dbPTM

ADH7_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ADH7_YEAST
UniProt AC	P25377
Protein Name	NADP-dependent alcohol dehydrogenase 7
Gene Name	ADH7
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	361
Subcellular Localization
Protein Description	NADP-dependent alcohol dehydrogenase with a broad substrate specificity..
Protein Sequence	MLYPEKFQGIGISNAKDWKHPKLVSFDPKPFGDHDVDVEIEACGICGSDFHIAVGNWGPVPENQILGHEIIGRVVKVGSKCHTGVKIGDRVGVGAQALACFECERCKSDNEQYCTNDHVLTMWTPYKDGYISQGGFASHVRLHEHFAIQIPENIPSPLAAPLLCGGITVFSPLLRNGCGPGKRVGIVGIGGIGHMGILLAKAMGAEVYAFSRGHSKREDSMKLGADHYIAMLEDKGWTEQYSNALDLLVVCSSSLSKVNFDSIVKIMKIGGSIVSIAAPEVNEKLVLKPLGLMGVSISSSAIGSRKEIEQLLKLVSEKNVKIWVEKLPISEEGVSHAFTRMESGDVKYRFTLVDYDKKFHK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
132	Phosphorylation	PYKDGYISQGGFASH CCCCCCCCCCCCCCC	17.81	-
316	Phosphorylation	EQLLKLVSEKNVKIW HHHHHHHHHCCCEEE	53.97	17287358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ADH7_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ADH7_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ADH7_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADH7_YEAST	ADH7	physical	18719252
HSP71_YEAST	SSA1	physical	22940862
ORC6_YEAST	ORC6	genetic	27708008
PAN1_YEAST	PAN1	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
MED11_YEAST	MED11	genetic	27708008
ROT1_YEAST	ROT1	genetic	27708008
ISL1_HUMAN	ISL1	physical	27107014
MAGAC_HUMAN	MAGEA12	physical	27107014
COIL_HUMAN	COIL	physical	27107014
PDE9A_HUMAN	PDE9A	physical	27107014
ATRIP_HUMAN	ATRIP	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ADH7_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, AND MASSSPECTROMETRY.	17287358 [Abstract]