CCC1_YEAST - dbPTM
CCC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCC1_YEAST
UniProt AC P47818
Protein Name Protein CCC1
Gene Name CCC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 322
Subcellular Localization Golgi apparatus membrane . Vacuole membrane
Multi-pass membrane protein .
Protein Description Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals..
Protein Sequence MSIVALKNAVVTLIQKAKGSGGTSELGGSESTPLLRGSNSNSSRHDNLSSSSSDIIYGRNSAQDLENSPMSVGKDNRNGDNGSDNEKANLGFFQSVDPRVISDLIIGLSDGLTVPFALTAGLSSLGDAKLVITGGFAELISGAISMGLGGYLGAKSESDYYHAEVKKEKRKFYDNSNLINREIEDILLEINPNFSDETIVSFIKDLQRTPELMVDFIIRYGRGLDEPAENRELISAVTIGGGYLLGGLVPLVPYFFVSDVGTGLIYSIIVMVVTLFWFGYVKTKLSMGSGSSTSKKVTEGVEMVVVGGVAAGAAWFFVKLLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16UbiquitinationAVVTLIQKAKGSGGT
HHHHHHHHHCCCCCC		45.1022817900
18UbiquitinationVTLIQKAKGSGGTSE
HHHHHHHCCCCCCCC		61.7223749301
20PhosphorylationLIQKAKGSGGTSELG
HHHHHCCCCCCCCCC		33.0922369663
23PhosphorylationKAKGSGGTSELGGSE
HHCCCCCCCCCCCCC		23.6621440633
24PhosphorylationAKGSGGTSELGGSES
HCCCCCCCCCCCCCC		33.8122369663
29PhosphorylationGTSELGGSESTPLLR
CCCCCCCCCCCCCCC		26.9522369663
31PhosphorylationSELGGSESTPLLRGS
CCCCCCCCCCCCCCC		36.7022369663
32PhosphorylationELGGSESTPLLRGSN
CCCCCCCCCCCCCCC		17.5722369663
38PhosphorylationSTPLLRGSNSNSSRH
CCCCCCCCCCCCCCC		30.5630377154
40PhosphorylationPLLRGSNSNSSRHDN
CCCCCCCCCCCCCCC		39.5230377154
42PhosphorylationLRGSNSNSSRHDNLS
CCCCCCCCCCCCCCC		28.6823749301
43PhosphorylationRGSNSNSSRHDNLSS
CCCCCCCCCCCCCCC		37.5723749301
49PhosphorylationSSRHDNLSSSSSDII
CCCCCCCCCCHHHEE		34.1322369663
50PhosphorylationSRHDNLSSSSSDIIY
CCCCCCCCCHHHEEC		37.0922369663
51PhosphorylationRHDNLSSSSSDIIYG
CCCCCCCCHHHEECC		30.4122369663
52PhosphorylationHDNLSSSSSDIIYGR
CCCCCCCHHHEECCC		33.7022369663
53PhosphorylationDNLSSSSSDIIYGRN
CCCCCCHHHEECCCC		34.4722369663
57PhosphorylationSSSSDIIYGRNSAQD
CCHHHEECCCCCHHH		15.4622890988
61PhosphorylationDIIYGRNSAQDLENS
HEECCCCCHHHHCCC		26.4122369663
68PhosphorylationSAQDLENSPMSVGKD
CHHHHCCCCCCCCCC		16.7722369663
71PhosphorylationDLENSPMSVGKDNRN
HHCCCCCCCCCCCCC		30.9722369663
74UbiquitinationNSPMSVGKDNRNGDN
CCCCCCCCCCCCCCC		50.0723749301
83PhosphorylationNRNGDNGSDNEKANL
CCCCCCCCCCHHHCC		43.4417330950
87UbiquitinationDNGSDNEKANLGFFQ
CCCCCCHHHCCCCCC		49.1523749301
95PhosphorylationANLGFFQSVDPRVIS
HCCCCCCCCCHHHHH		24.2729136822
171UbiquitinationEVKKEKRKFYDNSNL
HHHHHHHHHCCCCCC		60.3823749301
176PhosphorylationKRKFYDNSNLINREI
HHHHCCCCCCCCHHH		30.0727214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FET4_YEASTFET4genetic
11390404
MRS3_YEASTMRS3genetic
15161905
MRS4_YEASTMRS4genetic
15161905
PCL1_YEASTPCL1genetic
16760462
RL23A_YEASTRPL23Agenetic
16760462
RL23B_YEASTRPL23Agenetic
16760462
COT1_YEASTCOT1genetic
18930916
FRA1_YEASTFRA1genetic
20139087
RIM2_YEASTRIM2genetic
20139087
RIM2_YEASTRIM2genetic
21115478
MRS3_YEASTMRS3genetic
21115478
MRS4_YEASTMRS4genetic
21115478
TSA1_YEASTTSA1genetic
21115478
TYW1_YEASTTYW1genetic
21917924
TYW2_YEASTTRM12genetic
21917924
VPS54_YEASTVPS54genetic
21987634
UBP4_YEASTDOA4genetic
21987634
RV167_YEASTRVS167genetic
21987634
GABAT_YEASTUGA1genetic
21987634
PEP12_YEASTPEP12genetic
21987634
ORM1_YEASTORM1genetic
22768841
ORM2_YEASTORM2genetic
22768841
HSP7Q_YEASTSSQ1genetic
22915593
FRDA_YEASTYFH1genetic
22915593
ISU1_YEASTISU1genetic
22915593
MMT1_YEASTMMT1genetic
24798331
MMT2_YEASTMMT2genetic
24798331
MRS3_YEASTMRS3genetic
24798331
MRS4_YEASTMRS4genetic
24798331
YP153_YEASTYPR153Wgenetic
27708008
ODO2_YEASTKGD2genetic
27708008
RAD51_YEASTRAD51genetic
27708008
HAC1_YEASTHAC1genetic
27708008
RAD54_YEASTRAD54genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
IRE1_YEASTIRE1genetic
27708008
TSA1_YEASTTSA1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
TSA1_YEASTTSA1genetic
29674565
CG13_YEASTCLN3genetic
29674565
BUD14_YEASTBUD14genetic
29674565
CSG2_YEASTCSG2genetic
29674565
ARL1_YEASTARL1genetic
29674565
HPC2_YEASTHPC2genetic
29674565
BUD3_YEASTBUD3genetic
29674565
SNT1_YEASTSNT1genetic
29674565
QRI7_YEASTQRI7genetic
29674565
KIN28_YEASTKIN28genetic
29674565
CYK3_YEASTCYK3genetic
29674565
DBF4_YEASTDBF4genetic
29674565
SECU_YEASTPDS1genetic
29674565
NBP2_YEASTNBP2genetic
29674565
SPT3_YEASTSPT3genetic
29674565
ERD1_YEASTERD1genetic
29674565
SDC1_YEASTSDC1genetic
29674565
PSP1_YEASTPSP1genetic
29674565
KRE28_YEASTKRE28genetic
29674565
RAD51_YEASTRAD51genetic
29674565
SPT2_YEASTSPT2genetic
29674565
MED5_YEASTNUT1genetic
29674565
RTF1_YEASTRTF1genetic
29674565
OPI1_YEASTOPI1genetic
29674565
KEL1_YEASTKEL1genetic
29674565
ATC7_YEASTNEO1genetic
29674565
AXL2_YEASTAXL2genetic
29674565
ASF1_YEASTASF1genetic
29674565
PBS2_YEASTPBS2genetic
29674565
CBF1_YEASTCBF1genetic
29674565
CDC11_YEASTCDC11genetic
29674565
BUD4_YEASTBUD4genetic
29674565
ELM1_YEASTELM1genetic
29674565
FEN1_YEASTRAD27genetic
29674565
SA190_YEASTSAP190genetic
29674565
SET3_YEASTSET3genetic
29674565
UTH1_YEASTUTH1genetic
29674565
CTF3_YEASTCTF3genetic
29674565
CDC73_YEASTCDC73genetic
29674565
RAD52_YEASTRAD52genetic
29674565
POB3_YEASTPOB3genetic
29674565
SUB1_YEASTSUB1genetic
29674565
MOT3_YEASTMOT3genetic
29674565
CIN4_YEASTCIN4genetic
29674565
SKY1_YEASTSKY1genetic
29674565
SCS7_YEASTSCS7genetic
29674565
LCB1_YEASTLCB1genetic
29674565
LSM7_YEASTLSM7genetic
29674565
TOP1_YEASTTOP1genetic
29674565
RGA1_YEASTRGA1genetic
29674565
LCB4_YEASTLCB4genetic
29674565
CTF19_YEASTCTF19genetic
29674565
SUR1_YEASTSUR1genetic
29674565
BEM3_YEASTBEM3genetic
29674565
SEC23_YEASTSEC23genetic
29674565
BRE1_YEASTBRE1genetic
29674565
VPS35_YEASTVPS35genetic
29674565
YKZ1_YEASTYKR011Cgenetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCC1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-49; SER-51;SER-52; SER-53; SER-68; SER-71 AND SER-83, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-51; SER-52;SER-53; SER-68; SER-71 AND SER-83, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-52, AND MASSSPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-32, AND MASSSPECTROMETRY.

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