| UniProt ID | SFB3_YEAST | |
|---|---|---|
| UniProt AC | P38810 | |
| Protein Name | SED5-binding protein 3 | |
| Gene Name | SFB3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 929 | |
| Subcellular Localization | Cytoplasm. Golgi apparatus membrane. Endoplasmic reticulum membrane. | |
| Protein Description | Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.. | |
| Protein Sequence | MSQQNILAASVSALSLDESTVHTGGASSKKSRRPHRAYHNFSSGTVPTLGNSPYTTPQLNQQDGFQQPQAFTPKQFGGFNNGSGSVMSTPVMVSQERFGASEASSPYGQSMLDMTAPQPTSHIVPTQRFEDQAQYLQRSFETCRDSVPPLPTTQFYCVDQGSCDPHLMSLSMYNIPESEHLRAATKLPLGLTIQPFSTLTPNDAEVPTIPLPMDGTPLRCRRCRAYANPKFQFTYDSSVICNICRVKMQVPGEHFAPMGPNGQRSDLNEKSELLHGTVDFLVPSIYNAIQEKELLPLHYVFLIDVSLLANENGSSLAMVEGVRSCIEYISDFQPNCEVAIIVYDNKLRFFNLRPDLDNAQEYIVSELDDVFLPFYNGLFVKPGNSMKIINDTLIKISGYISTDKYSHVPQVCYGSALQAAKLALDTVTGGQGGKIICSLNSLPTIGNGNLSLKRDNAHIAHVKCDNGFYKKLASDFLKSYISLDLYVTNAGFIDMATVGHPVEMTSGILKYYPHFQQETDAFTLVNDMVTNVSNIVGYQALLKVRCSTGLSVEQYYCDSSDNTDHDPIIPVLTRDTTLDVLLKYDSKIKTGTDVHFQTALLYTDIDGVRKVRSINTSGAVSNNIREIFKFINQNPVMRIMIKDVIKTLGDCDFVKIRRLIDDKMVEILTQYRGLVSSNSSTQLILPDSIKTLPAYMLAFEKSELMKPNAQSTRGNERIYDLLKYDSLNSAQLCYKLYPQIVPFHVLLEETDLTFYDANDKLLQINSSSINNLSVRASHSNFINGGCYLIFQGDTIYLWFNENTNRMLLQDLLSVDESLPVSQISLFSGTLPETGTSINQKASNVIKNWQQVVNKSSLPLVLLRPNVDQYYSNVMSQLLCEDKTVNRIESYDNYLVIMHKKIQEKLQKDDFIKVSTAATHENIHQKFVQF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSQQNILAA ------CCHHHHHHH | 40.24 | 22369663 | |
| 10 | Phosphorylation | QQNILAASVSALSLD HHHHHHHHHHEEECC | 15.82 | 22369663 | |
| 12 | Phosphorylation | NILAASVSALSLDES HHHHHHHHEEECCCC | 22.46 | 22369663 | |
| 15 | Phosphorylation | AASVSALSLDESTVH HHHHHEEECCCCCCC | 33.23 | 22369663 | |
| 19 | Phosphorylation | SALSLDESTVHTGGA HEEECCCCCCCCCCC | 35.08 | 22369663 | |
| 20 | Phosphorylation | ALSLDESTVHTGGAS EEECCCCCCCCCCCC | 17.79 | 22369663 | |
| 23 | Phosphorylation | LDESTVHTGGASSKK CCCCCCCCCCCCCCC | 32.73 | 22369663 | |
| 27 | Phosphorylation | TVHTGGASSKKSRRP CCCCCCCCCCCCCCC | 46.06 | 22369663 | |
| 28 | Phosphorylation | VHTGGASSKKSRRPH CCCCCCCCCCCCCCC | 43.50 | 22369663 | |
| 38 | Phosphorylation | SRRPHRAYHNFSSGT CCCCCCCCCCCCCCC | 9.39 | 30377154 | |
| 42 | Phosphorylation | HRAYHNFSSGTVPTL CCCCCCCCCCCCCCC | 32.92 | 23749301 | |
| 43 | Phosphorylation | RAYHNFSSGTVPTLG CCCCCCCCCCCCCCC | 34.05 | 19779198 | |
| 45 | Phosphorylation | YHNFSSGTVPTLGNS CCCCCCCCCCCCCCC | 25.84 | 19779198 | |
| 48 | Phosphorylation | FSSGTVPTLGNSPYT CCCCCCCCCCCCCCC | 42.85 | 19779198 | |
| 52 | Phosphorylation | TVPTLGNSPYTTPQL CCCCCCCCCCCCCCC | 19.93 | 21082442 | |
| 54 | Phosphorylation | PTLGNSPYTTPQLNQ CCCCCCCCCCCCCCC | 24.06 | 28152593 | |
| 55 | Phosphorylation | TLGNSPYTTPQLNQQ CCCCCCCCCCCCCCC | 35.07 | 28152593 | |
| 56 | Phosphorylation | LGNSPYTTPQLNQQD CCCCCCCCCCCCCCC | 11.82 | 28152593 | |
| 72 | Phosphorylation | FQQPQAFTPKQFGGF CCCCCCCCCCCCCCC | 32.37 | 28152593 | |
| 83 | Phosphorylation | FGGFNNGSGSVMSTP CCCCCCCCCCCCCCC | 29.98 | 22369663 | |
| 85 | Phosphorylation | GFNNGSGSVMSTPVM CCCCCCCCCCCCCEE | 19.15 | 22369663 | |
| 88 | Phosphorylation | NGSGSVMSTPVMVSQ CCCCCCCCCCEEEEH | 27.66 | 22369663 | |
| 89 | Phosphorylation | GSGSVMSTPVMVSQE CCCCCCCCCEEEEHH | 11.21 | 22369663 | |
| 94 | Phosphorylation | MSTPVMVSQERFGAS CCCCEEEEHHHHCCC | 14.29 | 22369663 | |
| 101 | Phosphorylation | SQERFGASEASSPYG EHHHHCCCCCCCCCC | 33.79 | 22369663 | |
| 104 | Phosphorylation | RFGASEASSPYGQSM HHCCCCCCCCCCCCC | 28.00 | 22369663 | |
| 105 | Phosphorylation | FGASEASSPYGQSML HCCCCCCCCCCCCCC | 29.23 | 22369663 | |
| 107 | Phosphorylation | ASEASSPYGQSMLDM CCCCCCCCCCCCCCC | 29.73 | 22369663 | |
| 110 | Phosphorylation | ASSPYGQSMLDMTAP CCCCCCCCCCCCCCC | 19.56 | 22369663 | |
| 115 | Phosphorylation | GQSMLDMTAPQPTSH CCCCCCCCCCCCCCC | 34.55 | 22369663 | |
| 120 | Phosphorylation | DMTAPQPTSHIVPTQ CCCCCCCCCCCCCCC | 27.91 | 22369663 | |
| 121 | Phosphorylation | MTAPQPTSHIVPTQR CCCCCCCCCCCCCCC | 20.21 | 22369663 | |
| 126 | Phosphorylation | PTSHIVPTQRFEDQA CCCCCCCCCCHHHHH | 22.83 | 22369663 | |
| 216 | Phosphorylation | IPLPMDGTPLRCRRC CCCCCCCCCCCCCCC | 18.19 | 28889911 | |
| 328 | Phosphorylation | GVRSCIEYISDFQPN HHHHHHHHHHCCCCC | 5.94 | 27017623 | |
| 330 | Phosphorylation | RSCIEYISDFQPNCE HHHHHHHHCCCCCCE | 31.32 | 27017623 | |
| 392 | Phosphorylation | SMKIINDTLIKISGY CEEEECCCEEEEECE | 26.37 | 30377154 | |
| 451 | Phosphorylation | TIGNGNLSLKRDNAH CCCCCCEEECCCCEE | 35.53 | 15665377 | |
| 629 | Acetylation | NNIREIFKFINQNPV CCHHHHHHHHHCCCH | 51.50 | 24489116 | |
| 663 | Acetylation | IRRLIDDKMVEILTQ EEECCCHHHHHHHHH | 40.89 | 24489116 | |
| 676 | Phosphorylation | TQYRGLVSSNSSTQL HHHCCCCCCCCCCEE | 28.92 | 22369663 | |
| 677 | Phosphorylation | QYRGLVSSNSSTQLI HHCCCCCCCCCCEEE | 33.00 | 22369663 | |
| 679 | Phosphorylation | RGLVSSNSSTQLILP CCCCCCCCCCEEECC | 36.39 | 22369663 | |
| 680 | Phosphorylation | GLVSSNSSTQLILPD CCCCCCCCCEEECCC | 25.15 | 22369663 | |
| 681 | Phosphorylation | LVSSNSSTQLILPDS CCCCCCCCEEECCCH | 27.50 | 22369663 | |
| 688 | Phosphorylation | TQLILPDSIKTLPAY CEEECCCHHHHHHHH | 24.84 | 22369663 | |
| 706 | Ubiquitination | FEKSELMKPNAQSTR HCCHHHCCCCCCCCC | 47.98 | 23749301 | |
| 846 | Ubiquitination | QKASNVIKNWQQVVN HHHHHHHHHHHHHHC | 48.10 | 24961812 | |
| 890 | Phosphorylation | TVNRIESYDNYLVIM CCCEEHHCCCEEEEE | 8.74 | 27017623 | |
| 893 | Phosphorylation | RIESYDNYLVIMHKK EEHHCCCEEEEEHHH | 10.23 | 27017623 | |
| 907 | Acetylation | KIQEKLQKDDFIKVS HHHHHHCCCCCEEEC | 70.47 | 24489116 | |
| 925 | Acetylation | THENIHQKFVQF--- CCCCHHHHHHCC--- | 33.08 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SFB3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SFB3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SFB3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-52; SER-83;SER-85; SER-94; SER-101; SER-105; SER-110 AND THR-216, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, AND MASSSPECTROMETRY. | |
