KIP1_YEAST - dbPTM
KIP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIP1_YEAST
UniProt AC P28742
Protein Name Kinesin-like protein KIP1
Gene Name KIP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1111
Subcellular Localization Cytoplasm, cytoskeleton, spindle. Spindle microtubules that lie between the poles.
Protein Description Required for assembly of the mitotic spindle. Interact with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediate by KAR3..
Protein Sequence MARSSLPNRRTAQFEANKRRTIAHAPSPSLSNGMHTLTPPTCNNGAATSDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLVDLFKELSSLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQDSKDHGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHSNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSKDTCLKDYIQEIEKLRNDLKNSRNKQGIFITQDQLDLYESNSILIDEQNLKIHNLREQIKKFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVIQQRDFSLENSQKQYNTNQNMQLKISQQVLQTLNTLQGSLNNYNSKCSEVIKGVTEELTRNVNTHKAKHDSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDSTSHYRKDLNEIYQSHQQFLKNLQNDIKSCLDSIGSSILTSINEISQNCTTNLNSMNVLIENQQSGSSKLIKEQDLEIKKLKNDLINERRISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDISSKLRSLPINEFLNKISQTICETCGDDNTIASNPVLTSIKKFQNIICSDIALTNEKIMSLIDEIQSQIETISNENNINLIAINENFNSLCNFILTDYDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEASVIKALPLLDYPKQFQIYRDAENKSKDDTSNSRTCIPNLSTNENFPLSQFSPKTPVPVPDQPLPKVLIPKSINSAKSNRSKTLPNTEGTGRESQNNLKRRFTTEPILKGEETENNDILQNKKLHQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MARSSLPNRRT
----CCCCCCCCCHH		43.2028889911
5Phosphorylation---MARSSLPNRRTA
---CCCCCCCCCHHH		42.1428889911
189PhosphorylationDLFKELSSLNKEYSV
HHHHHHHHCCHHHEE		48.8928889911
213PhosphorylationENLKDLLSDSEDDDP
CCHHHHHCCCCCCCC		46.5221551504
215PhosphorylationLKDLLSDSEDDDPAV
HHHHHCCCCCCCCCC		39.2828889911
381PhosphorylationSLGGMTKTCIIATIS
HCCCCCCEEEEEEEC		10.3619779198
388PhosphorylationTCIIATISPAKISME
EEEEEEECCCCCCHH		17.9119779198
551PhosphorylationLENSQKQYNTNQNMQ
HHHHHHHCCCCHHHH		30.8728889911
670PhosphorylationNLQNDIKSCLDSIGS
HHHHHHHHHHHHHHH		21.9021551504
682PhosphorylationIGSSILTSINEISQN
HHHHHHHHHHHHHHC		21.7021551504
687PhosphorylationLTSINEISQNCTTNL
HHHHHHHHHCCCCCC		14.7921551504
733PhosphorylationLINERRISNQFNQQL
HHHHHHHHHHHHHHH		23.8329734811
952PhosphorylationKTQDEVLSEHCEKLQ
CCHHHHHHHHHHHHH		30.3923749301
1037PhosphorylationNFPLSQFSPKTPVPV
CCCHHHCCCCCCCCC		20.1827017623
1066PhosphorylationNSAKSNRSKTLPNTE
HCCCCCCCCCCCCCC		33.9521440633
1068PhosphorylationAKSNRSKTLPNTEGT
CCCCCCCCCCCCCCC		49.0125752575
1079PhosphorylationTEGTGRESQNNLKRR
CCCCCHHHHHHHHHC		36.5321440633
1088PhosphorylationNNLKRRFTTEPILKG
HHHHHCCCCCCCCCC		28.5621440633
1089PhosphorylationNLKRRFTTEPILKGE
HHHHCCCCCCCCCCC		36.7319779198
1098PhosphorylationPILKGEETENNDILQ
CCCCCCCCCCCCHHH		39.4519779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseCDC20P26309
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KAR3_YEASTKAR3genetic
9201713
TBB_YEASTTUB2genetic
15766794
SLX5_YEASTSLX5physical
17634282
ASE1_YEASTASE1genetic
17765685
CIN8_YEASTCIN8genetic
18628309
BUB3_YEASTBUB3genetic
19339280
KAR3_YEASTKAR3genetic
8224825
IPL1_YEASTIPL1genetic
17765685
MAD2_YEASTMAD2genetic
19339280
MAD3_YEASTMAD3genetic
19339280
CDC20_YEASTCDC20genetic
19339280
CDC14_YEASTCDC14genetic
19339280
FCP1_YEASTFCP1genetic
22037179
SWI6_YEASTSWI6genetic
22037179
SWI4_YEASTSWI4genetic
22037179
CIN8_YEASTCIN8genetic
22037179
CG22_YEASTCLB2genetic
22037179
SPC72_YEASTSPC72physical
22875988
NST1_YEASTNST1physical
22875988
MRM2_YEASTMRM2genetic
27708008
MAL12_YEASTMAL12genetic
27708008
BUD31_YEASTBUD31genetic
27708008
NRG1_YEASTNRG1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
DCOR_YEASTSPE1genetic
27708008
HMDH1_YEASTHMG1genetic
27708008
VPS9_YEASTVPS9genetic
27708008
MAC1_YEASTMAC1genetic
27708008
GCSP_YEASTGCV2genetic
27708008
PUB1_YEASTPUB1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
THI6_YEASTTHI6genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIP1_YEAST

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Related Literatures of Post-Translational Modification

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