| UniProt ID | CDC5_YEAST | |
|---|---|---|
| UniProt AC | P32562 | |
| Protein Name | Cell cycle serine/threonine-protein kinase CDC5/MSD2 | |
| Gene Name | CDC5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 705 | |
| Subcellular Localization | ||
| Protein Description | Protein kinase required for the cell cycle where it is involved in mitotic exit. A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Phosphorylates SCC1/MCD1 and NET1.. | |
| Protein Sequence | MSLGPLKAINDKQLNTRSKLVHTPIKGNTADLVGKENHFKQTKRLDPNNDHHHQPAQKKKREKLSALCKTPPSLIKTRGKDYHRGHFLGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFRGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESMSSDKIQRQKRDYISSIKSSIDKLEEYHQNRPFLPHSLSPGGTKQKYKEVVDIEAQRRLNDLAREARIRRAQQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGLPKSRLPKIKHPMIVTKWVDYSNKHGFSYQLSTEDIGVLFNNGTTVLRLADAEEFWYISYDDREGWVASHYLLSEKPRELSRHLEVVDFFAKYMKANLSRVSTFGREEYHKDDVFLRRYTRYKPFVMFELSDGTFQFNFKDHHKMAISDGGKLVTYISPSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIKEGLKQKSTIVTVD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLGPLKAI ------CCCCCHHCC | 41.87 | 16303563 | |
| 18 | Phosphorylation | DKQLNTRSKLVHTPI HHHCCCCCCEECCCC | 28.44 | 16303563 | |
| 23 | Phosphorylation | TRSKLVHTPIKGNTA CCCCEECCCCCCCHH | 21.16 | 21551504 | |
| 29 | Phosphorylation | HTPIKGNTADLVGKE CCCCCCCHHHHCCCC | 30.16 | 16303563 | |
| 42 | Phosphorylation | KENHFKQTKRLDPNN CCCCCCCCCCCCCCC | 20.79 | 25704821 | |
| 65 | Phosphorylation | KKKREKLSALCKTPP HHHHHHHHHHHCCCH | 30.20 | 21440633 | |
| 70 | Phosphorylation | KLSALCKTPPSLIKT HHHHHHCCCHHHHHC | 39.16 | 19823750 | |
| 73 | Phosphorylation | ALCKTPPSLIKTRGK HHHCCCHHHHHCCCC | 43.88 | 19823750 | |
| 206 | Ubiquitination | RVIHRDLKLGNIFFD CEECCCCCCCCEEEC | 59.65 | 17644757 | |
| 219 | Ubiquitination | FDSNYNLKIGDFGLA ECCCCCEEECCHHHH | 40.79 | 17644757 | |
| 233 | Phosphorylation | AAVLANESERKYTIC HHHHCCCCCCCEEEC | 42.37 | 21440633 | |
| 237 | Phosphorylation | ANESERKYTICGTPN CCCCCCCEEECCCCC | 13.93 | 28889911 | |
| 238 | Phosphorylation | NESERKYTICGTPNY CCCCCCEEECCCCCC | 16.90 | 16303563 | |
| 242 | Phosphorylation | RKYTICGTPNYIAPE CCEEECCCCCCCCCH | 12.16 | 16303563 | |
| 245 | Phosphorylation | TICGTPNYIAPEVLM EECCCCCCCCCHHHC | 10.32 | 19779198 | |
| 364 | Phosphorylation | EDIPEEQSLVNFKDC CCCCHHHCCCCHHHH | 37.25 | 28889911 | |
| 398 | Ubiquitination | RDYISSIKSSIDKLE HHHHHHHHHHHHHHH | 39.85 | 17644757 | |
| 403 | Ubiquitination | SIKSSIDKLEEYHQN HHHHHHHHHHHHHHC | 57.01 | 17644757 | |
| 407 | Phosphorylation | SIDKLEEYHQNRPFL HHHHHHHHHHCCCCC | 10.18 | 29688323 | |
| 417 | Phosphorylation | NRPFLPHSLSPGGTK CCCCCCCCCCCCCCH | 28.71 | 16303563 | |
| 419 | Phosphorylation | PFLPHSLSPGGTKQK CCCCCCCCCCCCHHH | 25.23 | 16303563 | |
| 423 | Phosphorylation | HSLSPGGTKQKYKEV CCCCCCCCHHHHHHH | 35.90 | 16303563 | |
| 424 | Ubiquitination | SLSPGGTKQKYKEVV CCCCCCCHHHHHHHC | 48.33 | 17644757 | |
| 509 | Ubiquitination | KSRLPKIKHPMIVTK HHHCCCCCCCEEEEE | 48.02 | 17644757 | |
| 516 | Ubiquitination | KHPMIVTKWVDYSNK CCCEEEEEEEECCCC | 34.03 | 17644757 | |
| 591 | Ubiquitination | EVVDFFAKYMKANLS HHHHHHHHHHHHHHH | 40.49 | 17644757 | |
| 651 | Ubiquitination | MAISDGGKLVTYISP EEECCCCEEEEEECC | 45.36 | 17644757 | |
| 672 | Ubiquitination | YPLVEVLKYGEIPGY CCCEEHHHHCCCCCC | 57.28 | 17644757 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-23; THR-70; SER-73;THR-238 AND THR-242, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419, AND MASSSPECTROMETRY. | |
