SDHF4_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDHF4_YEAST
• UniProt AC: P38345
• Protein Name: Succinate dehydrogenase assembly factor 4, mitochondrial {ECO:0000303|PubMed:24954416}
• Gene Name: SDH8 {ECO:0000303|PubMed:24954416}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 138
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit SDH1 in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDH2 into the SDH catalytic dimer..
• Protein Sequence: MLCAIKSTGYRYPRTGALNLLRGRPFNMATRKITTERIPGPPKLPREEQEEFERLQRIATSQEAIDQYNAQATGDRTKESLNSPLLTKNDIGSFSPEFSKTIPEFEGDVNPKTGEVGGPKQDPLRHGDYSFNGRVTDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Acetylation	ERIPGPPKLPREEQE CCCCCCCCCCHHHHH		24489116
60	Phosphorylation	ERLQRIATSQEAIDQ HHHHHHHHCHHHHHH		28889911
61	Phosphorylation	RLQRIATSQEAIDQY HHHHHHHCHHHHHHH		30377154
77	Phosphorylation	AQATGDRTKESLNSP HHHHCCCCHHHHCCC		21126336
80	Phosphorylation	TGDRTKESLNSPLLT HCCCCHHHHCCCCCC		21126336
83	Phosphorylation	RTKESLNSPLLTKND CCHHHHCCCCCCCCC		24909858
87	Phosphorylation	SLNSPLLTKNDIGSF HHCCCCCCCCCCCCC		28889911
88	Acetylation	LNSPLLTKNDIGSFS HCCCCCCCCCCCCCC		24489116
93	Phosphorylation	LTKNDIGSFSPEFSK CCCCCCCCCCHHHHC		28132839
95	Phosphorylation	KNDIGSFSPEFSKTI CCCCCCCCHHHHCCC		21551504
99	Phosphorylation	GSFSPEFSKTIPEFE CCCCHHHHCCCCCCC		28889911
100	Acetylation	SFSPEFSKTIPEFEG CCCHHHHCCCCCCCC		24489116
130	Phosphorylation	PLRHGDYSFNGRVTD CCCCCCCCCCCCCCC		28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDHF4_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDHF4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDHF4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FUMH_YEAST	FUM1	genetic	27708008
RS8A_YEAST	RPS8A	genetic	27708008
RS8B_YEAST	RPS8A	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
SAC3_YEAST	SAC3	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
YOR1_YEAST	YOR1	genetic	27708008
IF4A_YEAST	TIF2	genetic	27708008
ACE2_YEAST	ACE2	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008
COQ7_YEAST	CAT5	genetic	27708008
PDE2_YEAST	PDE2	genetic	27708008
UBA3_YEAST	UBA3	genetic	27708008
SDHA_YEAST	SDH1	physical	24954416
AP1_YEAST	YAP1	genetic	24954416
SDHA_YEAST	SDH1	genetic	24954416

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.