AXL2_YEAST - dbPTM
AXL2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AXL2_YEAST
UniProt AC P38928
Protein Name Axial budding pattern protein 2
Gene Name AXL2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 823
Subcellular Localization Cell membrane
Single-pass type I membrane protein . In small buds, localizes to incipient bud sites, emerging buds and to the bud periphery. In large buds, localizes as a ring at the bud neck. Requires ERV14 to be efficiently delivered to the cell
Protein Description Required for haploid cells axial budding pattern. Acts as an anchor to help direct new growth components and/or polarity establishment components like the BUD5 GTP/GDP exchange factor to localize at the cortical axial budding site. Regulates septin organization in late G1 independently of its role in polarity-axis determination..
Protein Sequence MTQLQISLLLTATISLLHLVVATPYEAYPIGKQYPPVARVNESFTFQISNDTYKSSVDKTAQITYNCFDLPSWLSFDSSSRTFSGEPSSDLLSDANTTLYFNVILEGTDSADSTSLNNTYQFVVTNRPSISLSSDFNLLALLKNYGYTNGKNALKLDPNEVFNVTFDRSMFTNEESIVSYYGRSQLYNAPLPNWLFFDSGELKFTGTAPVINSAIAPETSYSFVIIATDIEGFSAVEVEFELVIGAHQLTTSIQNSLIINVTDTGNVSYDLPLNYVYLDDDPISSDKLGSINLLDAPDWVALDNATISGSVPDELLGKNSNPANFSVSIYDTYGDVIYFNFEVVSTTDLFAISSLPNINATRGEWFSYYFLPSQFTDYVNTNVSLEFTNSSQDHDWVKFQSSNLTLAGEVPKNFDKLSLGLKANQGSQSQELYFNIIGMDSKITHSNHSANATSTRSSHHSTSTSSYTSSTYTAKISSTSAAATSSAPAALPAANKTSSHNKKAVAIACGVAIPLGVILVALICFLIFWRRRRENPDDENLPHAISGPDLNNPANKPNQENATPLNNPFDDDASSYDDTSIARRLAALNTLKLDNHSATESDISSVDEKRDSLSGMNTYNDQFQSQSKEELLAKPPVQPPESPFFDPQNRSSSVYMDSEPAVNKSWRYTGNLSPVSDIVRDSYGSQKTVDTEKLFDLEAPEKEKRTSRDVTMSSLDPWNSNISPSPVRKSVTPSPYNVTKHRNRHLQNIQDSQSGKNGITPTTMSTSSSDDFVPVKDGENFCWVHSMEPDRRPSKKRLVDFSNKSNVNVGQVKDIHGRIPEML
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41N-linked_GlycosylationYPPVARVNESFTFQI
CCCCEEECCCEEEEE		33.37-
50N-linked_GlycosylationSFTFQISNDTYKSSV
CEEEEECCCCCCCCC		47.47-
96N-linked_GlycosylationSDLLSDANTTLYFNV
HHHHCCCCCEEEEEE		38.29-
117N-linked_GlycosylationSADSTSLNNTYQFVV
CCCCCCCCCEEEEEE		38.27-
163N-linked_GlycosylationLDPNEVFNVTFDRSM
CCCCCCEEEEEEHHH		36.77-
260N-linked_GlycosylationIQNSLIINVTDTGNV
EECCEEEEEECCCCE		24.52-
266N-linked_GlycosylationINVTDTGNVSYDLPL
EEEECCCCEEEEECC		22.96-
304N-linked_GlycosylationPDWVALDNATISGSV
CCEEEECCCEEECCC		39.57-
324N-linked_GlycosylationGKNSNPANFSVSIYD
CCCCCCCCEEEEEEE		30.86-
359N-linked_GlycosylationISSLPNINATRGEWF
ECCCCCCCCCCCCCE		41.73-
382N-linked_GlycosylationFTDYVNTNVSLEFTN
HHCCCCCCEEEEEEC		19.04-
389N-linked_GlycosylationNVSLEFTNSSQDHDW
CEEEEEECCCCCCCE		45.01-
403N-linked_GlycosylationWVKFQSSNLTLAGEV
EEEEECCCEEEEEEC		42.14-
416AcetylationEVPKNFDKLSLGLKA
ECCCCCCCEEEEEEC		35.5224489116
447N-linked_GlycosylationDSKITHSNHSANATS
CCCCCCCCCCCCCCC		26.06-
451N-linked_GlycosylationTHSNHSANATSTRSS
CCCCCCCCCCCCCCC		46.92-
495N-linked_GlycosylationPAALPAANKTSSHNK
CCCCCCCCCCCCCCH		50.69-
597PhosphorylationTLKLDNHSATESDIS
CCCCCCCCCCHHHCC		43.0423749301
599PhosphorylationKLDNHSATESDISSV
CCCCCCCCHHHCCCH		38.7523749301
601PhosphorylationDNHSATESDISSVDE
CCCCCCHHHCCCHHH		35.5723749301
604PhosphorylationSATESDISSVDEKRD
CCCHHHCCCHHHHHH		29.3323749301
605PhosphorylationATESDISSVDEKRDS
CCHHHCCCHHHHHHC		33.6423749301
609UbiquitinationDISSVDEKRDSLSGM
HCCCHHHHHHCCCCC		57.9823749301
612PhosphorylationSVDEKRDSLSGMNTY
CHHHHHHCCCCCCCC		28.5920377248
614PhosphorylationDEKRDSLSGMNTYND
HHHHHCCCCCCCCCH		39.6922369663
618PhosphorylationDSLSGMNTYNDQFQS
HCCCCCCCCCHHHHH		18.1429734811
619PhosphorylationSLSGMNTYNDQFQSQ
CCCCCCCCCHHHHHC		16.2528889911
625PhosphorylationTYNDQFQSQSKEELL
CCCHHHHHCCHHHHH		37.4020377248
627PhosphorylationNDQFQSQSKEELLAK
CHHHHHCCHHHHHCC		47.4820377248
634UbiquitinationSKEELLAKPPVQPPE
CHHHHHCCCCCCCCC		50.2323749301
642PhosphorylationPPVQPPESPFFDPQN
CCCCCCCCCCCCCCC		32.5524909858
651PhosphorylationFFDPQNRSSSVYMDS
CCCCCCCCCCEECCC		34.2220377248
652PhosphorylationFDPQNRSSSVYMDSE
CCCCCCCCCEECCCC		22.1528889911
653PhosphorylationDPQNRSSSVYMDSEP
CCCCCCCCEECCCCC		20.6524961812
655PhosphorylationQNRSSSVYMDSEPAV
CCCCCCEECCCCCCC		9.3520377248
664UbiquitinationDSEPAVNKSWRYTGN
CCCCCCCCCCCCCCC		44.8123749301
665PhosphorylationSEPAVNKSWRYTGNL
CCCCCCCCCCCCCCC		16.1623749301
668PhosphorylationAVNKSWRYTGNLSPV
CCCCCCCCCCCCCCH		16.8521440633
669PhosphorylationVNKSWRYTGNLSPVS
CCCCCCCCCCCCCHH		15.8328132839
673PhosphorylationWRYTGNLSPVSDIVR
CCCCCCCCCHHHHHH		27.5317330950
676PhosphorylationTGNLSPVSDIVRDSY
CCCCCCHHHHHHHCC		25.6317330950
682PhosphorylationVSDIVRDSYGSQKTV
HHHHHHHCCCCCCEE		22.3421440633
683PhosphorylationSDIVRDSYGSQKTVD
HHHHHHCCCCCCEEC		25.7019779198
685PhosphorylationIVRDSYGSQKTVDTE
HHHHCCCCCCEECHH		21.9221440633
687UbiquitinationRDSYGSQKTVDTEKL
HHCCCCCCEECHHHH		52.8123749301
688PhosphorylationDSYGSQKTVDTEKLF
HCCCCCCEECHHHHH		18.9023749301
691PhosphorylationGSQKTVDTEKLFDLE
CCCCEECHHHHHCCC		30.5921440633
693UbiquitinationQKTVDTEKLFDLEAP
CCEECHHHHHCCCCC		57.4523749301
706PhosphorylationAPEKEKRTSRDVTMS
CCHHHCCCCCCCCHH		38.9021440633
707PhosphorylationPEKEKRTSRDVTMSS
CHHHCCCCCCCCHHH		30.4320377248
711PhosphorylationKRTSRDVTMSSLDPW
CCCCCCCCHHHCCCC		18.6722369663
713PhosphorylationTSRDVTMSSLDPWNS
CCCCCCHHHCCCCCC		20.5522369663
714PhosphorylationSRDVTMSSLDPWNSN
CCCCCHHHCCCCCCC		26.4323749301
720PhosphorylationSSLDPWNSNISPSPV
HHCCCCCCCCCCCCC		31.5022369663
723PhosphorylationDPWNSNISPSPVRKS
CCCCCCCCCCCCCCC		24.4722369663
725PhosphorylationWNSNISPSPVRKSVT
CCCCCCCCCCCCCCC		29.2722369663
730PhosphorylationSPSPVRKSVTPSPYN
CCCCCCCCCCCCCCC		22.2122369663
732PhosphorylationSPVRKSVTPSPYNVT
CCCCCCCCCCCCCCH		25.7420377248
734PhosphorylationVRKSVTPSPYNVTKH
CCCCCCCCCCCCHHH		30.5620377248
736PhosphorylationKSVTPSPYNVTKHRN
CCCCCCCCCCHHHHH		26.9721440633
739PhosphorylationTPSPYNVTKHRNRHL
CCCCCCCHHHHHHHH		19.9324961812
752PhosphorylationHLQNIQDSQSGKNGI
HHHHHCCCCCCCCCC		15.1824909858
754PhosphorylationQNIQDSQSGKNGITP
HHHCCCCCCCCCCCC		56.5425533186
763PhosphorylationKNGITPTTMSTSSSD
CCCCCCCCEECCCCC		15.4421440633
765PhosphorylationGITPTTMSTSSSDDF
CCCCCCEECCCCCCE		24.0521440633
766PhosphorylationITPTTMSTSSSDDFV
CCCCCEECCCCCCEE		23.0821440633
767PhosphorylationTPTTMSTSSSDDFVP
CCCCEECCCCCCEEE		22.1220377248
768PhosphorylationPTTMSTSSSDDFVPV
CCCEECCCCCCEEEC		37.5620377248
769PhosphorylationTTMSTSSSDDFVPVK
CCEECCCCCCEEECC		40.7520377248
802PhosphorylationKKRLVDFSNKSNVNV
CCCEEECCCCCCCCH		38.5928889911
805PhosphorylationLVDFSNKSNVNVGQV
EEECCCCCCCCHHHH		50.7022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AXL2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AXL2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AXL2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BUD5_YEASTBUD5physical
11313501
CDC42_YEASTCDC42physical
17460121
BUD3_YEASTBUD3physical
17460121
BUD4_YEASTBUD4physical
17460121
GIN4_YEASTGIN4genetic
17460121
CLA4_YEASTCLA4genetic
17460121
TLG1_YEASTTLG1physical
16093310
TRK1_YEASTTRK1physical
16093310
AIM3_YEASTAIM3genetic
21035341
KPYK1_YEASTCDC19physical
22940862
ORC2_YEASTORC2genetic
27708008
CDK1_YEASTCDC28genetic
27708008
LCB2_YEASTLCB2genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
FIP1_YEASTFIP1genetic
27708008
RRS1_YEASTRRS1genetic
27708008
MYO2_YEASTMYO2genetic
27708008
TF2B_YEASTSUA7genetic
27708008
BUR1_YEASTSGV1genetic
27708008
VPS8_YEASTVPS8genetic
27708008
VMA21_YEASTVMA21genetic
27708008
RAS2_YEASTRAS2genetic
27708008
GLO4_YEASTGLO4genetic
27708008
CKS1_YEASTCKS1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
CDC7_YEASTCDC7genetic
27708008
RPB1_YEASTRPO21genetic
27708008
CDC20_YEASTCDC20genetic
27708008
CDC11_YEASTCDC11genetic
27708008
TIM23_YEASTTIM23genetic
27708008
HRR25_YEASTHRR25genetic
27708008
SLA1_YEASTSLA1genetic
27708008
EDE1_YEASTEDE1genetic
27708008
BOB1_YEASTBOI1genetic
27708008
RTG3_YEASTRTG3genetic
27708008
RKM3_YEASTRKM3genetic
27708008
TPS1_YEASTTPS1genetic
27708008
SEC66_YEASTSEC66genetic
27708008
GFD2_YEASTGFD2genetic
27708008
RV161_YEASTRVS161genetic
27708008
RIM1_YEASTRIM1genetic
27708008
CRD1_YEASTCRD1genetic
27708008
YFF4_YEASTYFL054Cgenetic
27708008
CUE3_YEASTCUE3genetic
27708008
AAKG_YEASTSNF4genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
HXKB_YEASTHXK2genetic
27708008
ELP2_YEASTELP2genetic
27708008
MED20_YEASTSRB2genetic
27708008
UBA4_YEASTUBA4genetic
27708008
KEL1_YEASTKEL1genetic
27708008
MDV1_YEASTMDV1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
ELM1_YEASTELM1genetic
27708008
YKH5_YEASTYKL075Cgenetic
27708008
KTI12_YEASTKTI12genetic
27708008
DBP7_YEASTDBP7genetic
27708008
POM33_YEASTPOM33genetic
27708008
SRN2_YEASTSRN2genetic
27708008
ACE2_YEASTACE2genetic
27708008
PFD6_YEASTYKE2genetic
27708008
COA4_YEASTCOA4genetic
27708008
ARV1_YEASTARV1genetic
27708008
UBC12_YEASTUBC12genetic
27708008
CHS5_YEASTCHS5genetic
27708008
ROM2_YEASTROM2genetic
27708008
ELP1_YEASTIKI3genetic
27708008
GAS1_YEASTGAS1genetic
27708008
ELP6_YEASTELP6genetic
27708008
CTU2_YEASTNCS2genetic
27708008
MDM12_YEASTMDM12genetic
27708008
NOP12_YEASTNOP12genetic
27708008
IRA2_YEASTIRA2genetic
27708008
RRP6_YEASTRRP6genetic
27708008
YAP4_YEASTCIN5genetic
27708008
HIR2_YEASTHIR2genetic
27708008
WHI2_YEASTWHI2genetic
27708008
SFL1_YEASTSFL1genetic
27708008
RUD3_YEASTRUD3genetic
27708008
MKK1_YEASTMKK1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
TBP6_YEASTYTA6genetic
27708008
ELP3_YEASTELP3genetic
27708008
ELP4_YEASTELP4genetic
27708008
BECN1_YEASTVPS30genetic
27708008
ATG5_YEASTATG5genetic
27708008
RGA1_YEASTRGA1genetic
27001830
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AXL2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-673 AND SER-676, ANDMASS SPECTROMETRY.

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