PCL1_YEAST - dbPTM
PCL1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCL1_YEAST
UniProt AC P24867
Protein Name PHO85 cyclin-1 {ECO:0000305|PubMed:7973730}
Gene Name PCL1 {ECO:0000303|PubMed:7973730}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 279
Subcellular Localization Cytoplasm . Nucleus . Localizes to the incipient bud site.
Protein Description G1/S-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 phosphorylates LCB4, which is required for its ubiquitination and degradation. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit..
Protein Sequence MCEYSKALHILLKSPVTDDIIKFLTDTTLRVVPSSNYPTPPGSPGEKHLTRLPSLMTFITRLVRYTNVYTPTLLTAACYLNKLKRILPRDATGLPSTIHRIFLACLILSAKFHNDSSPLNKHWARYTDGLFTLEDINLMERQLLQLLNWDLRVNTEDLILDLQPLLEPIKQDLARSSDQRKRINMMMSMNRRTCAGTSPIRSNNRFKLYEKQRNVSIASDLSSATLVDSCNDLRRLKDVTNIANNTVANTNYVRTVEKWNDNVNRQSWDLEQIMSQHGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MCEYSKALHILLK
--CCCHHHHHHHHHH		54.8117644757
13UbiquitinationKALHILLKSPVTDDI
HHHHHHHHCCCCHHH		49.6317644757
22UbiquitinationPVTDDIIKFLTDTTL
CCCHHHHHHHHCCCE		34.3517644757
39PhosphorylationVPSSNYPTPPGSPGE
CCCCCCCCCCCCCCH		31.5828152593
43PhosphorylationNYPTPPGSPGEKHLT
CCCCCCCCCCHHHHH		35.1928152593
47UbiquitinationPPGSPGEKHLTRLPS
CCCCCCHHHHHHHHH		50.2423749301
82UbiquitinationTAACYLNKLKRILPR
HHHHHHHHHHHHCCC		53.4423264631
96PhosphorylationRDATGLPSTIHRIFL
CCCCCCCHHHHHHHH		45.0628889911
111UbiquitinationACLILSAKFHNDSSP
HHHHHHHHHCCCCCC		43.7217644757
121UbiquitinationNDSSPLNKHWARYTD
CCCCCCHHHHHHHCC		48.4823264631
170UbiquitinationQPLLEPIKQDLARSS
HHHHHHHHHHHHCCH		48.7717644757
197PhosphorylationNRRTCAGTSPIRSNN
CCCCCCCCCCCCCCC		16.8925704821
198PhosphorylationRRTCAGTSPIRSNNR
CCCCCCCCCCCCCCC		19.8823749301
207UbiquitinationIRSNNRFKLYEKQRN
CCCCCCCHHEHHHHC		47.0922817900
211UbiquitinationNRFKLYEKQRNVSIA
CCCHHEHHHHCCCHH		40.7922817900
237UbiquitinationCNDLRRLKDVTNIAN
HHHHHHHHHHHHHCC		48.6323749301
250PhosphorylationANNTVANTNYVRTVE
CCCCCCCCCCCEEHH		20.4223749301
252PhosphorylationNTVANTNYVRTVEKW
CCCCCCCCCEEHHHH		6.8323749301
258UbiquitinationNYVRTVEKWNDNVNR
CCCEEHHHHCCCCCC		47.1423749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
39TPhosphorylationKinasePHO85P17157
Uniprot
43SPhosphorylationKinasePHO85P17157
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCL1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCL1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PHO4_YEASTPHO4physical
7973730
PHO85_YEASTPHO85physical
7973730
NCPR_YEASTNCP1physical
15082539
HMS1_YEASTHMS1physical
15082539
GPN1_YEASTNPA3physical
15082539
BEM2_YEASTBEM2genetic
11139490
DMA1_YEASTDMA1physical
16330754
ISR1_YEASTISR1physical
16330754
PAN3_YEASTPAN3physical
16330754
KCC4_YEASTKCC4physical
16330754
ROM2_YEASTROM2physical
16330754
SHS1_YEASTSHS1physical
16330754
SFB3_YEASTSFB3physical
16330754
RV167_YEASTRVS167physical
16330754
AME1_YEASTAME1physical
16330754
BCP1_YEASTBCP1physical
16330754
KPYK1_YEASTCDC19physical
16330754
KSP1_YEASTKSP1physical
16330754
NOP3_YEASTNPL3physical
16330754
PAM1_YEASTPAM1physical
16330754
REG1_YEASTREG1physical
16330754
EIF3A_YEASTRPG1physical
16330754
SA185_YEASTSAP185physical
16330754
SSD1_YEASTSSD1physical
16330754
UGPA1_YEASTUGP1physical
16330754
IGD1_YEASTIGD1physical
16330754
FPK1_YEASTFPK1physical
16330754
GTS1_YEASTGTS1physical
16330754
MNN11_YEASTMNN11genetic
19269370
WHI5_YEASTWHI5genetic
19823668
BCK1_YEASTBCK1genetic
19458192
BEM2_YEASTBEM2genetic
19458192
CDC42_YEASTCDC42genetic
19458192
BNI1_YEASTBNI1genetic
19458192
BNI4_YEASTBNI4genetic
19458192
PPA5_YEASTPHO5genetic
19458192
PCL2_YEASTPCL2genetic
19458192
BEM1_YEASTBEM1genetic
20093466
CYK3_YEASTCYK3genetic
20093466
PT122_YEASTPET122genetic
20093466
MED5_YEASTNUT1genetic
20093466
ASK10_YEASTASK10genetic
20093466
RL24B_YEASTRPL24Bgenetic
20093466
CBT1_YEASTCBT1genetic
20093466
COX12_YEASTCOX12genetic
20093466
SWI6_YEASTSWI6genetic
20093466
LIPB_YEASTLIP2genetic
20093466
RSC2_YEASTRSC2genetic
20093466
SSO2_YEASTSSO2genetic
20093466
NST1_YEASTNST1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
CY1_YEASTCYT1genetic
20093466
MNE1_YEASTMNE1genetic
20093466
HAP5_YEASTHAP5genetic
20093466
YP066_YEASTRGL1genetic
20093466
MED1_YEASTMED1genetic
20093466
QCR2_YEASTQCR2genetic
20093466
PCL2_YEASTPCL2genetic
20382759
PHO85_YEASTPHO85physical
20489023
DMA1_YEASTDMA1physical
23264631
HSP71_YEASTSSA1physical
23217712
CYK3_YEASTCYK3genetic
27708008
BCS1_YEASTBCS1genetic
27708008
MED5_YEASTNUT1genetic
27708008
CBT1_YEASTCBT1genetic
27708008
SWI6_YEASTSWI6genetic
27708008
SSO2_YEASTSSO2genetic
27708008
NGL2_YEASTNGL2genetic
27708008
SWS2_YEASTSWS2genetic
27708008
NST1_YEASTNST1genetic
27708008
CY1_YEASTCYT1genetic
27708008
MNE1_YEASTMNE1genetic
27708008
HAP5_YEASTHAP5genetic
27708008
YP066_YEASTRGL1genetic
27708008
MED1_YEASTMED1genetic
27708008
QCR2_YEASTQCR2genetic
27708008
TYE7_YEASTTYE7genetic
28122947
BAS1_YEASTBAS1genetic
28122947
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCL1_YEAST

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Related Literatures of Post-Translational Modification

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