dbPTM

HER1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HER1_YEAST
UniProt AC	Q12276
Protein Name	HMG2-induced ER-remodeling protein 1
Gene Name	HER1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1246
Subcellular Localization	Cytoplasm .
Protein Description	Required for HMG2-induced endoplasmic reticulum-remodeling..
Protein Sequence	MSSKLKYTDIDVPLDWLYKGKRRNRTKSAASTRTSEATTTSVKKTATLPSTAAVPTKTIASPQRPLSGQNVNNELSNSKPAVSAEKVSQQGQVPTRRTRSHSVSYGLLQKKNNNDDTTDSPKISRIRTAQDQPVKETKSSTLAEPIVSKKGRSRSSSISTSLNERSKKSLFGSLFGRRPSTTPSHVVERPLSSQNDHKKSTELPPIDTRQSKISTPTSTPTTASSKPSSSGGNRHSDGSLTSKLLSIPHNILETSSTNFNAHHHIQSHHSSGREQDSPHSESSDLPPILEKETTQKQLQKVSKVNLKRVTIAVQEFNSDPPQQLPSRKPKRGNVLIPEDMISAPPLISLGITNSSDQSSFQSNISPSYSKDSKEYKLALENFKKAAKEAEKHQKDAYYVAERMAQEVANYKARQLKTSPLTGATNSAADSATDQESSSLDARASKLHIDKPINVGAHPFETHQDDNIKYSSHLEQTLDVAYTRCCHLREILPIPSTLRQVKGKTAPLQTLKFLNPKPTLVDILSFCDFIAITPIHNIIFDNVSLTHDMFKIVICSLVTSPVVEKLGLRNVVINEQSWKLLCKFLLQNKTLIKLDISQTKARTDLNDSNYRDQMDWELFCEVLRNREGRPLEELLLNGLRFDKMSFSHFKNILLTFAQMNPKNPIRLGMANVEFSTECFDFLFNWMSEYNVQGVDLAYNNLESLAKRMIKKLARLPYKHLEYFTLNSTNITSVDDMSYILKYLSRLPSIKFLDLSNLPQLFPGILTSGYKYFPQFPQLKRIHFDFDDLSIKETTMLVSILAKCETLSHVSLIGQSPMPDASKISDSTDEPDKSKDEKKEQIVFMRNTLWASLYAFVRDSHNLVSLDVDYDQVPDEIQSRIALCLMHNMKRIMDSSFKLDELTVQDDLIFDGSLITETAEEVLKRLNDKSLLQNDVGKKYLLKKYFEKMEKVHHNVQNTIDSMFEKRKSGELPLQEKENLLRLLLLEKNLSNILDIFASMPNIADVVPFSKADNSFPNIGDSTVSANYNDGIRPSLKHLDSDRLINDVSIPENDSSIRPHLMATDSGRIIDVTTGKALLFKSSSNTSLAGKRQEEEEGELHKWGVFVQHQSSRHNSGLPSSANSSRISGSLTPDSSVAGGKKGESSRTSGTRPKILPKIPTGAELRDAIIKAKGIDSVDDLIKNVTSEKVGLESLYGDELNSRSPSNDSLQESQQKAPLQRPLVEDETVTKKYDKLLNDLSNVRHSKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	KRRNRTKSAASTRTS CCCCCCCCCCCCCCC	28.58	17287358
31	Phosphorylation	NRTKSAASTRTSEAT CCCCCCCCCCCCCCC	20.38	24961812
32	Phosphorylation	RTKSAASTRTSEATT CCCCCCCCCCCCCCC	32.99	24961812
34	Phosphorylation	KSAASTRTSEATTTS CCCCCCCCCCCCCCC	30.89	24961812
35	Phosphorylation	SAASTRTSEATTTSV CCCCCCCCCCCCCCC	23.18	24961812
38	Phosphorylation	STRTSEATTTSVKKT CCCCCCCCCCCCEEE	26.93	27717283
39	Phosphorylation	TRTSEATTTSVKKTA CCCCCCCCCCCEEEC	24.91	27717283
40	Phosphorylation	RTSEATTTSVKKTAT CCCCCCCCCCEEECC	27.45	27717283
41	Phosphorylation	TSEATTTSVKKTATL CCCCCCCCCEEECCC	29.82	23749301
45	Phosphorylation	TTTSVKKTATLPSTA CCCCCEEECCCCCCC	21.11	28889911
56	Phosphorylation	PSTAAVPTKTIASPQ CCCCCCCCCCCCCCC	33.93	28889911
58	Phosphorylation	TAAVPTKTIASPQRP CCCCCCCCCCCCCCC	25.01	28889911
61	Phosphorylation	VPTKTIASPQRPLSG CCCCCCCCCCCCCCC	20.09	25533186
67	Phosphorylation	ASPQRPLSGQNVNNE CCCCCCCCCCCCCHH	40.80	21440633
76	Phosphorylation	QNVNNELSNSKPAVS CCCCHHHCCCCCCCC	32.64	29688323
98	Phosphorylation	GQVPTRRTRSHSVSY CCCCCCCCCCCCHHH	32.98	17287358
100	Phosphorylation	VPTRRTRSHSVSYGL CCCCCCCCCCHHHHC	21.36	22890988
102	Phosphorylation	TRRTRSHSVSYGLLQ CCCCCCCCHHHHCEE	17.63	17330950
104	Phosphorylation	RTRSHSVSYGLLQKK CCCCCCHHHHCEECC	19.25	22890988
120	Phosphorylation	NNDDTTDSPKISRIR CCCCCCCCHHHHHHH	26.46	23749301
124	Phosphorylation	TTDSPKISRIRTAQD CCCCHHHHHHHCCCC	27.99	28889911
128	Phosphorylation	PKISRIRTAQDQPVK HHHHHHHCCCCCCCC	26.71	25533186
137	Phosphorylation	QDQPVKETKSSTLAE CCCCCCCCCCCCCCH	30.43	24930733
153	Phosphorylation	IVSKKGRSRSSSIST CCCCCCCCCCCCCCH	45.22	19684113
155	Phosphorylation	SKKGRSRSSSISTSL CCCCCCCCCCCCHHC	29.68	22890988
156	Phosphorylation	KKGRSRSSSISTSLN CCCCCCCCCCCHHCC	30.49	22890988
157	Phosphorylation	KGRSRSSSISTSLNE CCCCCCCCCCHHCCH	23.08	17330950
159	Phosphorylation	RSRSSSISTSLNERS CCCCCCCCHHCCHHH	17.56	22890988
160	Phosphorylation	SRSSSISTSLNERSK CCCCCCCHHCCHHHH	35.25	22890988
161	Phosphorylation	RSSSISTSLNERSKK CCCCCCHHCCHHHHH	23.54	22890988
173	Phosphorylation	SKKSLFGSLFGRRPS HHHHHHHHHHCCCCC	17.12	24961812
180	Phosphorylation	SLFGRRPSTTPSHVV HHHCCCCCCCCCHHH	43.00	28889911
181	Phosphorylation	LFGRRPSTTPSHVVE HHCCCCCCCCCHHHC	45.46	24961812
182	Phosphorylation	FGRRPSTTPSHVVER HCCCCCCCCCHHHCC	27.42	24961812
214	Phosphorylation	DTRQSKISTPTSTPT CCCCCCCCCCCCCCC	31.88	20377248
215	Phosphorylation	TRQSKISTPTSTPTT CCCCCCCCCCCCCCC	33.78	22369663
217	Phosphorylation	QSKISTPTSTPTTAS CCCCCCCCCCCCCCC	45.37	22369663
218	Phosphorylation	SKISTPTSTPTTASS CCCCCCCCCCCCCCC	33.33	20377248
219	Phosphorylation	KISTPTSTPTTASSK CCCCCCCCCCCCCCC	27.42	22369663
221	Phosphorylation	STPTSTPTTASSKPS CCCCCCCCCCCCCCC	34.77	22369663
222	Phosphorylation	TPTSTPTTASSKPSS CCCCCCCCCCCCCCC	26.25	22369663
224	Phosphorylation	TSTPTTASSKPSSSG CCCCCCCCCCCCCCC	36.48	20377248
225	Phosphorylation	STPTTASSKPSSSGG CCCCCCCCCCCCCCC	46.23	20377248
228	Phosphorylation	TTASSKPSSSGGNRH CCCCCCCCCCCCCCC	40.65	20377248
229	Phosphorylation	TASSKPSSSGGNRHS CCCCCCCCCCCCCCC	41.34	20377248
230	Phosphorylation	ASSKPSSSGGNRHSD CCCCCCCCCCCCCCC	55.87	20377248
239	Phosphorylation	GNRHSDGSLTSKLLS CCCCCCCCHHHHHHC	33.20	30377154
277	Phosphorylation	SSGREQDSPHSESSD CCCCCCCCCCCCCCC	24.98	22369663
280	Phosphorylation	REQDSPHSESSDLPP CCCCCCCCCCCCCCC	42.42	22369663
282	Phosphorylation	QDSPHSESSDLPPIL CCCCCCCCCCCCCCC	31.97	22369663
283	Phosphorylation	DSPHSESSDLPPILE CCCCCCCCCCCCCCC	38.83	22369663
410	Phosphorylation	MAQEVANYKARQLKT HHHHHHHHHCHHCCC	9.04	21126336
418	Phosphorylation	KARQLKTSPLTGATN HCHHCCCCCCCCCCC	19.14	23749301
424	Phosphorylation	TSPLTGATNSAADSA CCCCCCCCCHHHHCC	30.93	19779198
430	Phosphorylation	ATNSAADSATDQESS CCCHHHHCCCHHHCH	28.48	28889911
432	Phosphorylation	NSAADSATDQESSSL CHHHHCCCHHHCHHH	42.01	19779198
436	Phosphorylation	DSATDQESSSLDARA HCCCHHHCHHHHHHH	21.42	23749301
437	Phosphorylation	SATDQESSSLDARAS CCCHHHCHHHHHHHH	33.88	21440633
438	Phosphorylation	ATDQESSSLDARASK CCHHHCHHHHHHHHH	39.28	20377248
589	Phosphorylation	KFLLQNKTLIKLDIS HHHHCCCCEEEEECC	41.06	28889911
716	Phosphorylation	KKLARLPYKHLEYFT HHHHCCCCCCCEEEE	18.68	27017623
723	Phosphorylation	YKHLEYFTLNSTNIT CCCCEEEEECCCCCC	24.91	27017623
730	Phosphorylation	TLNSTNITSVDDMSY EECCCCCCCHHHHHH	25.43	27017623
731	Phosphorylation	LNSTNITSVDDMSYI ECCCCCCCHHHHHHH	21.54	27017623
736	Phosphorylation	ITSVDDMSYILKYLS CCCHHHHHHHHHHHH	18.93	27017623
823	Phosphorylation	MPDASKISDSTDEPD CCCHHHCCCCCCCCC	29.28	24961812
825	Phosphorylation	DASKISDSTDEPDKS CHHHCCCCCCCCCCC	30.85	24961812
893	Phosphorylation	NMKRIMDSSFKLDEL HHHHHHHCCCCCCCC	21.94	28889911
894	Phosphorylation	MKRIMDSSFKLDELT HHHHHHCCCCCCCCE	23.33	28889911
928	Phosphorylation	LKRLNDKSLLQNDVG HHHCCCHHHHCCHHH	36.86	25704821
967	Phosphorylation	SMFEKRKSGELPLQE HHHHHHHCCCCCHHH	41.34	21440633
1013	Phosphorylation	PFSKADNSFPNIGDS CCCCCCCCCCCCCCC	42.50	22369663
1020	Phosphorylation	SFPNIGDSTVSANYN CCCCCCCCCEECCCC	26.04	22369663
1021	Phosphorylation	FPNIGDSTVSANYND CCCCCCCCEECCCCC	24.18	22369663
1023	Phosphorylation	NIGDSTVSANYNDGI CCCCCCEECCCCCCC	15.75	22369663
1026	Phosphorylation	DSTVSANYNDGIRPS CCCEECCCCCCCCCH	17.85	22369663
1033	Phosphorylation	YNDGIRPSLKHLDSD CCCCCCCHHHCCCCC	39.95	22369663
1039	Phosphorylation	PSLKHLDSDRLINDV CHHHCCCCCCCCCCC	30.87	28889911
1053	Phosphorylation	VSIPENDSSIRPHLM CCCCCCCCCCCCCEE	38.97	19779198
1054	Phosphorylation	SIPENDSSIRPHLMA CCCCCCCCCCCCEEE	26.02	28889911
1064	Phosphorylation	PHLMATDSGRIIDVT CCEEECCCCCEEECC	26.14	28889911
1080	Phosphorylation	GKALLFKSSSNTSLA CCEEEEECCCCCCCC	31.50	19823750
1081	Phosphorylation	KALLFKSSSNTSLAG CEEEEECCCCCCCCC	28.35	19823750
1082	Phosphorylation	ALLFKSSSNTSLAGK EEEEECCCCCCCCCC	51.74	25521595
1084	Phosphorylation	LFKSSSNTSLAGKRQ EEECCCCCCCCCCCC	27.37	23749301
1085	Phosphorylation	FKSSSNTSLAGKRQE EECCCCCCCCCCCCH	22.07	24961812
1109	Phosphorylation	GVFVQHQSSRHNSGL EEEEEECHHCCCCCC	27.49	30377154
1114	Phosphorylation	HQSSRHNSGLPSSAN ECHHCCCCCCCCCCC	35.27	23749301
1118	Phosphorylation	RHNSGLPSSANSSRI CCCCCCCCCCCCCCC	47.31	28889911
1119	Phosphorylation	HNSGLPSSANSSRIS CCCCCCCCCCCCCCC	29.54	23749301
1122	Phosphorylation	GLPSSANSSRISGSL CCCCCCCCCCCCCCC	22.25	24961812
1123	Phosphorylation	LPSSANSSRISGSLT CCCCCCCCCCCCCCC	33.18	24961812
1126	Phosphorylation	SANSSRISGSLTPDS CCCCCCCCCCCCCCC	22.63	22369663
1128	Phosphorylation	NSSRISGSLTPDSSV CCCCCCCCCCCCCCC	23.44	22369663
1130	Phosphorylation	SRISGSLTPDSSVAG CCCCCCCCCCCCCCC	27.09	22369663
1133	Phosphorylation	SGSLTPDSSVAGGKK CCCCCCCCCCCCCCC	28.10	22369663
1134	Phosphorylation	GSLTPDSSVAGGKKG CCCCCCCCCCCCCCC	24.30	22369663
1175	Phosphorylation	IKAKGIDSVDDLIKN HHHCCCCCHHHHHHH	26.06	22369663
1192	Phosphorylation	SEKVGLESLYGDELN CCCCCHHHHHCHHCC	31.75	22369663
1194	Phosphorylation	KVGLESLYGDELNSR CCCHHHHHCHHCCCC	31.63	22369663
1200	Phosphorylation	LYGDELNSRSPSNDS HHCHHCCCCCCCCCC	46.92	22369663
1202	Phosphorylation	GDELNSRSPSNDSLQ CHHCCCCCCCCCCHH	32.28	22369663
1204	Phosphorylation	ELNSRSPSNDSLQES HCCCCCCCCCCHHHH	55.29	22369663
1207	Phosphorylation	SRSPSNDSLQESQQK CCCCCCCCHHHHHHH	35.88	22369663
1211	Phosphorylation	SNDSLQESQQKAPLQ CCCCHHHHHHHCCCC	25.58	22890988
1230	Acetylation	EDETVTKKYDKLLND CCHHHHHHHHHHHHH	49.68	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HER1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HER1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HER1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP12_YEAST	GLC7	physical	11805837
PTK2_YEAST	PTK2	genetic	19269370
HSP71_YEAST	SSA1	physical	19536198
SSB1_YEAST	SSB1	physical	19536198
AIM11_YEAST	AIM11	genetic	27708008
DEP1_YEAST	DEP1	genetic	27708008
IMG2_YEAST	IMG2	genetic	27708008
MTU1_YEAST	SLM3	genetic	27708008
RIM15_YEAST	RIM15	genetic	27708008
MTC3_YEAST	MTC3	genetic	27708008
YGY5_YEAST	YGL235W	genetic	27708008
PTH_YEAST	PTH1	genetic	27708008
RL22A_YEAST	RPL22A	genetic	27708008
ATP10_YEAST	ATP10	genetic	27708008
ATP18_YEAST	ATP18	genetic	27708008
BUL2_YEAST	BUL2	genetic	27708008
MSS18_YEAST	MSS18	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HER1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; SER-1013; THR-1130;TYR-1194 AND SER-1202, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; SER-282 ANDSER-1207, AND MASS SPECTROMETRY.	17563356 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102 AND SER-277, ANDMASS SPECTROMETRY.	17330950 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-98 AND THR-128, AND MASSSPECTROMETRY.	17287358 [Abstract]