| UniProt ID | SLA2_YEAST | |
|---|---|---|
| UniProt AC | P33338 | |
| Protein Name | Protein SLA2 | |
| Gene Name | SLA2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 968 | |
| Subcellular Localization |
Cell membrane Single-pass membrane protein . Cytoplasm, cytoskeleton, actin patch. Cytoplasm, cell cortex. Bud tip. |
|
| Protein Description | Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H(+)-ATPase on the cell surface.. | |
| Protein Sequence | MSRIDSDLQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEAIRDRDWIRSLGRVHSGGSSYSKLIREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVSVSDPDEGYETILDLMSLQDSLDEFSQIIFASIQSERRNTECKISALIPLIAESYGIYKFITSMLRAMHRQLNDAEGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKLPVDAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPTGATTGMMIPTATGAANAIFPQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQELFQQQLQKAQQDMMNMQLQQQNQHQNDLIALTNQYEKDQALLQQYDQRVQQLESEITTMDSTASKQLANKDEQLTALQDQLDVWERKYESLAKLYSQLRQEHLNLLPRFKKLQLKVNSAQESIQKKEQLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMTQDKMNPILDAILESGINTIQESVYNLDSPLSWSGPLTPPTFLLSLLESTSENATEFATSFNNLIVDGLAHGDQTEVIHCVSDFSTSMATLVTNSKAYAVTTLPQEQSDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEKLQELSLAIEPLLNIQSVKSNKETNPHSELVATADKIVKSSEHLRVDVPKPLLSLALMIIDAVVALVKAAIQCQNEIATTTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSLGNHVMGMIEDDHSTSQQQQPLDFTSEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHAYYNQDDD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Acetylation | RIDSDLQKALKKACS CCCHHHHHHHHHHCC | 64.08 | 24489116 | |
| 97 | Phosphorylation | RSLGRVHSGGSSYSK HHHCCCCCCCCHHHH | 41.83 | 30377154 | |
| 198 | Nitration | IAESYGIYKFITSML HHHHCCHHHHHHHHH | 8.76 | - | |
| 198 | Phosphorylation | IAESYGIYKFITSML HHHHCCHHHHHHHHH | 8.76 | 28132839 | |
| 225 | Ubiquitination | DAALQPLKERYELQH CHHHHHHHHHHHHHH | 46.99 | 23749301 | |
| 247 | Phosphorylation | ADCSSVKYLTTLVTI CCCCCCCEEEEEEEC | 13.71 | 22369663 | |
| 249 | Phosphorylation | CSSVKYLTTLVTIPK CCCCCEEEEEEECCC | 18.26 | 22369663 | |
| 250 | Phosphorylation | SSVKYLTTLVTIPKL CCCCEEEEEEECCCC | 19.35 | 22369663 | |
| 253 | Phosphorylation | KYLTTLVTIPKLPVD CEEEEEEECCCCCCC | 34.37 | 22369663 | |
| 274 | Acetylation | INDVDESKEIKFKKR ECCCCCCCCCCCCCC | 62.50 | 24489116 | |
| 274 | Ubiquitination | INDVDESKEIKFKKR ECCCCCCCCCCCCCC | 62.50 | 23749301 | |
| 277 | Ubiquitination | VDESKEIKFKKREPS CCCCCCCCCCCCCCC | 52.82 | 22817900 | |
| 279 | Ubiquitination | ESKEIKFKKREPSVT CCCCCCCCCCCCCCC | 46.01 | 22817900 | |
| 280 | Ubiquitination | SKEIKFKKREPSVTP CCCCCCCCCCCCCCC | 66.19 | 22817900 | |
| 284 | Phosphorylation | KFKKREPSVTPARTP CCCCCCCCCCCCCCC | 33.59 | 24930733 | |
| 286 | Phosphorylation | KKREPSVTPARTPAR CCCCCCCCCCCCCCC | 18.63 | 17563356 | |
| 290 | Phosphorylation | PSVTPARTPARTPTP CCCCCCCCCCCCCCC | 24.33 | 22369663 | |
| 294 | Phosphorylation | PARTPARTPTPTPPV CCCCCCCCCCCCCCC | 33.35 | 22369663 | |
| 296 | Phosphorylation | RTPARTPTPTPPVVA CCCCCCCCCCCCCCC | 38.90 | 22369663 | |
| 298 | Phosphorylation | PARTPTPTPPVVAEP CCCCCCCCCCCCCCC | 42.58 | 22369663 | |
| 308 | Phosphorylation | VVAEPAISPRPVSQR CCCCCCCCCCCCCCC | 19.57 | 22369663 | |
| 313 | Phosphorylation | AISPRPVSQRTTSTP CCCCCCCCCCCCCCC | 19.34 | 22369663 | |
| 535 | Acetylation | LQMAELVKDRDRARL HHHHHHHCHHHHHHH | 60.72 | 24489116 | |
| 547 | Phosphorylation | ARLELERSINNAEAD HHHHHHHHHCHHHHH | 21.94 | 28889911 | |
| 555 | Phosphorylation | INNAEADSAAATAAA HCHHHHHHHHHHHHH | 27.19 | 24961812 | |
| 559 | Phosphorylation | EADSAAATAAAETMT HHHHHHHHHHHHHHC | 16.47 | 27017623 | |
| 564 | Phosphorylation | AATAAAETMTQDKMN HHHHHHHHHCHHCCC | 22.31 | 26447709 | |
| 566 | Phosphorylation | TAAAETMTQDKMNPI HHHHHHHCHHCCCHH | 40.82 | 26447709 | |
| 681 | Acetylation | DQILTLVKRCAREAQ HHHHHHHHHHHHHHH | 44.89 | 24489116 | |
| 726 | Phosphorylation | QEKLQELSLAIEPLL HHHHHHHHHHHHHHH | 18.27 | 23749301 | |
| 737 | Phosphorylation | EPLLNIQSVKSNKET HHHHCCHHHHCCCCC | 27.93 | 23749301 | |
| 739 | Ubiquitination | LLNIQSVKSNKETNP HHCCHHHHCCCCCCC | 54.26 | 23749301 | |
| 740 | Phosphorylation | LNIQSVKSNKETNPH HCCHHHHCCCCCCCH | 51.48 | 23749301 | |
| 756 | Acetylation | ELVATADKIVKSSEH HHHHCHHHHHHCCCC | 47.11 | 24489116 | |
| 816 | Phosphorylation | YLKNSRWTEGLISAA ECCCCHHHHHHHHHH | 21.04 | 27017623 | |
| 821 | Phosphorylation | RWTEGLISAAKAVAG HHHHHHHHHHHHHHC | 27.50 | 27017623 | |
| 876 | Phosphorylation | VAASRVKTSIHSKAQ HHHHCCCHHHHHHHH | 30.01 | 19823750 | |
| 877 | Phosphorylation | AASRVKTSIHSKAQD HHHCCCHHHHHHHHH | 16.76 | 19823750 | |
| 880 | Phosphorylation | RVKTSIHSKAQDKLE CCCHHHHHHHHHHHH | 28.19 | 19823750 | |
| 913 | Phosphorylation | GMIEDDHSTSQQQQP HEECCCCCCCCCCCC | 36.43 | 21440633 | |
| 948 | Phosphorylation | LKLEQSLSNARKRLG HHHHHHHHHHHHHHH | 33.42 | 30377154 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLA2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLA2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284; THR-286; THR-290;THR-294; THR-296; THR-298; SER-308; SER-547 AND SER-555, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284; THR-286; THR-290;THR-294; THR-296 AND THR-298, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-294 AND SER-308, ANDMASS SPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-296 AND SER-308, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-290 AND THR-296, ANDMASS SPECTROMETRY. | |
