| UniProt ID | REC8_YEAST | |
|---|---|---|
| UniProt AC | Q12188 | |
| Protein Name | Meiotic recombination protein REC8 | |
| Gene Name | REC8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 680 | |
| Subcellular Localization | Nucleus . Chromosome . Chromosome, centromere . Localizes at chromosome cores during pachytene. Disappears from chromosome arms shortly before the first meiotic division, but persists in the vincinity of centromeres until the onset of anaphase II. | |
| Protein Description | Replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis. Is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate. Is protected from cleavage by SPO13.. | |
| Protein Sequence | MAPLSLNFKDDKKYKGLTTVWLLSALGNSIVKESNNYYSNKSNSTGNISSSTVKKKDIVNISIPKTCDEIQNFENDFSLRYISNLLYGVTICYNKKTEYVLNDLNHLLVQLQKNDVYAFKAKNKSTRINGLNSNNSIIGNKNNNYTWEECVFFDDDPLYDITKVPALEFLNTTLQDNVSFIEEAKSIRRQDYINELSNSNRFELHGDMTNSDAQSNLGSNVRNSFPLDEIPVDVDFNLDLDDIVSHQGTPLGSHSSSQKDGNDFKFNYQGDELVLNFENDNENNSNGGEDTSVENEGPVANLKDYELGLEAQASEEENDLQQKLNTRMQRGHRADVGGQFSKVQFDAKTSYPNEVLKFNHGNYSHLMEKNRIRKLTGQNFLTSNISSLVRSCGEEEFFSTNWLSIFNDFSNIKTSEWDLYPQGFSSVERGRKRAHSLVSTQSSSSTRSHEYGRKSFRNNKNDNYSSDMENDNLLLNLEQINEDLEDGHYIEENSQGNILDFNLNLPPSSFGRSHTRNSTRSSGFNEDIVGALRRRVGPSEQNFAEEDDSSNSCFSDGSQQNLQQDKTNFQDVILDYQTKKFYDYIKERSIVVGRTTRSNPPFKRKMLLVDIIPSRMGEAQTGANFDDVERGVSRQIAASAFLSLLNLATKGMVKLNEYPVADAVTKDLKLRREDEIIVYA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MAPLSLNFKDDK ---CCCCCCCCCCCC | 21.87 | 27214570 | |
| 44 | Phosphorylation | YYSNKSNSTGNISSS CCCCCCCCCCCCCCC | 44.79 | 27214570 | |
| 83 | Phosphorylation | DFSLRYISNLLYGVT HHHHHHHHHHHHEEE | 16.70 | 19779198 | |
| 90 | Phosphorylation | SNLLYGVTICYNKKT HHHHHEEEEECCCCC | 10.85 | 19779198 | |
| 133 | Phosphorylation | TRINGLNSNNSIIGN CCCCCCCCCCCCCCC | 42.29 | 27214570 | |
| 136 | Phosphorylation | NGLNSNNSIIGNKNN CCCCCCCCCCCCCCC | 21.60 | 27214570 | |
| 172 | Phosphorylation | PALEFLNTTLQDNVS CHHHHHCCHHHHHHH | 30.91 | 20230747 | |
| 173 | Phosphorylation | ALEFLNTTLQDNVSF HHHHHCCHHHHHHHH | 22.73 | 20230747 | |
| 179 | Phosphorylation | TTLQDNVSFIEEAKS CHHHHHHHHHHHHHH | 27.10 | 27214570 | |
| 197 | Phosphorylation | QDYINELSNSNRFEL HHHHHHHHCCCCEEE | 31.84 | 20230747 | |
| 209 | Phosphorylation | FELHGDMTNSDAQSN EEEECCCCCHHHHHC | 35.99 | 20230747 | |
| 211 | Phosphorylation | LHGDMTNSDAQSNLG EECCCCCHHHHHCCC | 25.75 | 20230747 | |
| 215 | Phosphorylation | MTNSDAQSNLGSNVR CCCHHHHHCCCCCCC | 35.42 | 27214570 | |
| 219 | Phosphorylation | DAQSNLGSNVRNSFP HHHHCCCCCCCCCCC | 35.01 | 20230747 | |
| 224 | Phosphorylation | LGSNVRNSFPLDEIP CCCCCCCCCCCCCCC | 20.06 | 20230747 | |
| 245 | Phosphorylation | LDLDDIVSHQGTPLG CCHHHHHHCCCCCCC | 15.49 | 20230747 | |
| 285 | Phosphorylation | ENDNENNSNGGEDTS ECCCCCCCCCCCCCC | 48.73 | 20230747 | |
| 292 | Phosphorylation | SNGGEDTSVENEGPV CCCCCCCCCCCCCCC | 39.49 | 20230747 | |
| 314 | Phosphorylation | LGLEAQASEEENDLQ HHHHHHCCHHHHHHH | 33.20 | 27214570 | |
| 386 | Phosphorylation | NFLTSNISSLVRSCG CHHHCCHHHHHHHHC | 23.13 | 20230747 | |
| 387 | Phosphorylation | FLTSNISSLVRSCGE HHHCCHHHHHHHHCC | 27.38 | 20230747 | |
| 425 | Phosphorylation | DLYPQGFSSVERGRK CCCCCCCCHHHHHCH | 40.06 | 20230747 | |
| 426 | Phosphorylation | LYPQGFSSVERGRKR CCCCCCCHHHHHCHH | 26.24 | 20230747 | |
| 436 | Phosphorylation | RGRKRAHSLVSTQSS HHCHHHHHHHCCCCC | 29.49 | 20230747 | |
| 465 | Phosphorylation | NNKNDNYSSDMENDN CCCCCCCCHHCCCCC | 26.56 | 20230747 | |
| 466 | Phosphorylation | NKNDNYSSDMENDNL CCCCCCCHHCCCCCE | 30.53 | 20230747 | |
| 494 | Phosphorylation | GHYIEENSQGNILDF CCCEEECCCCCEEEE | 42.62 | 20230747 | |
| 509 | Phosphorylation | NLNLPPSSFGRSHTR ECCCCHHHCCCCCCC | 37.18 | 27214570 | |
| 521 | Phosphorylation | HTRNSTRSSGFNEDI CCCCCCCCCCCCHHH | 34.60 | 27214570 | |
| 522 | Phosphorylation | TRNSTRSSGFNEDIV CCCCCCCCCCCHHHH | 44.08 | 27214570 | |
| 558 | Phosphorylation | NSCFSDGSQQNLQQD CCCCCCCHHHHHHCC | 33.32 | 20230747 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of REC8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of REC8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of REC8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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