ORM1_YEAST - dbPTM
ORM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ORM1_YEAST
UniProt AC P53224
Protein Name Protein ORM1
Gene Name ORM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 222
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis. Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity..
Protein Sequence MTELDYQGTAEAASTSYSRNQTDLKPFPSAGSASSSIKTTEPVKDHRRRRSSSIISHVEPETFEDENDQQLLPNMNATWVDQRGAWIIHVVIIILLKLFYNLFPGVTTEWSWTLTNMTYVIGSYVMFHLIKGTPFDFNGGAYDNLTMWEQIDDETLYTPSRKFLISVPIALFLVSTHYAHYDLKLFSWNCFLTTFGAVVPKLPVTHRLRISIPGITGRAQIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTELDYQGT
------CCCCCCCCC		45.3028889911
14PhosphorylationQGTAEAASTSYSRNQ
CCCHHHHCCCCCCCC		25.5728889911
15PhosphorylationGTAEAASTSYSRNQT
CCHHHHCCCCCCCCC		27.2727017623
16PhosphorylationTAEAASTSYSRNQTD
CHHHHCCCCCCCCCC		20.7228889911
17PhosphorylationAEAASTSYSRNQTDL
HHHHCCCCCCCCCCC		16.2528889911
18PhosphorylationEAASTSYSRNQTDLK
HHHCCCCCCCCCCCC		25.2328889911
22PhosphorylationTSYSRNQTDLKPFPS
CCCCCCCCCCCCCCC		47.0122369663
25AcetylationSRNQTDLKPFPSAGS
CCCCCCCCCCCCCCC		47.6324489116
29PhosphorylationTDLKPFPSAGSASSS
CCCCCCCCCCCCCCC		45.7122369663
32PhosphorylationKPFPSAGSASSSIKT
CCCCCCCCCCCCCCC		25.3722369663
34PhosphorylationFPSAGSASSSIKTTE
CCCCCCCCCCCCCCC		26.7322369663
35PhosphorylationPSAGSASSSIKTTEP
CCCCCCCCCCCCCCC		35.4822369663
36PhosphorylationSAGSASSSIKTTEPV
CCCCCCCCCCCCCCC		26.1322369663
39PhosphorylationSASSSIKTTEPVKDH
CCCCCCCCCCCCCCC		34.4228889911
40PhosphorylationASSSIKTTEPVKDHR
CCCCCCCCCCCCCCC		33.0328889911
51PhosphorylationKDHRRRRSSSIISHV
CCCCHHHCCCCHHCC		26.9919779198
52PhosphorylationDHRRRRSSSIISHVE
CCCHHHCCCCHHCCC		24.6019779198
53PhosphorylationHRRRRSSSIISHVEP
CCHHHCCCCHHCCCC		25.7819779198
56PhosphorylationRRSSSIISHVEPETF
HHCCCCHHCCCCCCC		21.5828889911
62PhosphorylationISHVEPETFEDENDQ
HHCCCCCCCCCCCCC		42.9419779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ORM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ORM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ORM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ORM2_YEASTORM2genetic
16269340
PMA1_YEASTPMA1genetic
16269340
SCS7_YEASTSCS7genetic
16269340
COG7_YEASTCOG7genetic
16269340
YGB0_YEASTMPO1genetic
16269340
TRS20_YEASTTRS20genetic
16269340
ERG4_YEASTERG4genetic
16269340
NNF2_YEASTNNF2genetic
16269340
PMT4_YEASTPMT4genetic
16269340
GET1_YEASTGET1genetic
16269340
CWH41_YEASTCWH41genetic
16269340
PLMT_YEASTOPI3genetic
16269340
GST1_YEASTGTT1physical
18719252
USA1_YEASTUSA1physical
18719252
ORM2_YEASTORM2genetic
20212121
DS1P1_YEASTLCB3genetic
20212121
RSB1_YEASTRSB1genetic
20212121
LCB1_YEASTLCB1physical
20212121
DGK1_YEASTDGK1genetic
20212121
SCS2_YEASTSCS2genetic
20212121
LCB1_YEASTLCB1physical
20182505
LCB2_YEASTLCB2physical
20182505
SAC1_YEASTSAC1physical
20182505
TSC3_YEASTTSC3physical
20182505
SAC1_YEASTSAC1genetic
20182505
ORM2_YEASTORM2physical
20182505
ORM2_YEASTORM2genetic
20182505
LCB2_YEASTLCB2genetic
20182505
ORM1_YEASTORM1physical
20182505
TSC3_YEASTTSC3genetic
21196517
LAC1_YEASTLAC1physical
22328531
IRE1_YEASTIRE1genetic
22328531
SLT2_YEASTSLT2genetic
22328531
MID2_YEASTMID2genetic
22328531
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
ORM2_YEASTORM2genetic
23286903
ORM2_YEASTORM2physical
23363605
LCB1_YEASTLCB1physical
23363605
LCB2_YEASTLCB2physical
23363605
SAC1_YEASTSAC1physical
23363605
ORM2_YEASTORM2genetic
25040056
IRE1_YEASTIRE1genetic
23737533
CANB_YEASTCNB1genetic
23737533
CCH1_YEASTCCH1genetic
23737533
CRZ1_YEASTCRZ1genetic
23737533
DS1P1_YEASTLCB3genetic
27561298
NOP14_YEASTNOP14genetic
27708008
BCP1_YEASTBCP1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
PRP43_YEASTPRP43genetic
27708008
SPC97_YEASTSPC97genetic
27708008
TIM14_YEASTPAM18genetic
27708008
SDO1_YEASTSDO1genetic
27708008
NUF2_YEASTNUF2genetic
27708008
TBF1_YEASTTBF1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
DHAS_YEASTHOM2genetic
27708008
YJ24_YEASTKCH1genetic
27708008
ORM2_YEASTORM2genetic
27708008
ELO3_YEASTELO3genetic
28145511
AUR1_YEASTAUR1genetic
28145511
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ORM1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-34 AND SER-36,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29 AND SER-32, AND MASSSPECTROMETRY.

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