dbPTM

HO_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HO_YEAST
UniProt AC	P09932
Protein Name	Homothallic switching endonuclease
Gene Name	HO
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	586
Subcellular Localization	Nucleus .
Protein Description	Initiation of mating type interconversion. This protein is a site-specific endonuclease that cleaves a site in the mat locus on chromosome III. The double-strand break is followed by a unidirectional gene conversion event that replaces the information at the mat locus by information copied from either of the two homologous loci (HMR and HML) that reside at the extremity of the chromosome III. Endonuclease expression takes place in late G1 just before cells enter S phase..
Protein Sequence	MLSENTTILMANGEIKDIANVTANSYVMCADGSAARVINVTQGYQKIYNIQQKTKHRAFEGEPGRLDPRRRTVYQRLALQCTAGHKLSVRVPTKPLLEKSGRNATKYKVRWRNLQQCQTLDGRIIIIPKNHHKTFPMTVEGEFAAKRFIEEMERSKGEYFNFDIEVRDLDYLDAQLRISSCIRFGPVLAGNGVLSKFLTGRSDLVTPAVKSMAWMLGLWLGDSTTKEPEISVDSLDPKLMESLRENAKIWGLYLTVCDDHVPLRAKHVRLHYGDGPDENRKTRNLRKNNPFWKAVTILKFKRDLDGEKQIPEFMYGEHIEVREAFLAGLIDSDGYVVKKGEGPESYKIAIQTVYSSIMDGIVHISRSLGMSATVTTRSAREEIIEGRKVQCQFTYDCNVAGGTTSQNVLSYCRSGHKTREVPPIIKREPVYFSFTDDFQGESTVYGLTIEGHKNFLLGNKIEVKSCRGCCVGEQLKISQKKNLKHCVACPRKGIKYFYKDWSGKNRVCARCYGRYKFSGHHCINCKYVPEAREVKKAKDKGEKLGITPEGLPVKGPECIKCGGILQFDAVRGPHKSCGNNAGARIC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	LMANGEIKDIANVTA EEECCCEEECEECCC	38.49	17644757
46	Ubiquitination	NVTQGYQKIYNIQQK EECCCHHHHHCCHHH	38.38	23749301
53	Ubiquitination	KIYNIQQKTKHRAFE HHHCCHHHHCCCCCC	43.07	23749301
94	Ubiquitination	LSVRVPTKPLLEKSG EEEECCCCCHHHHCC	27.83	17644757
99	Ubiquitination	PTKPLLEKSGRNATK CCCCHHHHCCCCCCC	59.17	17644757
196	Ubiquitination	AGNGVLSKFLTGRSD ECCCHHHHHHCCCCC	39.99	17644757
225	Phosphorylation	LWLGDSTTKEPEISV HHHCCCCCCCCCCCH	37.04	28889911
248	Ubiquitination	ESLRENAKIWGLYLT HHHHHHCCEEEEEEE	51.04	17644757
338	Ubiquitination	DSDGYVVKKGEGPES CCCCCEEECCCCCCH	45.04	17644757
339	Ubiquitination	SDGYVVKKGEGPESY CCCCEEECCCCCCHH	51.05	17644757
352	Phosphorylation	SYKIAIQTVYSSIMD HHHHHHHHHHHHHHH	18.46	28889911
355	Phosphorylation	IAIQTVYSSIMDGIV HHHHHHHHHHHHHHH	14.73	28889911
388	Ubiquitination	EEIIEGRKVQCQFTY HHHHCCCEEEEEEEE	47.73	17644757
453	Ubiquitination	GLTIEGHKNFLLGNK EEEEECCCCEECCCE	61.32	17644757
460	Ubiquitination	KNFLLGNKIEVKSCR CCEECCCEEEEEECC	38.14	17644757
464	Ubiquitination	LGNKIEVKSCRGCCV CCCEEEEEECCCCCC	30.92	17644757
476	Ubiquitination	CCVGEQLKISQKKNL CCCCCCCCCCCCCCC	39.75	17644757
492	Ubiquitination	HCVACPRKGIKYFYK EEEECCCCCCEEEEE	50.56	22817900
495	Ubiquitination	ACPRKGIKYFYKDWS ECCCCCCEEEEECCC	37.67	22817900
499	Ubiquitination	KGIKYFYKDWSGKNR CCCEEEEECCCCCCC	42.70	22817900
504	Ubiquitination	FYKDWSGKNRVCARC EEECCCCCCCEEHHH	35.74	22817900
516	Ubiquitination	ARCYGRYKFSGHHCI HHHCCEEEECCCEEE	31.52	23749301
526	Ubiquitination	GHHCINCKYVPEARE CCEEECCEECCCHHH	44.81	22817900
543	Ubiquitination	KAKDKGEKLGITPEG HHHHCCCCCCCCCCC	61.76	17644757
554	Ubiquitination	TPEGLPVKGPECIKC CCCCCCCCCCCCEEE	67.80	23749301
560	Ubiquitination	VKGPECIKCGGILQF CCCCCCEEECCEEEE	38.19	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RAD18	P10862	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	UFO1	Q04511	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HO_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HO_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UFO1_YEAST	UFO1	physical	14506225
RPN1_YEAST	RPN1	physical	15964793
IMB3_YEAST	PSE1	physical	16507575
KA120_YEAST	KAP120	physical	16507575
UMP1_YEAST	UMP1	genetic	17314980
MSN5_YEAST	MSN5	physical	18807043

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HO_YEAST

Related Literatures of Post-Translational Modification