KTR3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KTR3_YEAST
• UniProt AC: P38130
• Protein Name: Probable mannosyltransferase KTR3
• Gene Name: KTR3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 404
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage..
• Protein Sequence: MSVHHKKKLMPKSALLIRKYQKGIRSSFIGLIIVLSFLFFMSGSRSPEVPIAQGTSVSRVASKDYLMPFTDKSQGVIHPVDDGKKEKGVMVTLARNSDLWNLVKSIRHVEDRFNNRYHYDWVFLNDQPFSDEFKRVTSALVSGKAKYGTIPKDHWSIPSWIDTEKFDEKRLAMGKLDIPYGSSVPYRHMCRFQSGFIWRHPLLEEYEWFWRVDTDITLFCDIQYDIFKFLKVNNKKYGFILSVSEYERTIPTLWETTKKFIKKNPKFLHKNNLMKFISNDDGDTYNMCHFWTNFEIGSLDFFRSDAYREYFDYLDSSGGFFYERWGDAPVHSIAASLFLDKSEIHFFDGLGFHHPDFTSCPIEQKIRLQNKCICEPSKDVTWTPDYFCTRKYFSAGNYKLPPGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	HKKKLMPKSALLIRK CCCCCCCHHHHHHHH	34.10	23749301
63	Acetylation	SVSRVASKDYLMPFT CCCEECCCCEECCCC	40.43	24489116
72	Ubiquitination	YLMPFTDKSQGVIHP EECCCCCCCCCCEEE	41.44	17644757
84	Ubiquitination	IHPVDDGKKEKGVMV EEECCCCCCCCCEEE	65.83	17644757
85	Ubiquitination	HPVDDGKKEKGVMVT EECCCCCCCCCEEEE	70.91	17644757
87	Ubiquitination	VDDGKKEKGVMVTLA CCCCCCCCCEEEEEE	66.73	17644757
104	Acetylation	SDLWNLVKSIRHVED HHHHHHHHHHHHHHH	43.25	24489116
137	Phosphorylation	SDEFKRVTSALVSGK CHHHHHHHHHHHCCC	16.59	19823750
138	Phosphorylation	DEFKRVTSALVSGKA HHHHHHHHHHHCCCC	19.42	19823750
142	Phosphorylation	RVTSALVSGKAKYGT HHHHHHHCCCCCCCC	35.11	19823750
175	Acetylation	EKRLAMGKLDIPYGS HHHHHCCCCCCCCCC	29.87	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KTR3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KTR3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KTR3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL4A_YEAST	RPL4A	physical	16429126
SVP26_YEAST	SVP26	physical	16107716
GOSR1_YEAST	GOS1	physical	16107716
GST1_YEAST	GTT1	physical	18719252
AAD4_YEAST	AAD4	genetic	20093466
RL41A_YEAST	RPL41A	genetic	20093466
RL41B_YEAST	RPL41A	genetic	20093466
YD180_YEAST	YDL180W	genetic	20093466
RS29B_YEAST	RPS29B	genetic	20093466
MTU1_YEAST	SLM3	genetic	20093466
SLX5_YEAST	SLX5	genetic	20093466
NHP10_YEAST	NHP10	genetic	20093466
GNTK_YEAST	YDR248C	genetic	20093466
RPOM_YEAST	RPO41	genetic	20093466
CHO2_YEAST	CHO2	genetic	20093466
VPS51_YEAST	VPS51	genetic	20093466
BUD21_YEAST	BUD21	genetic	20093466
FUMH_YEAST	FUM1	genetic	20093466
TMEDA_YEAST	ERV25	physical	20236934
SC61A_YEAST	SEC61	physical	20236934
SAM37_YEAST	SAM37	genetic	14764870
RTN1_YEAST	RTN1	genetic	23891562
ENT3_YEAST	ENT3	genetic	23891562
SRO7_YEAST	SRO7	genetic	23891562
TPM1_YEAST	TPM1	genetic	23891562
SVP26_YEAST	SVP26	physical	24585773
ERV46_YEAST	ERV46	physical	24585773
ERV41_YEAST	ERV41	physical	24585773
SVP26_YEAST	SVP26	physical	19574229
ARO1_YEAST	ARO1	genetic	27708008
NHP10_YEAST	NHP10	genetic	27708008
MTU1_YEAST	SLM3	genetic	27708008
RS29B_YEAST	RPS29B	genetic	27708008
YD180_YEAST	YDL180W	genetic	27708008
AAD4_YEAST	AAD4	genetic	27708008
GNTK_YEAST	YDR248C	genetic	27708008
PMP3_YEAST	PMP3	genetic	27708008
XRN1_YEAST	XRN1	genetic	27708008
BUD21_YEAST	BUD21	genetic	27708008
FUMH_YEAST	FUM1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.