KMO_YEAST - dbPTM
KMO_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KMO_YEAST
UniProt AC P38169
Protein Name Kynurenine 3-monooxygenase {ECO:0000255|HAMAP-Rule:MF_03018}
Gene Name BNA4 {ECO:0000255|HAMAP-Rule:MF_03018}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 460
Subcellular Localization Mitochondrion outer membrane .
Protein Description Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid..
Protein Sequence MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLKSINLAISARGIDALKSIDPDACEHILQDMIPMKGRMIHDLKGRQESQLYGLHGEAINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAIGEDLKTPHTEKYDFVIGCDGAYSATRSQMQRKVEMDFSQEYMNLRYIELYIPPTEEFKPNYGGNFAIAPDHLHIWPRHKFMLIALANSDGSFTSTFFGSKDQISDLITSKSRVREFLIENFPDIINIMDLDDAVKRFITYPKESLVCVNCKPYDVPGGKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDRSRAFTEYTQTRHKDLVSITELAKRNYKEMSHDVTSKRFLLRKKLDALFSIIMKDKWIPLYTMISFRSDISYSRALERAGKQTRILKFLESLTLGMLSIGGYKLFKFLTRERS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Oxidation-------MSESVAII
-------CCCCEEEE		10.1415665377
2Phosphorylation------MSESVAIIG
------CCCCEEEEH		38.2828889911
4Phosphorylation----MSESVAIIGAG
----CCCCEEEEHHH		15.0015665377
22PhosphorylationCLAALAFSKEGYNVT
HHHHHHHCCCCCCEE		24.9615665377
89UbiquitinationGRMIHDLKGRQESQL
CCCCCCCCCCCHHHH		59.0917644757
122UbiquitinationSLLDELEKSTTELKF
HHHHHHHHHCCCCCC		66.7717644757
207UbiquitinationIPPTEEFKPNYGGNF
CCCCHHCCCCCCCCC		35.3217644757
259UbiquitinationISDLITSKSRVREFL
HHHHHHCHHHHHHHH		33.3624961812
397PhosphorylationKKLDALFSIIMKDKW
HHHHHHHHHHHCCCC		16.4419795423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KMO_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KMO_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KMO_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DEP1_YEASTDEP1genetic
20093466
REI1_YEASTREI1genetic
20093466
BSD2_YEASTBSD2genetic
20093466
PER1_YEASTPER1genetic
20093466
YCZ1_YEASTYCR101Cgenetic
20093466
UBP1_YEASTUBP1genetic
20093466
PHO2_YEASTPHO2genetic
20093466
BUG1_YEASTBUG1genetic
20093466
RPN4_YEASTRPN4genetic
20093466
NHP10_YEASTNHP10genetic
20093466
ARO1_YEASTARO1genetic
20093466
WDR59_YEASTMTC5genetic
20093466
GNTK_YEASTYDR248Cgenetic
20093466
EAF1_YEASTEAF1genetic
20093466
TNA1_YEASTTNA1genetic
20093466
FYV4_YEASTFYV4genetic
20093466
IME1_YEASTIME1genetic
20093466
STE24_YEASTSTE24genetic
20093466
BAS1_YEASTBAS1genetic
20093466
NKP2_YEASTNKP2genetic
20093466
ROM2_YEASTROM2genetic
20093466
SWS2_YEASTSWS2genetic
20093466
MED9_YEASTCSE2genetic
20093466
VHS3_YEASTVHS3genetic
20093466
NPT1_YEASTNPT1genetic
20093466
TNA1_YEASTTNA1genetic
21623372
NPT1_YEASTNPT1genetic
21623372
ARO1_YEASTARO1genetic
21623372
ATPO_YEASTATP5genetic
21623372
SNF5_YEASTSNF5genetic
27708008
MRM2_YEASTMRM2genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
COX7_YEASTCOX7genetic
27708008
PET8_YEASTPET8genetic
27708008
REI1_YEASTREI1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
IMG2_YEASTIMG2genetic
27708008
SAC3_YEASTSAC3genetic
27708008
MED5_YEASTNUT1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
TNA1_YEASTTNA1genetic
27708008
YHK5_YEASTYHR045Wgenetic
27708008
VPS53_YEASTVPS53genetic
27708008
ELM1_YEASTELM1genetic
27708008
YRA2_YEASTYRA2genetic
27708008
PHO23_YEASTPHO23genetic
27708008
SUCA_YEASTLSC1genetic
27708008
NPT1_YEASTNPT1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KMO_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-22, AND MASSSPECTROMETRY.

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