PAM1_YEAST - dbPTM
PAM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PAM1_YEAST
UniProt AC P37304
Protein Name Protein PAM1
Gene Name PAM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 830
Subcellular Localization
Protein Description Not known. It is a suppressor of protein phosphatase 2A depletion..
Protein Sequence MTSALRVLVCGDHPNLILYTSRFQHAKNIEFYLVNNSKNANYEVSSLFYGTERFQIQNHFQSLLDLVDLNNENGGLVFDLIIMSASSLQEIPQVLRDIKPMMNKTTKILFESSGFIYLEPFIKASVDLSLSNIFSIFTDYDIRRLDNGSYKQFTTANAKSFSVSIGQTTSVHENSYSSDIIPILNTFQKLFQKLFPRDVVTLYDHSPSAFLAKEWELALPQICFDPLLIILEEKNPSTLDDHVLAKPLISGLLGESLLIIKKMGIAMNNPNFQNEQTILKHWKNKCEDLPDGPALLYNFIHKASSLNIDLLLLQPILLADDFGVKTPYLECLFTMMTQYQLLNKGDSEWFIRKDENTALTRVDDLQNSIALKDGKIMQLQNSESTLKNEIKELQSQVLSLKQEVSSSKANNGQELEILKKKVQMGDNSLFDRPNSNTNGISPSDNIVDVDLNYERSDQGNNSSGNDSRRQSFFNSTSDTTLSRDETSLKERELEVRMKELELQERELELQRKALQQQQQYQQRPPKQVYSGPSGTPTSGNNNNKSYNPNRKSSYSQPQHVAMMTSRGLHGPSAASSSPVISANNFVDPVSSGTPYSSNSSRFSQQIPSQQYMHTVKPTSRKNRSSVMPNIGYVPGLTNNEYGRKFNGNGMNGTQSRLNSLSNQSTFRSQQGPPITQQKSFQNNGGSMRTNRIPSANYNISNQQSGFVNSISSPNLSNLENRNTVQNSRNADSAPCVNQLNSDSPPQLQSLSQNGTSKVPQINITQPSPIQTNFATSDNPAAVIKLGTPSEDTVSAAATANNISTMGDESRKEDVKEKKKKKFSFFGKRKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTSALRVLV
------CCCEEEEEE		23.7830377154
19PhosphorylationDHPNLILYTSRFQHA
CCCCEEEEECCCCCC		8.8230377154
20PhosphorylationHPNLILYTSRFQHAK
CCCEEEEECCCCCCC		15.2430377154
21PhosphorylationPNLILYTSRFQHAKN
CCEEEEECCCCCCCC		19.9630377154
149PhosphorylationIRRLDNGSYKQFTTA
EEECCCCCEEEEEEC		35.1027214570
150PhosphorylationRRLDNGSYKQFTTAN
EECCCCCEEEEEECC		15.3727214570
193AcetylationTFQKLFQKLFPRDVV
HHHHHHHHHCCCCCE		44.7724489116
250PhosphorylationVLAKPLISGLLGESL
HHHHHHHHHHHCCHH		30.9519795423
256PhosphorylationISGLLGESLLIIKKM
HHHHHCCHHHHHHHH		27.0319795423
283UbiquitinationQTILKHWKNKCEDLP
HHHHHHHHHCCCCCC		46.3717644757
285UbiquitinationILKHWKNKCEDLPDG
HHHHHHHCCCCCCCC		34.9617644757
302UbiquitinationLLYNFIHKASSLNID
HHHHHHHHHHHCCHH		45.1817644757
326PhosphorylationADDFGVKTPYLECLF
HCCCCCCCHHHHHHH		18.1128889911
334PhosphorylationPYLECLFTMMTQYQL
HHHHHHHHHHHHHHH		7.9628889911
339PhosphorylationLFTMMTQYQLLNKGD
HHHHHHHHHHHCCCC		7.6128889911
360PhosphorylationKDENTALTRVDDLQN
CCCCCCCEEHHHHHH		26.6128889911
368PhosphorylationRVDDLQNSIALKDGK
EHHHHHHHEECCCCC		9.0425752575
372UbiquitinationLQNSIALKDGKIMQL
HHHHEECCCCCEEEE		56.2523749301
375UbiquitinationSIALKDGKIMQLQNS
HEECCCCCEEEECCC		45.1723749301
382PhosphorylationKIMQLQNSESTLKNE
CEEEECCCHHHHHHH		21.6930377154
385PhosphorylationQLQNSESTLKNEIKE
EECCCHHHHHHHHHH		37.3928889911
405PhosphorylationLSLKQEVSSSKANNG
HHHHHHHHHHCCCCC		28.3019823750
406PhosphorylationSLKQEVSSSKANNGQ
HHHHHHHHHCCCCCC		40.8219823750
407PhosphorylationLKQEVSSSKANNGQE
HHHHHHHHCCCCCCC		28.4219823750
408UbiquitinationKQEVSSSKANNGQEL
HHHHHHHCCCCCCCH		58.0223749301
462PhosphorylationRSDQGNNSSGNDSRR
CCCCCCCCCCCHHHH		43.5516445868
463PhosphorylationSDQGNNSSGNDSRRQ
CCCCCCCCCCHHHHH		43.6816445868
471PhosphorylationGNDSRRQSFFNSTSD
CCHHHHHHHHCCCCC		29.9622369663
475PhosphorylationRRQSFFNSTSDTTLS
HHHHHHCCCCCCCCC		24.9122369663
476PhosphorylationRQSFFNSTSDTTLSR
HHHHHCCCCCCCCCC		31.5522369663
477PhosphorylationQSFFNSTSDTTLSRD
HHHHCCCCCCCCCCC		32.5522369663
479PhosphorylationFFNSTSDTTLSRDET
HHCCCCCCCCCCCCC		29.4222369663
480PhosphorylationFNSTSDTTLSRDETS
HCCCCCCCCCCCCCC		27.9422369663
482PhosphorylationSTSDTTLSRDETSLK
CCCCCCCCCCCCCHH		35.2819779198
486PhosphorylationTTLSRDETSLKEREL
CCCCCCCCCHHHHHH		43.5819779198
487PhosphorylationTLSRDETSLKERELE
CCCCCCCCHHHHHHH		35.0822369663
512UbiquitinationRELELQRKALQQQQQ
HHHHHHHHHHHHHHH		40.2523749301
526UbiquitinationQYQQRPPKQVYSGPS
HHHHCCCCCCCCCCC		55.8923749301
530PhosphorylationRPPKQVYSGPSGTPT
CCCCCCCCCCCCCCC		45.4222369663
533PhosphorylationKQVYSGPSGTPTSGN
CCCCCCCCCCCCCCC		59.8423749301
535PhosphorylationVYSGPSGTPTSGNNN
CCCCCCCCCCCCCCC		27.9422369663
537PhosphorylationSGPSGTPTSGNNNNK
CCCCCCCCCCCCCCC		49.4521440633
538PhosphorylationGPSGTPTSGNNNNKS
CCCCCCCCCCCCCCC		40.5022369663
544UbiquitinationTSGNNNNKSYNPNRK
CCCCCCCCCCCCCCC		57.3423749301
552PhosphorylationSYNPNRKSSYSQPQH
CCCCCCCCCCCCHHH		31.1328889911
553PhosphorylationYNPNRKSSYSQPQHV
CCCCCCCCCCCHHHH		31.6617330950
555PhosphorylationPNRKSSYSQPQHVAM
CCCCCCCCCHHHHEE		37.0128889911
572PhosphorylationSRGLHGPSAASSSPV
HCCCCCCCCCCCCCE		40.8521440633
575PhosphorylationLHGPSAASSSPVISA
CCCCCCCCCCCEEEC		30.9423749301
576PhosphorylationHGPSAASSSPVISAN
CCCCCCCCCCEEECC		33.6523749301
577PhosphorylationGPSAASSSPVISANN
CCCCCCCCCEEECCC		22.2323749301
581PhosphorylationASSSPVISANNFVDP
CCCCCEEECCCCCCC		25.7723749301
590PhosphorylationNNFVDPVSSGTPYSS
CCCCCCCCCCCCCCC		28.5623749301
591PhosphorylationNFVDPVSSGTPYSSN
CCCCCCCCCCCCCCC		47.0923749301
593PhosphorylationVDPVSSGTPYSSNSS
CCCCCCCCCCCCCCH		22.4723749301
624PhosphorylationPTSRKNRSSVMPNIG
CCCCCCCCCCCCCCC		36.3628889911
625PhosphorylationTSRKNRSSVMPNIGY
CCCCCCCCCCCCCCC		21.1428889911
653PhosphorylationNGNGMNGTQSRLNSL
CCCCCCCCHHHHHHH		20.5421440633
655PhosphorylationNGMNGTQSRLNSLSN
CCCCCCHHHHHHHHC		38.2824930733
659PhosphorylationGTQSRLNSLSNQSTF
CCHHHHHHHHCHHHH		37.4522369663
661PhosphorylationQSRLNSLSNQSTFRS
HHHHHHHHCHHHHHC		32.4222890988
664PhosphorylationLNSLSNQSTFRSQQG
HHHHHCHHHHHCCCC		33.4922890988
665PhosphorylationNSLSNQSTFRSQQGP
HHHHCHHHHHCCCCC		17.1922890988
668PhosphorylationSNQSTFRSQQGPPIT
HCHHHHHCCCCCCCC		23.7523749301
678UbiquitinationGPPITQQKSFQNNGG
CCCCCCCCCCCCCCC		43.3423749301
679PhosphorylationPPITQQKSFQNNGGS
CCCCCCCCCCCCCCC		27.9422369663
686PhosphorylationSFQNNGGSMRTNRIP
CCCCCCCCCCCCCCC		13.3922369663
700PhosphorylationPSANYNISNQQSGFV
CCCCCCCCCCCCCCC		25.5822369663
704PhosphorylationYNISNQQSGFVNSIS
CCCCCCCCCCCCCCC		25.1622369663
709PhosphorylationQQSGFVNSISSPNLS
CCCCCCCCCCCCCHH		20.6722369663
711PhosphorylationSGFVNSISSPNLSNL
CCCCCCCCCCCHHHC		39.2922369663
712PhosphorylationGFVNSISSPNLSNLE
CCCCCCCCCCHHHCC		19.0122369663
716PhosphorylationSISSPNLSNLENRNT
CCCCCCHHHCCCCCC		46.1122369663
732PhosphorylationQNSRNADSAPCVNQL
CCCCCCCCCCCHHHC		31.5322369663
741PhosphorylationPCVNQLNSDSPPQLQ
CCHHHCCCCCCHHHH		48.3230377154
743PhosphorylationVNQLNSDSPPQLQSL
HHHCCCCCCHHHHHH		38.0023749301
749PhosphorylationDSPPQLQSLSQNGTS
CCCHHHHHHHCCCCC		38.2823749301
751PhosphorylationPPQLQSLSQNGTSKV
CHHHHHHHCCCCCCC		27.1830377154
755PhosphorylationQSLSQNGTSKVPQIN
HHHHCCCCCCCCCCE		32.6825704821
756PhosphorylationSLSQNGTSKVPQINI
HHHCCCCCCCCCCEE		32.8127017623
764PhosphorylationKVPQINITQPSPIQT
CCCCCEECCCCCCCC		29.9119823750
767PhosphorylationQINITQPSPIQTNFA
CCEECCCCCCCCCCC		25.4725521595
771PhosphorylationTQPSPIQTNFATSDN
CCCCCCCCCCCCCCC		32.7821440633
775PhosphorylationPIQTNFATSDNPAAV
CCCCCCCCCCCCCEE		32.2629688323
776PhosphorylationIQTNFATSDNPAAVI
CCCCCCCCCCCCEEE		31.7729688323
787PhosphorylationAAVIKLGTPSEDTVS
CEEEECCCCCHHHHH		33.7922369663
789PhosphorylationVIKLGTPSEDTVSAA
EEECCCCCHHHHHHH		48.2022369663
792PhosphorylationLGTPSEDTVSAAATA
CCCCCHHHHHHHHHH		16.5922369663
794PhosphorylationTPSEDTVSAAATANN
CCCHHHHHHHHHHCC		17.8122369663
798PhosphorylationDTVSAAATANNISTM
HHHHHHHHHCCCCCC		25.7822369663
803PhosphorylationAATANNISTMGDESR
HHHHCCCCCCCCHHH		17.9222369663
804PhosphorylationATANNISTMGDESRK
HHHCCCCCCCCHHHH		22.7522369663
809PhosphorylationISTMGDESRKEDVKE
CCCCCCHHHHHHHHH		54.0822369663
823PhosphorylationEKKKKKFSFFGKRKK
HHHHHCCCCCCCCCC		28.6621440633
827AcetylationKKFSFFGKRKK----
HCCCCCCCCCC----		56.7522865919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PAM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PAM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PAM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RLA3_YEASTRPP1Bphysical
16554755
G3P1_YEASTTDH1physical
16554755
CLH_YEASTCHC1physical
20489023
PKH3_YEASTPKH3physical
20489023
TAF1_YEASTTAF1physical
22875988
NNF1_YEASTNNF1physical
22875988
END3_YEASTEND3physical
22875988
CTF19_YEASTCTF19physical
22875988
CSN12_YEASTYJR084Wgenetic
27708008
AVT5_YEASTAVT5genetic
27708008
MBA1_YEASTMBA1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
RV161_YEASTRVS161genetic
27708008
MTU1_YEASTSLM3genetic
27708008
PEX19_YEASTPEX19genetic
27708008
ARO1_YEASTARO1genetic
27708008
BCS1_YEASTBCS1genetic
27708008
SNF1_YEASTSNF1genetic
27708008
ODPA_YEASTPDA1genetic
27708008
MED5_YEASTNUT1genetic
27708008
MTO1_YEASTMTO1genetic
27708008
UBCX_YEASTPEX4genetic
27708008
DAL81_YEASTDAL81genetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
HAP4_YEASTHAP4genetic
27708008
ATP10_YEASTATP10genetic
27708008
MAC1_YEASTMAC1genetic
27708008
MSS1_YEASTMSS1genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
ATP23_YEASTATP23genetic
27708008
PHO80_YEASTPHO80genetic
27708008
CY1_YEASTCYT1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
RTC6_YEASTRTC6genetic
27708008
MED1_YEASTMED1genetic
27708008
AXL1_YEASTAXL1genetic
27708008
SVL3_YEASTSVL3genetic
29211891
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PAM1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368; SER-475; SER-477;SER-487; SER-659; SER-661; SER-711; SER-712; SER-767 AND THR-771, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-462 AND SER-463, ANDMASS SPECTROMETRY.

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