SYH1_YEAST - dbPTM
SYH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYH1_YEAST
UniProt AC Q02875
Protein Name SMY2 homolog 2
Gene Name SYH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 849
Subcellular Localization Cytoplasm . Mitochondrion .
Protein Description
Protein Sequence MNPINSLAFDLHSVKLADANSDTAALSNSNTPTMNNAALLQRPSSIMDSIGVQRVPSPFVPGSNAISGASTVPFNAYDAEITGSPLQISANQENNSAFSAASSNLHMNASSPSVLNKPSSTFPNVAPYLYNATGPAPNVGNQPPPPGIESQWKYIDSNGNIQGPFGTNNMSQWYQGGYFTPTLQICRLATSPEPFGVNDRFIRLGELTTLVNNYQDPFVAFDFIVIRALNAVPLVAPTSSEKQKVESRDLIPVADVHSDDFTYEEILGLKFEDGSYYHETQVWVPVDGRHITKVDRIPKISAYTAPLSTTSSRSNKTTSSHEEKVPSHEEASPEEQEVFSEEGRTVSNITNEEESIVKNPTKQEEESRGSEKEQNILDQVQPEIEEVDRKDVISTADEPKSKDTPQMTSEEQKRFAKAELMAQKLLEEQQRQEEEKKRREEQRKLKKEKKLKQKQKKEEEKLKKKKKEEGKLEKEKQKELLNNILTGDTETPSSENTATSITTNLAPWANKKPEGAVYNQISSALEDLKKENSSKKEKKPNRTQLDREQALKLQKEILSSAQIPKTQTGSAWGIKPQQPIKVDIKGELMKDSTKINSQSKINKANNGDIKPDSTFIEEQKKLWEQVQKKTKKFNRASSLDDFISRTPSPSSSALNSSNTSNAWTTVSSKSTTHIASTMPVAGNQSKSYISLDTLRSSGGLSTATKTKMSDKSKQIGSSTSIPTLKARQVKPSRIPAYPGNASVSKRQEFLRWCRSQLKLNTGVQPDNVLEMLLSLPPGSESKEIIADTIYSYSSTMDGRRFATDFIKKRLECEEEINDPLSWSEVLAMPEGSSEDWEFQVVGKKKGKRF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationSLAFDLHSVKLADAN
CHHEEEECEEEECCC		28.3924961812
21PhosphorylationVKLADANSDTAALSN
EEEECCCCCCHHHCC		37.7528889911
23PhosphorylationLADANSDTAALSNSN
EECCCCCCHHHCCCC		17.4122369663
27PhosphorylationNSDTAALSNSNTPTM
CCCCHHHCCCCCCCC		33.2222369663
29PhosphorylationDTAALSNSNTPTMNN
CCHHHCCCCCCCCCC		38.4124909858
31PhosphorylationAALSNSNTPTMNNAA
HHHCCCCCCCCCCHH		21.6922369663
33PhosphorylationLSNSNTPTMNNAALL
HCCCCCCCCCCHHHH		30.4122369663
44PhosphorylationAALLQRPSSIMDSIG
HHHHHCCHHHHHHCC		34.3830377154
45PhosphorylationALLQRPSSIMDSIGV
HHHHCCHHHHHHCCC		25.3130377154
301PhosphorylationVDRIPKISAYTAPLS
EEECCCEEEEECCCC		22.7328889911
304PhosphorylationIPKISAYTAPLSTTS
CCCEEEEECCCCCCC		22.8628889911
308PhosphorylationSAYTAPLSTTSSRSN
EEEECCCCCCCCCCC		28.6921440633
309PhosphorylationAYTAPLSTTSSRSNK
EEECCCCCCCCCCCC		38.0821440633
310PhosphorylationYTAPLSTTSSRSNKT
EECCCCCCCCCCCCC		22.7121440633
311PhosphorylationTAPLSTTSSRSNKTT
ECCCCCCCCCCCCCC		24.6821440633
312PhosphorylationAPLSTTSSRSNKTTS
CCCCCCCCCCCCCCC		37.3221440633
314PhosphorylationLSTTSSRSNKTTSSH
CCCCCCCCCCCCCCC		44.6321440633
317PhosphorylationTSSRSNKTTSSHEEK
CCCCCCCCCCCCCCC		35.8429136822
318PhosphorylationSSRSNKTTSSHEEKV
CCCCCCCCCCCCCCC		29.8229136822
319PhosphorylationSRSNKTTSSHEEKVP
CCCCCCCCCCCCCCC		34.6229136822
320PhosphorylationRSNKTTSSHEEKVPS
CCCCCCCCCCCCCCC		32.5929136822
324AcetylationTTSSHEEKVPSHEEA
CCCCCCCCCCCCCCC		57.3624489116
327PhosphorylationSHEEKVPSHEEASPE
CCCCCCCCCCCCCHH		46.6622369663
332PhosphorylationVPSHEEASPEEQEVF
CCCCCCCCHHHHHHH		35.8020377248
340PhosphorylationPEEQEVFSEEGRTVS
HHHHHHHCCCCCCEE		39.6622369663
345PhosphorylationVFSEEGRTVSNITNE
HHCCCCCCEECCCCH		38.8622890988
347PhosphorylationSEEGRTVSNITNEEE
CCCCCCEECCCCHHH		23.1522369663
350PhosphorylationGRTVSNITNEEESIV
CCCEECCCCHHHHHC		40.6122369663
355PhosphorylationNITNEEESIVKNPTK
CCCCHHHHHCCCCCH		35.6422890988
361PhosphorylationESIVKNPTKQEEESR
HHHCCCCCHHHHHHC		55.5422369663
367PhosphorylationPTKQEEESRGSEKEQ
CCHHHHHHCCCHHHH		45.2628889911
394PhosphorylationVDRKDVISTADEPKS
CCHHHHCCCCCCCCC		19.8628889911
395PhosphorylationDRKDVISTADEPKSK
CHHHHCCCCCCCCCC		27.3128889911
401PhosphorylationSTADEPKSKDTPQMT
CCCCCCCCCCCCCCC		46.6227017623
404PhosphorylationDEPKSKDTPQMTSEE
CCCCCCCCCCCCHHH		21.1128889911
408PhosphorylationSKDTPQMTSEEQKRF
CCCCCCCCHHHHHHH		27.9524930733
409PhosphorylationKDTPQMTSEEQKRFA
CCCCCCCHHHHHHHH		33.5224930733
600UbiquitinationTKINSQSKINKANNG
CCCCCCCCHHHCCCC		42.5323749301
637PhosphorylationTKKFNRASSLDDFIS
HHHCCCCCCHHHHHH		28.3522890988
638PhosphorylationKKFNRASSLDDFISR
HHCCCCCCHHHHHHC		34.5322369663
644PhosphorylationSSLDDFISRTPSPSS
CCHHHHHHCCCCCCH		30.0522890988
646PhosphorylationLDDFISRTPSPSSSA
HHHHHHCCCCCCHHH		22.7122369663
648PhosphorylationDFISRTPSPSSSALN
HHHHCCCCCCHHHCC		36.4822369663
650PhosphorylationISRTPSPSSSALNSS
HHCCCCCCHHHCCCC		41.0622369663
651PhosphorylationSRTPSPSSSALNSSN
HCCCCCCHHHCCCCC		24.0222369663
652PhosphorylationRTPSPSSSALNSSNT
CCCCCCHHHCCCCCC		40.9022369663
656PhosphorylationPSSSALNSSNTSNAW
CCHHHCCCCCCCCCC		26.3022369663
657PhosphorylationSSSALNSSNTSNAWT
CHHHCCCCCCCCCCE		42.9522369663
659PhosphorylationSALNSSNTSNAWTTV
HHCCCCCCCCCCEEE		25.8821440633
660PhosphorylationALNSSNTSNAWTTVS
HCCCCCCCCCCEEEE		28.8821551504
664PhosphorylationSNTSNAWTTVSSKST
CCCCCCCEEEECCCC		18.2122369663
665PhosphorylationNTSNAWTTVSSKSTT
CCCCCCEEEECCCCC		14.0022369663
667PhosphorylationSNAWTTVSSKSTTHI
CCCCEEEECCCCCCE		29.9221440633
668PhosphorylationNAWTTVSSKSTTHIA
CCCEEEECCCCCCEE		26.7022369663
670PhosphorylationWTTVSSKSTTHIAST
CEEEECCCCCCEEEE		40.2522369663
671PhosphorylationTTVSSKSTTHIASTM
EEEECCCCCCEEEEC		26.5720377248
672PhosphorylationTVSSKSTTHIASTMP
EEECCCCCCEEEECC		20.5522369663
676PhosphorylationKSTTHIASTMPVAGN
CCCCCEEEECCCCCC		25.3322369663
677PhosphorylationSTTHIASTMPVAGNQ
CCCCEEEECCCCCCC		19.2422369663
685PhosphorylationMPVAGNQSKSYISLD
CCCCCCCCCCEEEHH		27.8022369663
686AcetylationPVAGNQSKSYISLDT
CCCCCCCCCEEEHHH		37.2024489116
687PhosphorylationVAGNQSKSYISLDTL
CCCCCCCCEEEHHHH		32.7122369663
688PhosphorylationAGNQSKSYISLDTLR
CCCCCCCEEEHHHHH		9.7722369663
690PhosphorylationNQSKSYISLDTLRSS
CCCCCEEEHHHHHHC		16.3822890988
693PhosphorylationKSYISLDTLRSSGGL
CCEEEHHHHHHCCCC		29.3922890988
696PhosphorylationISLDTLRSSGGLSTA
EEHHHHHHCCCCCCC		36.1319823750
697PhosphorylationSLDTLRSSGGLSTAT
EHHHHHHCCCCCCCC		30.3719823750
701PhosphorylationLRSSGGLSTATKTKM
HHHCCCCCCCCEEEC		21.1919823750
702PhosphorylationRSSGGLSTATKTKMS
HHCCCCCCCCEEECC		43.3119823750
704PhosphorylationSGGLSTATKTKMSDK
CCCCCCCCEEECCCC		39.0619823750
712PhosphorylationKTKMSDKSKQIGSST
EEECCCCCCCCCCCC		34.4827017623
717PhosphorylationDKSKQIGSSTSIPTL
CCCCCCCCCCCCCCE		31.8822369663
718PhosphorylationKSKQIGSSTSIPTLK
CCCCCCCCCCCCCEE		22.4422369663
719PhosphorylationSKQIGSSTSIPTLKA
CCCCCCCCCCCCEEC		32.1622369663
720PhosphorylationKQIGSSTSIPTLKAR
CCCCCCCCCCCEECC		28.6322369663
723PhosphorylationGSSTSIPTLKARQVK
CCCCCCCCEECCCCC		38.9422369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EIF3I_YEASTTIF34physical
16554755
EIF3G_YEASTTIF35physical
11283351
MRM2_YEASTMRM2genetic
27708008
QRI7_YEASTQRI7genetic
27708008
PST2_YEASTPST2genetic
27708008
CGR1_YEASTCGR1genetic
27708008
SET4_YEASTSET4genetic
27708008
YL177_YEASTYLR177Wgenetic
27708008
ENT2_YEASTENT2genetic
27708008
YL456_YEASTYLR456Wgenetic
27708008
ARA2_YEASTARA2genetic
27708008
YM22_YEASTYMR144Wgenetic
27708008
MMT1_YEASTMMT1genetic
27708008
PUB1_YEASTPUB1genetic
27708008
NRK1_YEASTNRK1genetic
27708008
INO4_YEASTINO4genetic
27708008
ISN1_YEASTISN1genetic
27708008
RDL1_YEASTRDL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYH1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347; THR-350; SER-394;SER-638; SER-670; SER-676; SER-687 AND TYR-688, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-638, AND MASSSPECTROMETRY.

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