TAT2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAT2_YEAST
• UniProt AC: P38967
• Protein Name: Tryptophan permease
• Gene Name: TAT2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 592
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine..
• Protein Sequence: MTEDFISSVKRSNEELKERKSNFGFVEYKSKQLTSSSSHNSNSSHHDDDNQHGKRNIFQRCVDSFKSPLDGSFDTSNLKRTLKPRHLIMIAIGGSIGTGLFVGSGKAIAEGGPLGVVIGWAIAGSQIIGTIHGLGEITVRFPVVGAFANYGTRFLDPSISFVVSTIYVLQWFFVLPLEIIAAAMTVQYWNSSIDPVIWVAIFYAVIVSINLFGVRGFGEAEFAFSTIKAITVCGFIILCVVLICGGGPDHEFIGAKYWHDPGCLANGFPGVLSVLVVASYSLGGIEMTCLASGETDPKGLPSAIKQVFWRILFFFLISLTLVGFLVPYTNQNLLGGSSVDNSPFVIAIKLHHIKALPSIVNAVILISVLSVGNSCIFASSRTLCSMAHQGLIPWWFGYIDRAGRPLVGIMANSLFGLLAFLVKSGSMSEVFNWLMAIAGLATCIVWLSINLSHIRFRLAMKAQGKSLDELEFVSAVGIWGSAYSALINCLILIAQFYCSLWPIGGWTSGKERAKIFFQNYLCALIMLFIFIVHKIYYKCQTGKWWGVKALKDIDLETDRKDIDIEIVKQEIAEKKMYLDSRPWYVRQFHFWC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	EDFISSVKRSNEELK HHHHHHHHHCHHHHH	52.65	25381059
17	Ubiquitination	KRSNEELKERKSNFG HHCHHHHHHHHHCCC	59.77	23749301
20	Ubiquitination	NEELKERKSNFGFVE HHHHHHHHHCCCCCE	51.33	22817900
21	Phosphorylation	EELKERKSNFGFVEY HHHHHHHHCCCCCEE	43.54	21440633
72	Phosphorylation	FKSPLDGSFDTSNLK CCCCCCCCCCCHHHH	21.44	19779198
75	Phosphorylation	PLDGSFDTSNLKRTL CCCCCCCCHHHHHHC	19.94	27017623
79	Ubiquitination	SFDTSNLKRTLKPRH CCCCHHHHHHCCCCE	47.81	23749301
83	Ubiquitination	SNLKRTLKPRHLIMI HHHHHHCCCCEEEEE	39.12	22817900
461	Acetylation	IRFRLAMKAQGKSLD HHHHHHHHHCCCCHH	31.76	25381059
584	Phosphorylation	YLDSRPWYVRQFHFW CCCCCCCEEEEEECC	6.61	20377248

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RSP5	P39940	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAT2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAT2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRPF_YEAST	TRP1	genetic	8058037
UBP14_YEAST	UBP14	genetic	15451116
UBP6_YEAST	UBP6	genetic	15451116
UBP4_YEAST	DOA4	genetic	15451116
SHR3_YEAST	SHR3	physical	16093310
ERD2_YEAST	ERD2	physical	16093310
PHO88_YEAST	PHO88	physical	16093310
ELO2_YEAST	ELO2	physical	16093310
SPC3_YEAST	SPC3	physical	16093310
ARO1_YEAST	ARO1	genetic	21623372
ADK_YEAST	ADO1	genetic	21623372
TRPE_YEAST	TRP2	genetic	21623372
ALLA_YEAST	DAL3	genetic	21623372
AROC_YEAST	ARO2	genetic	21623372
SOL4_YEAST	SOL4	genetic	21623372
SER33_YEAST	SER33	genetic	21623372
SERC_YEAST	SER1	genetic	21623372
TRPD_YEAST	TRP4	genetic	21623372
GSHR_YEAST	GLR1	genetic	21623372
CSG2_YEAST	CSG2	genetic	21623372
SPEE_YEAST	SPE3	genetic	21623372
FCY2_YEAST	FCY2	genetic	21623372
GPX3_YEAST	HYR1	genetic	21623372
PDX3_YEAST	PDX3	genetic	21623372
ATH1_YEAST	ATH1	genetic	21623372
THI21_YEAST	THI21	genetic	21623372
HMDH2_YEAST	HMG2	genetic	21623372
LEM3_YEAST	LEM3	genetic	23250744
PMA1_YEAST	PMA1	physical	23421703
RV167_YEAST	RVS167	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
TRPF_YEAST	TRP1	genetic	27708008
TPS2_YEAST	TPS2	genetic	27708008
ARO1_YEAST	ARO1	genetic	27708008
TRPD_YEAST	TRP4	genetic	27708008
TRPE_YEAST	TRP2	genetic	27708008
SODM_YEAST	SOD2	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
YJ24_YEAST	KCH1	genetic	27708008
TRPG_YEAST	TRP3	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.