TRPE_YEAST - dbPTM
TRPE_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRPE_YEAST
UniProt AC P00899
Protein Name Anthranilate synthase component 1
Gene Name TRP2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 507
Subcellular Localization
Protein Description
Protein Sequence MTASIKIQPDIDSLKQLQQQNDDSSINMYPVYAYLPSLDLTPHVAYLKLAQLNNPDRKESFLLESAKTNNELDRYSFIGISPRKTIKTGPTEGIETDPLEILEKEMSTFKVAENVPGLPKLSGGAIGYISYDCVRYFEPKTRRPLKDVLRLPEAYLMLCDTIIAFDNVFQRFQIIHNINTNETSLEEGYQAAAQIITDIVSKLTDDSSPIPYPEQPPIKLNQTFESNVGKEGYENHVSTLKKHIKKGDIIQGVPSQRVARPTSLHPFNIYRHLRTVNPSPYLFYIDCLDFQIIGASPELLCKSDSKNRVITHPIAGTVKRGATTEEDDALADQLRGSLKDRAEHVMLVDLARNDINRICDPLTTSVDKLLTIQKFSHVQHLVSQVSGVLRPEKTRFDAFRSIFPAGTVSGAPKVRAMELIAELEGERRGVYAGAVGHWSYDGKTMDNCIALRTMVYKDGIAYLQAGGGIVYDSDEYDEYVETMNKMMANHSTIVQAEELWADIVGSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTASIKIQP
------CCCEEEECC		29.1619823750
4Phosphorylation----MTASIKIQPDI
----CCCEEEECCCH		18.4319823750
13PhosphorylationKIQPDIDSLKQLQQQ
EECCCHHHHHHHHHC		37.4919823750
58AcetylationQLNNPDRKESFLLES
HHCCCCHHHHHHHHH		66.1624489116
65PhosphorylationKESFLLESAKTNNEL
HHHHHHHHHHCCCCC		34.7328889911
68PhosphorylationFLLESAKTNNELDRY
HHHHHHHCCCCCCCE		42.8928889911
76PhosphorylationNNELDRYSFIGISPR
CCCCCCEEEEEECCC		15.9821126336
81PhosphorylationRYSFIGISPRKTIKT
CEEEEEECCCCCCCC		17.2822369663
208PhosphorylationSKLTDDSSPIPYPEQ
HHHCCCCCCCCCCCC		33.5727214570
223PhosphorylationPPIKLNQTFESNVGK
CCCCCCCCCCCCCCC		28.4428889911
226PhosphorylationKLNQTFESNVGKEGY
CCCCCCCCCCCCHHH		32.4030377154
230AcetylationTFESNVGKEGYENHV
CCCCCCCCHHHHHHH		43.6224489116
255PhosphorylationDIIQGVPSQRVARPT
CCCCCCCCCCCCCCC		28.3630377154
323PhosphorylationGTVKRGATTEEDDAL
CCCCCCCCCHHHHHH		37.2522369663
324PhosphorylationTVKRGATTEEDDALA
CCCCCCCCHHHHHHH		36.5222369663
337PhosphorylationLADQLRGSLKDRAEH
HHHHHHHHHHHHHHH		26.3022369663
363PhosphorylationNRICDPLTTSVDKLL
HHHCCCCCCCHHHHH		23.5519823750
364PhosphorylationRICDPLTTSVDKLLT
HHCCCCCCCHHHHHH		34.1419823750
365PhosphorylationICDPLTTSVDKLLTI
HCCCCCCCHHHHHHH		24.0819823750
368UbiquitinationPLTTSVDKLLTIQKF
CCCCCHHHHHHHHHH		43.1523749301
368AcetylationPLTTSVDKLLTIQKF
CCCCCHHHHHHHHHH		43.1524489116
371PhosphorylationTSVDKLLTIQKFSHV
CCHHHHHHHHHHHHH		31.6221440633
401PhosphorylationTRFDAFRSIFPAGTV
CCHHHHHHHCCCCCC		23.3328889911
407PhosphorylationRSIFPAGTVSGAPKV
HHHCCCCCCCCCCHH		17.3828889911
409PhosphorylationIFPAGTVSGAPKVRA
HCCCCCCCCCCHHHH		29.1328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRPE_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRPE_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRPE_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
METK1_YEASTSAM1physical
11805826
TRPG_YEASTTRP3physical
11805826
TRPG_YEASTTRP3physical
16554755
RPN1_YEASTRPN1physical
16429126
METK1_YEASTSAM1physical
16429126
TRPG_YEASTTRP3physical
16429126
COPB2_YEASTSEC27physical
18467557
BNA3_YEASTBNA3physical
18467557
ECM33_YEASTECM33genetic
20093466
IST2_YEASTIST2genetic
20093466
YB8B_YEASTYBR287Wgenetic
20093466
STE50_YEASTSTE50genetic
20093466
SNT1_YEASTSNT1genetic
20093466
YD157_YEASTYDL157Cgenetic
20093466
THI3_YEASTTHI3genetic
20093466
MKC7_YEASTMKC7genetic
20093466
PUS3_YEASTDEG1genetic
20093466
MED5_YEASTNUT1genetic
20093466
MPC1_YEASTMPC1genetic
20093466
TBP7_YEASTYTA7genetic
20093466
SOL3_YEASTSOL3genetic
20093466
OYE2_YEASTOYE2genetic
20093466
PTH_YEASTPTH1genetic
20093466
SAC1_YEASTSAC1genetic
20093466
SRL3_YEASTSRL3genetic
20093466
RL8B_YEASTRPL8Bgenetic
20093466
ERG3_YEASTERG3genetic
20093466
CSF1_YEASTCSF1genetic
20093466
SRN2_YEASTSRN2genetic
20093466
ELO3_YEASTELO3genetic
20093466
ERG6_YEASTERG6genetic
20093466
ERG2_YEASTERG2genetic
20093466
PET8_YEASTPET8genetic
20093466
MED9_YEASTCSE2genetic
20093466
INO4_YEASTINO4genetic
20093466
TAT2_YEASTTAT2genetic
20093466
TOP1_YEASTTOP1genetic
20093466
SYC1_YEASTSYC1genetic
20093466
FUMH_YEASTFUM1genetic
20093466
KES1_YEASTKES1genetic
20093466
RL21B_YEASTRPL21Bgenetic
20093466
GGPPS_YEASTBTS1genetic
20093466
LGE1_YEASTLGE1genetic
20093466
MSS18_YEASTMSS18genetic
20093466
COX6_YEASTCOX6genetic
21623372
SYSM_YEASTDIA4genetic
21623372
ERG6_YEASTERG6genetic
21623372
ACON_YEASTACO1genetic
21623372
ATP14_YEASTATP14genetic
21623372
ATPO_YEASTATP5genetic
21623372
COX10_YEASTCOX10genetic
21623372
GLG2_YEASTGLG2genetic
21623372
QCR7_YEASTQCR7genetic
21623372
TPS2_YEASTTPS2genetic
21623372
COQ2_YEASTCOQ2genetic
21623372
COPB2_YEASTSEC27physical
22615397
ERT1_YEASTERT1genetic
27708008
IMG2_YEASTIMG2genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
HRB1_YEASTHRB1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
DPOD_YEASTPOL3genetic
27708008
CDC53_YEASTCDC53genetic
27708008
TIM22_YEASTTIM22genetic
27708008
CDC13_YEASTCDC13genetic
27708008
UBC3_YEASTCDC34genetic
27708008
PDC2_YEASTPDC2genetic
27708008
CDC37_YEASTCDC37genetic
27708008
SYMC_YEASTMES1genetic
27708008
CWC16_YEASTYJU2genetic
27708008
GRC3_YEASTGRC3genetic
27708008
SED5_YEASTSED5genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CDC3_YEASTCDC3genetic
27708008
TAD3_YEASTTAD3genetic
27708008
PGA3_YEASTPGA3genetic
27708008
LST8_YEASTLST8genetic
27708008
OST2_YEASTOST2genetic
27708008
ULP1_YEASTULP1genetic
27708008
ASA1_YEASTASA1genetic
27708008
NPL4_YEASTNPL4genetic
27708008
CLPX_YEASTMCX1genetic
27708008
DPH7_YEASTRRT2genetic
27708008
YB8B_YEASTYBR287Wgenetic
27708008
STE50_YEASTSTE50genetic
27708008
SNT1_YEASTSNT1genetic
27708008
ELO2_YEASTELO2genetic
27708008
THRC_YEASTTHR4genetic
27708008
CYPR_YEASTCPR4genetic
27708008
BDF2_YEASTBDF2genetic
27708008
VAM6_YEASTVAM6genetic
27708008
DLHH_YEASTYDL086Wgenetic
27708008
PMT5_YEASTPMT5genetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
RLA3_YEASTRPP1Bgenetic
27708008
YD157_YEASTYDL157Cgenetic
27708008
OMS1_YEASTOMS1genetic
27708008
MPC1_YEASTMPC1genetic
27708008
MED5_YEASTNUT1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
NPR3_YEASTNPR3genetic
27708008
YHH7_YEASTYSC83genetic
27708008
SOL3_YEASTSOL3genetic
27708008
OYE2_YEASTOYE2genetic
27708008
PTH_YEASTPTH1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
I23O_YEASTBNA2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
SAC1_YEASTSAC1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
ERG3_YEASTERG3genetic
27708008
SRN2_YEASTSRN2genetic
27708008
ERG6_YEASTERG6genetic
27708008
PKR1_YEASTPKR1genetic
27708008
ERG2_YEASTERG2genetic
27708008
PET8_YEASTPET8genetic
27708008
TAT2_YEASTTAT2genetic
27708008
RRP6_YEASTRRP6genetic
27708008
PT127_YEASTPET127genetic
27708008
BUB3_YEASTBUB3genetic
27708008
SYC1_YEASTSYC1genetic
27708008
PALA_YEASTRIM20genetic
27708008
FSH3_YEASTFSH3genetic
27708008
ALDH6_YEASTALD6genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
RU2A_YEASTLEA1genetic
27708008
FUMH_YEASTFUM1genetic
27708008
HAA1_YEASTHAA1genetic
27708008
YP098_YEASTYPR098Cgenetic
27708008
MSS18_YEASTMSS18genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRPE_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 AND THR-223, AND MASSSPECTROMETRY.

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