CLU_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLU_YEAST
• UniProt AC: Q03690
• Protein Name: Clustered mitochondria protein 1
• Gene Name: CLU1 {ECO:0000255|HAMAP-Rule:MF_03013}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1277
• Subcellular Localization: Cytoplasm .
• Protein Description: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria..
• Protein Sequence: MSEKKEEVKNATVKVTVKLPKEDNHSHNTKHLKKTQSSKNNDISFEIGKESKIQTVLDVLAMIPSSKYLTNVGLKTIEGDSQLSDEMSIKEIVGEKSELKLQLILKPYSAREALKHVITVRDFIGFAQETSDGLSEFAISTGSSFSSLPLGPIKERSKQEEKDEKSDPEEKKNTFKDVTDEEKLKFNEMVHEVFSSFKNSSINKLLTSESNIITPCVRSLSFAPYNPVPPFYRSKGHLFYLQIVTLEGESFYITAIPSGFYVNKSNSTKFDPSPKENTDENAHSSLIYYSLFDLIASRSKKFISHVQAFEKKLSALDSTSYVRPSNTFLHKPWFVSSLPPNNPDYLRLQTAALDTTPERNFNDEFQAIKDLTTSTLQDRIEMERLFSKVVHEFSVTAASGAMSIFYSDFVAMNPESPTRDQIFLKDNIFYSYVSDVSGNYEGKGGDEAAIAASNQDLKTINILNRLHMHEVRYLLTTVVEFAGRRILAQTPVPGLLATMGNKIVKDANTGEEVTEDFVNDINVKYGLDEGLGKIVYDADFDSVLEKKFVKAFHLKKHKVNGTELAFSSQSKGIVGFDKRRYILDLANTYPLDINFARQNFDNIEETGNRYPHRQTLLRPELVEKWWNNKVEKEGVEFEKAYEENLFSYNPDAYQVEGIEDANVDEMSNYLQKEVIPSVIQDYLSGNLSTPYNGEHLADTLHKNGINMRYLGKIIELSQKELDSQIVHYEQNLKAVEQDNKEYEDWEKSYLQKIENMIKERQAKINKLVQEGKEVPKELTEDLKLNDEEIKKPTDGKPVVVAYDELVPLIKISELEIVSRSLKHVLKDLSKDVPVFLVPSLVAYVFNMLVGINYNADPKPEPVDEFYPVNKCSFAKLTRSELLEAVSKQAFLRFRHQLPSNWIEAYMENPFTLIRSVSYKFGIQLLNKEYFFTREQLESYKQSLDKKIRNKFVEPPTTFSLSDLTIIPRVKFSEYTSSVSEEFWAQGASMINEDKQSALTLLAQSITVLEDVNNILHPAVAEKYLSLSAIYNKLALYPEAIAFCRKACTIYERVSGIDSFEMMRALTNLAILEFSNESPYNATVVYNRLAEILKVYELPKIHHPAPTSIFNHLEQLALGVQDTKLAIEVLGQLSSYVVELEGKDSLAYGYTESRLGNLFAALKDFHRALEHITVTQGIFTKQLGMNHTHSAQSRQWVNGLSSLIMDLKQKKQLAQDQMSTTGSNSAGHKKTNHRQKKDDVKPELANKSVDELLTFIEGDSSNSKSKNKTNNKKKHGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Succinylation	---MSEKKEEVKNAT ---CCHHHHHHHCCE		23954790
30	Acetylation	DNHSHNTKHLKKTQS CCCCCCCCCCHHCCC		25381059
39	Acetylation	LKKTQSSKNNDISFE CHHCCCCCCCCEEEE		24489116
55	Phosphorylation	GKESKIQTVLDVLAM CCHHHHHHHHHHHHH		25521595
65	Phosphorylation	DVLAMIPSSKYLTNV HHHHHCCCCHHHHCC		22369663
66	Phosphorylation	VLAMIPSSKYLTNVG HHHHCCCCHHHHCCC		22369663
68	Phosphorylation	AMIPSSKYLTNVGLK HHCCCCHHHHCCCCC		25521595
70	Phosphorylation	IPSSKYLTNVGLKTI CCCCHHHHCCCCCCC		25521595
81	Phosphorylation	LKTIEGDSQLSDEMS CCCCCCCCCCCCCCC		27017623
88	Phosphorylation	SQLSDEMSIKEIVGE CCCCCCCCHHHHHCC		25521595
96	Ubiquitination	IKEIVGEKSELKLQL HHHHHCCCCHHHHEE		23749301
97	Phosphorylation	KEIVGEKSELKLQLI HHHHCCCCHHHHEEC		17287358
106	Acetylation	LKLQLILKPYSAREA HHHEECCCCCCHHHH		24489116
115	Acetylation	YSAREALKHVITVRD CCHHHHHHHHEHHHH		24489116
166	Phosphorylation	QEEKDEKSDPEEKKN HHHHHCCCCHHHHHC		28889911
183	2-Hydroxyisobutyrylation	KDVTDEEKLKFNEMV CCCCHHHHHHHHHHH		-
221	Phosphorylation	TPCVRSLSFAPYNPV CCCCHHCCCCCCCCC		27214570
269	Ubiquitination	VNKSNSTKFDPSPKE ECCCCCCCCCCCCCC		23749301
278	Phosphorylation	DPSPKENTDENAHSS CCCCCCCCCCCHHHH		27017623
290	Phosphorylation	HSSLIYYSLFDLIAS HHHHHHHHHHHHHHH		27017623
297	Phosphorylation	SLFDLIASRSKKFIS HHHHHHHHCCHHHHH		27017623
301	Ubiquitination	LIASRSKKFISHVQA HHHHCCHHHHHHHHH		17644757
301	Acetylation	LIASRSKKFISHVQA HHHHCCHHHHHHHHH		22865919
311	Ubiquitination	SHVQAFEKKLSALDS HHHHHHHHHHHCCCC		17644757
311	Acetylation	SHVQAFEKKLSALDS HHHHHHHHHHHCCCC		24489116
312	Ubiquitination	HVQAFEKKLSALDST HHHHHHHHHHCCCCC		17644757
350	Phosphorylation	PDYLRLQTAALDTTP CCHHHHHHCCCCCCC		27214570
355	Phosphorylation	LQTAALDTTPERNFN HHHCCCCCCCCCCCC		30377154
356	Phosphorylation	QTAALDTTPERNFND HHCCCCCCCCCCCCH		25752575
369	Ubiquitination	NDEFQAIKDLTTSTL CHHHHHHHHHCCCHH		24961812
490	Phosphorylation	GRRILAQTPVPGLLA CCHHHHCCCCCCHHH		21126336
498	Phosphorylation	PVPGLLATMGNKIVK CCCCHHHHCCCEEEE		28889911
505	Ubiquitination	TMGNKIVKDANTGEE HCCCEEEECCCCCCC		17644757
524	Ubiquitination	FVNDINVKYGLDEGL HHHHHCHHCCCCCCC		17644757
536	Phosphorylation	EGLGKIVYDADFDSV CCCCEEEEECCHHHH		27017623
542	Phosphorylation	VYDADFDSVLEKKFV EEECCHHHHHHHHHH		28152593
546	Acetylation	DFDSVLEKKFVKAFH CHHHHHHHHHHHHHC		24489116
632	Acetylation	WWNNKVEKEGVEFEK HHCCCCHHCCCCCHH		24489116
712	Ubiquitination	INMRYLGKIIELSQK CCHHHHHHHHHHHHH		17644757
712	Acetylation	INMRYLGKIIELSQK CCHHHHHHHHHHHHH		24489116
719	Acetylation	KIIELSQKELDSQIV HHHHHHHHHHHHHHH		24489116
719	Ubiquitination	KIIELSQKELDSQIV HHHHHHHHHHHHHHH		17644757
733	Ubiquitination	VHYEQNLKAVEQDNK HHHHHHHHHHHHCCH		17644757
740	Succinylation	KAVEQDNKEYEDWEK HHHHHCCHHHHHHHH		23954790
740	Acetylation	KAVEQDNKEYEDWEK HHHHHCCHHHHHHHH		24489116
747	Acetylation	KEYEDWEKSYLQKIE HHHHHHHHHHHHHHH		24489116
752	Acetylation	WEKSYLQKIENMIKE HHHHHHHHHHHHHHH		24489116
766	Ubiquitination	ERQAKINKLVQEGKE HHHHHHHHHHHCCCC		23749301
766	Acetylation	ERQAKINKLVQEGKE HHHHHHHHHHHCCCC		22865919
772	Ubiquitination	NKLVQEGKEVPKELT HHHHHCCCCCCHHHH		23749301
812	Phosphorylation	LVPLIKISELEIVSR CCCEEEHHHHHHHHH		19823750
818	Phosphorylation	ISELEIVSRSLKHVL HHHHHHHHHHHHHHH		19795423
820	Phosphorylation	ELEIVSRSLKHVLKD HHHHHHHHHHHHHHH		19795423
875	Acetylation	VNKCSFAKLTRSELL CCCCCHHHCCHHHHH		25381059
887	Ubiquitination	ELLEAVSKQAFLRFR HHHHHHHHHHHHHHH		24961812
887	Acetylation	ELLEAVSKQAFLRFR HHHHHHHHHHHHHHH		24489116
938	Phosphorylation	FTREQLESYKQSLDK CCHHHHHHHHHHHCH		28889911
940	Succinylation	REQLESYKQSLDKKI HHHHHHHHHHHCHHH		23954790
950	Acetylation	LDKKIRNKFVEPPTT HCHHHHHHCCCCCCC		24489116
950	Ubiquitination	LDKKIRNKFVEPPTT HCHHHHHHCCCCCCC		17644757
1023	Phosphorylation	HPAVAEKYLSLSAIY CHHHHHHHHCHHHHH		19823750
1025	Phosphorylation	AVAEKYLSLSAIYNK HHHHHHHCHHHHHHH		19823750
1027	Phosphorylation	AEKYLSLSAIYNKLA HHHHHCHHHHHHHHC		19795423
1030	Phosphorylation	YLSLSAIYNKLALYP HHCHHHHHHHHCCCH		19795423
1032	Ubiquitination	SLSAIYNKLALYPEA CHHHHHHHHCCCHHH		17644757
1045	Ubiquitination	EAIAFCRKACTIYER HHHHHHHHHCHHHHH		17644757
1093	Acetylation	NRLAEILKVYELPKI HHHHHHHHHCCCCCC		24489116
1162	Acetylation	GNLFAALKDFHRALE HHHHHHHHHHHHHHH		24489116
1180	Ubiquitination	VTQGIFTKQLGMNHT EECCCCCCCCCCCCC		17644757
1187	Phosphorylation	KQLGMNHTHSAQSRQ CCCCCCCCCHHHHHH		19823750
1189	Phosphorylation	LGMNHTHSAQSRQWV CCCCCCCHHHHHHHH		19823750
1192	Phosphorylation	NHTHSAQSRQWVNGL CCCCHHHHHHHHHHH		19823750
1200	Phosphorylation	RQWVNGLSSLIMDLK HHHHHHHHHHHHHHH		19823750
1201	Phosphorylation	QWVNGLSSLIMDLKQ HHHHHHHHHHHHHHH		19823750
1207	Acetylation	SSLIMDLKQKKQLAQ HHHHHHHHHHHHHHH		24489116
1218	Phosphorylation	QLAQDQMSTTGSNSA HHHHHHHHCCCCCCC		21440633
1219	Phosphorylation	LAQDQMSTTGSNSAG HHHHHHHCCCCCCCC		21440633
1220	Phosphorylation	AQDQMSTTGSNSAGH HHHHHHCCCCCCCCC		28889911
1222	Phosphorylation	DQMSTTGSNSAGHKK HHHHCCCCCCCCCCC		28889911
1228	Acetylation	GSNSAGHKKTNHRQK CCCCCCCCCCCCCCC		25381059
1247	Phosphorylation	KPELANKSVDELLTF CHHHHCCCHHHHHHH		22369663
1253	Phosphorylation	KSVDELLTFIEGDSS CCHHHHHHHHCCCCC		28889911
1259	Phosphorylation	LTFIEGDSSNSKSKN HHHHCCCCCCCCCCC		28889911
1260	Phosphorylation	TFIEGDSSNSKSKNK HHHCCCCCCCCCCCC		21440633
1262	Phosphorylation	IEGDSSNSKSKNKTN HCCCCCCCCCCCCCC		30377154
1263	Acetylation	EGDSSNSKSKNKTNN CCCCCCCCCCCCCCC		24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLU_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLU_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLU_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3G_YEAST	TIF35	physical	10358023
GBLP_YEAST	ASC1	physical	16429126
TAD3_YEAST	TAD3	genetic	19061648
USA1_YEAST	USA1	genetic	19061648
SAP30_YEAST	SAP30	genetic	19061648
HIR2_YEAST	HIR2	genetic	19061648
CSK22_YEAST	CKA2	genetic	19061648
SKI7_YEAST	SKI7	genetic	19061648
EFTU_YEAST	TUF1	genetic	19061648
NOT3_YEAST	NOT3	genetic	19061648
HSP71_YEAST	SSA1	physical	19536198
HIR2_YEAST	HIR2	genetic	19547744
ZDS1_YEAST	ZDS1	genetic	19547744
NOT3_YEAST	NOT3	genetic	19547744
RQC2_YEAST	TAE2	genetic	20691087
PMP1_YEAST	PMP1	physical	26404137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.