLPVQKQIVETDTNENFEGVSFMGKICGVSIVRAGESMEQGLRDCCRSVRIGKILIQRDEETALPKLFYEKLPEDISERYVFLLDPMLATGGSAIMATEVLIKRGVKPERIYFLNLICSKEGIEKYHAAFPEVRIVTGALDRGLDENKYLVPGLGDFGDRYYCV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
82PhosphorylationMGKICGVSIVRAGES
CCEECCEEEEECCCH		10.7217287358
105AcetylationCRSVRIGKILIQRDE
HHHCCCCEEEEECCH		31.7824489116
114PhosphorylationLIQRDEETALPKLFY
EEECCHHCCCCHHHH		31.2928889911
118AcetylationDEETALPKLFYEKLP
CHHCCCCHHHHHHCC		52.6724489116
123UbiquitinationLPKLFYEKLPEDISE
CCHHHHHHCCCCHHH		58.9423749301
123AcetylationLPKLFYEKLPEDISE
CCHHHHHHCCCCHHH		58.9424489116
132PhosphorylationPEDISERYVFLLDPM
CCCHHHHHHHHHCHH		7.4830377154
145PhosphorylationPMLATGGSAIMATEV
HHHHCCHHHHHHHHH		18.9030377154
164PhosphorylationGVKPERIYFLNLICS
CCCHHHEEEEEEEEC		14.2922369663
171PhosphorylationYFLNLICSKEGIEKY
EEEEEEECHHHHHHH		27.0922369663
172AcetylationFLNLICSKEGIEKYH
EEEEEECHHHHHHHH		56.3924489116
177AcetylationCSKEGIEKYHAAFPE
ECHHHHHHHHHHCCC		40.1824489116
200AcetylationDRGLDENKYLVPGLG
HCCCCCCCCCCCCCC		37.6024489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UPP_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UPP_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UPP_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG13_YEASTATG13physical
10688190
MPG1_YEASTPSA1physical
16429126
TBA1_YEASTTUB1physical
16429126
TBB_YEASTTUB2physical
16429126
PYR1_YEASTURA2physical
16429126
KPYK1_YEASTCDC19physical
16429126
PYRF_YEASTURA3genetic
12684846
URK1_YEASTURK1physical
11283351
GET3_YEASTGET3physical
18719252
URK1_YEASTURK1physical
18719252
PYRE_YEASTURA5genetic
18832321
CND2_YEASTBRN1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
KRR1_YEASTKRR1genetic
27708008
TECR_YEASTTSC13genetic
27708008
SNU23_YEASTSNU23genetic
27708008
NOP14_YEASTNOP14genetic
27708008
SNU56_YEASTSNU56genetic
27708008
MOB2_YEASTMOB2genetic
27708008
GPI10_YEASTGPI10genetic
27708008
TEL2_YEASTTEL2genetic
27708008
FNTA_YEASTRAM2genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
ESA1_YEASTESA1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
DIB1_YEASTDIB1genetic
27708008
ATG14_YEASTATG14genetic
27708008
NPL4_YEASTNPL4genetic
27708008
ELO2_YEASTELO2genetic
27708008
ATG15_YEASTATG15genetic
27708008
CSM1_YEASTCSM1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
VPS41_YEASTVPS41genetic
27708008
LSM6_YEASTLSM6genetic
27708008
CEM1_YEASTCEM1genetic
27708008
MSH4_YEASTMSH4genetic
27708008
FABG_YEASTOAR1genetic
27708008
PYRD_YEASTURA1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
PYRC_YEASTURA4genetic
27708008
YPT7_YEASTYPT7genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UPP_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.

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