| UniProt ID | FRE1_YEAST | |
|---|---|---|
| UniProt AC | P32791 | |
| Protein Name | Ferric/cupric reductase transmembrane component 1 {ECO:0000305} | |
| Gene Name | FRE1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 686 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake.. | |
| Protein Sequence | MVRTRVLFCLFISFFATVQSSATLISTSCISQAALYQFGCSSKSKSCYCKNINWLGSVTACAYENSKSNKTLDSALMKLASQCSSIKVYTLEDMKNIYLNASNYLRAPEKSDKKTVVSQPLMANETAYHYYYEENYGIHLNLMRSQWCAWGLVFFWVAVLTAATILNILKRVFGKNIMANSVKKSLIYPSVYKDYNERTFYLWKRLPFNFTTRGKGLVVLIFVILTILSLSFGHNIKLPHPYDRPRWRRSMAFVSRRADLMAIALFPVVYLFGIRNNPFIPITGLSFSTFNFYHKWSAYVCFMLAVVHSIVMTASGVKRGVFQSLVRKFYFRWGIVATILMSIIIFQSEKVFRNRGYEIFLLIHKAMNIMFIIAMYYHCHTLGWMGWIWSMAGILCFDRFCRIVRIIMNGGLKTATLSTTDDSNVIKISVKKPKFFKYQVGAFAYMYFLSPKSAWFYSFQSHPFTVLSERHRDPNNPDQLTMYVKANKGITRVLLSKVLSAPNHTVDCKIFLEGPYGVTVPHIAKLKRNLVGVAAGLGVAAIYPHFVECLRLPSTDQLQHKFYWIVNDLSHLKWFENELQWLKEKSCEVSVIYTGSSVEDTNSDESTKGFDDKEESEITVECLNKRPDLKELVRSEIKLSELENNNITFYSCGPATFNDDFRNAVVQGIDSSLKIDVELEEESFTW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Ubiquitination | KSKSCYCKNINWLGS CCCCEEECCCCCCCE | 34.09 | 17644757 | |
| 67 | Ubiquitination | ACAYENSKSNKTLDS EHHHCCCCCCCCHHH | 70.41 | 17644757 | |
| 68 | Phosphorylation | CAYENSKSNKTLDSA HHHCCCCCCCCHHHH | 43.30 | 28889911 | |
| 69 | N-linked_Glycosylation | AYENSKSNKTLDSAL HHCCCCCCCCHHHHH | 45.10 | - | |
| 71 | Phosphorylation | ENSKSNKTLDSALMK CCCCCCCCHHHHHHH | 39.79 | 28889911 | |
| 74 | Phosphorylation | KSNKTLDSALMKLAS CCCCCHHHHHHHHHH | 26.81 | 28889911 | |
| 100 | N-linked_Glycosylation | DMKNIYLNASNYLRA HHHHEEECCHHHCCC | 25.09 | - | |
| 124 | N-linked_Glycosylation | VSQPLMANETAYHYY ECCCCCCCCCHHHHH | 32.94 | - | |
| 500 | Phosphorylation | VLLSKVLSAPNHTVD HHHHHHHCCCCCCCE | 44.67 | 21440633 | |
| 509 | Ubiquitination | PNHTVDCKIFLEGPY CCCCCEEEEEEECCC | 31.84 | 17644757 | |
| 525 | Ubiquitination | VTVPHIAKLKRNLVG CCHHHHHHHHHHHHH | 54.67 | 17644757 | |
| 607 | Phosphorylation | DTNSDESTKGFDDKE CCCCCCCCCCCCCHH | 32.89 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FRE1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FRE1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FRE1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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