ISN1_YEAST - dbPTM
ISN1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ISN1_YEAST
UniProt AC Q99312
Protein Name IMP-specific 5'-nucleotidase 1 {ECO:0000303|PubMed:8141771}
Gene Name ISN1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 450
Subcellular Localization
Protein Description IMP-specific 5'-nucleotidase involved in IMP (inosine 5'-phosphate) degradation..
Protein Sequence MSSRYRVEYHLKSHRKDEFIDWVKGLLASPFVLHAVSHEGDYNDDLATTQRVRSQYADIFKDIEGLIKDKIEFDSRNMSQDEIEDGASSQSLNILGQSRLNLLVPSIGTFFTELPLEQAFLWEDSQRAISARRMVAPSFNDIRHILNTAQIFHFKKQENLHNGKVLRLVTFDGDVTLYEDGGSLVYTNPVIPYILKLLRCGINVGIVTAAGYDEAGTYENRLKGLIVALHDSTDIPVSQKQNLTIMGGESSYLFRYYEDPEEDNFGFRQIDKEEWLLPRMKAWSLEDVEKTLDFAERTLNRLRKRLNLPSEISIIRKVRAVGIVPGERYDEASKRQVPVKLDREQLEEIVLTLQNTLESFAPSRRIQFSCFDGGSDVWCDIGGKDLGVRSLQQFYNPESPIQPSETLHVGDQFAPVGSANDFKARLAGCTLWIASPQETVNYLHRLLETD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16AcetylationYHLKSHRKDEFIDWV
ECCHHCCCHHHHHHH		57.0724489116
79PhosphorylationEFDSRNMSQDEIEDG
EECCCCCCHHHCCCC		37.7222369663
88PhosphorylationDEIEDGASSQSLNIL
HHCCCCCCCHHEHHH		34.1422369663
89PhosphorylationEIEDGASSQSLNILG
HCCCCCCCHHEHHHH		24.2122369663
91PhosphorylationEDGASSQSLNILGQS
CCCCCCHHEHHHHHH		25.9022369663
98PhosphorylationSLNILGQSRLNLLVP
HEHHHHHHHHHHEEC		36.6222369663
138PhosphorylationARRMVAPSFNDIRHI
HHHCCCCCHHHHHHH		27.2628152593
390PhosphorylationGKDLGVRSLQQFYNP
CCCCCCCCHHHHCCC		28.2922369663
395PhosphorylationVRSLQQFYNPESPIQ
CCCHHHHCCCCCCCC		26.0122369663
399PhosphorylationQQFYNPESPIQPSET
HHHCCCCCCCCCCCE		28.6720377248
404PhosphorylationPESPIQPSETLHVGD
CCCCCCCCCEEECCC		27.1722369663
406PhosphorylationSPIQPSETLHVGDQF
CCCCCCCEEECCCCC		26.8822369663
418PhosphorylationDQFAPVGSANDFKAR
CCCCCCCCHHHHHHH		24.9222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ISN1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ISN1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ISN1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ISN1_YEASTISN1physical
11283351
HSP71_YEASTSSA1physical
19536198
YEL1_YEASTYEL1genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
AIM4_YEASTAIM4genetic
27708008
SLX5_YEASTSLX5genetic
27708008
POLH_YEASTRAD30genetic
27708008
SPS2_YEASTSPS2genetic
27708008
RTG2_YEASTRTG2genetic
27708008
ASK10_YEASTASK10genetic
27708008
SDS3_YEASTSDS3genetic
27708008
POG1_YEASTPOG1genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
YJ66_YEASTYJR096Wgenetic
27708008
APN1_YEASTAPN1genetic
27708008
SST2_YEASTSST2genetic
27708008
PHO84_YEASTPHO84genetic
27708008
AEP2_YEASTAEP2genetic
27708008
APJ1_YEASTAPJ1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
NOP12_YEASTNOP12genetic
27708008
RTG1_YEASTRTG1genetic
27708008
HMI1_YEASTHMI1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
MDL2_YEASTMDL2genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ISN1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88; SER-89 AND SER-399,AND MASS SPECTROMETRY.

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