GPN1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPN1_YEAST
• UniProt AC: P47122
• Protein Name: GPN-loop GTPase 1 {ECO:0000303|PubMed:21532343}
• Gene Name: NPA3 {ECO:0000303|PubMed:15226434}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 385
• Subcellular Localization: Cytoplasm .
• Protein Description: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). [PubMed: 20855544]
• Protein Sequence: MSLSTIICIGMAGSGKTTFMQRLNSHLRAEKTPPYVINLDPAVLRVPYGANIDIRDSIKYKKVMENYQLGPNGAIVTSLNLFSTKIDQVIRLVEQKKDKFQNCIIDTPGQIECFVWSASGAIITESFASSFPTVIAYIVDTPRNSSPTTFMSNMLYACSILYKTKLPMIVVFNKTDVCKADFAKEWMTDFESFQAAIKEDQDLNGDNGLGSGYMSSLVNSMSLMLEEFYSQLDVVGVSSFTGDGFDEFMQCVDKKVDEYDQYYKQEREKALNLKKKKEEMRKQKSLNGLMKDLGLNEKSSAAASDNDSIDAISDLEEDANDGLVDRDEDEGVEREYTFPGEERTKGEVNENSAPDLQRRYQEAMQQVGKTASSETAENIAKYIRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLSTIICI ------CCCCEEEEE		30377154
4	Phosphorylation	----MSLSTIICIGM ----CCCCEEEEEEC		30377154
5	Phosphorylation	---MSLSTIICIGMA ---CCCCEEEEEECC		30377154
14	Phosphorylation	ICIGMAGSGKTTFMQ EEEECCCCCHHHHHH		30377154
18	Phosphorylation	MAGSGKTTFMQRLNS CCCCCHHHHHHHHHH		30377154
31	Ubiquitination	NSHLRAEKTPPYVIN HHHHHHCCCCCEEEE		23749301
31	Acetylation	NSHLRAEKTPPYVIN HHHHHHCCCCCEEEE		24489116
149	Phosphorylation	PRNSSPTTFMSNMLY CCCCCCCHHHHHHHH		19779198
162	Phosphorylation	LYACSILYKTKLPMI HHHHHHHHHCCCCEE		19779198
164	Phosphorylation	ACSILYKTKLPMIVV HHHHHHHCCCCEEEE		30377154
175	Phosphorylation	MIVVFNKTDVCKADF EEEEEECCCCCCHHH		30377154
179	Ubiquitination	FNKTDVCKADFAKEW EECCCCCCHHHHHHH		23749301
264	Ubiquitination	DEYDQYYKQEREKAL HHHHHHHHHHHHHHH		23749301
264	Acetylation	DEYDQYYKQEREKAL HHHHHHHHHHHHHHH		24489116
269	Ubiquitination	YYKQEREKALNLKKK HHHHHHHHHHCHHHH		23749301
285	Phosphorylation	EEMRKQKSLNGLMKD HHHHHHHHHHHHHHH		25752575
291	Acetylation	KSLNGLMKDLGLNEK HHHHHHHHHHCCCHH		24489116
299	Phosphorylation	DLGLNEKSSAAASDN HHCCCHHHHCCCCCC		29136822
300	Phosphorylation	LGLNEKSSAAASDND HCCCHHHHCCCCCCC		29136822
304	Phosphorylation	EKSSAAASDNDSIDA HHHHCCCCCCCCCCH		21082442
308	Phosphorylation	AAASDNDSIDAISDL CCCCCCCCCCHHHHH		21082442
313	Phosphorylation	NDSIDAISDLEEDAN CCCCCHHHHHHHHHC		22369663
337	Phosphorylation	EGVEREYTFPGEERT CCCEEEEECCCCCCC		27214570
344	Phosphorylation	TFPGEERTKGEVNEN ECCCCCCCCCCCCCC		29136822
345	Ubiquitination	FPGEERTKGEVNENS CCCCCCCCCCCCCCC		23749301
352	Phosphorylation	KGEVNENSAPDLQRR CCCCCCCCCHHHHHH		22369663
360	Phosphorylation	APDLQRRYQEAMQQV CHHHHHHHHHHHHHH		19823750
369	Ubiquitination	EAMQQVGKTASSETA HHHHHHCHHCCHHHH		23749301
370	Phosphorylation	AMQQVGKTASSETAE HHHHHCHHCCHHHHH		22369663
372	Phosphorylation	QQVGKTASSETAENI HHHCHHCCHHHHHHH		22369663
373	Phosphorylation	QVGKTASSETAENIA HHCHHCCHHHHHHHH		22369663
375	Phosphorylation	GKTASSETAENIAKY CHHCCHHHHHHHHHH		22369663
381	Acetylation	ETAENIAKYIRN--- HHHHHHHHHHHC---		24489116
381	Ubiquitination	ETAENIAKYIRN--- HHHHHHHHHHHC---		23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPN1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPN1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPN1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPN3_YEAST	GPN3	physical	10688190
GPN2_YEAST	GPN2	physical	10688190
RPB2_YEAST	RPB2	physical	18467557
PYRD_YEAST	URA1	physical	21844196
TPM1_YEAST	TPM1	physical	21844196
RPB1_YEAST	RPO21	physical	21844196
RPB2_YEAST	RPB2	physical	21844196
DEF1_YEAST	DEF1	physical	21844196
HSP7F_YEAST	SSE1	physical	21844196
HSP82_YEAST	HSP82	physical	21844196
HSP72_YEAST	SSA2	physical	21844196
SSB1_YEAST	SSB1	physical	21844196
HSP71_YEAST	SSA1	physical	21844196
GPN2_YEAST	GPN2	physical	21844196
RPB3_YEAST	RPB3	physical	21844196
RPAB1_YEAST	RPB5	physical	21844196
HSP77_YEAST	SSC1	physical	21844196
SSB2_YEAST	SSB2	physical	21844196
HSP60_YEAST	HSP60	physical	21844196
NU133_YEAST	NUP133	physical	21844196
XPO1_YEAST	CRM1	physical	21844196
GPN2_YEAST	GPN2	physical	23267056
GPN2_YEAST	GPN2	genetic	23267056
GPN1_YEAST	NPA3	physical	23324351
GPN2_YEAST	GPN2	physical	23324351
RPB1_YEAST	RPO21	physical	23324351
RPB2_YEAST	RPB2	physical	23324351
RPB3_YEAST	RPB3	physical	23324351
RPAB1_YEAST	RPB5	physical	23324351
RPA1_YEAST	RPA190	physical	23324351
RPA2_YEAST	RPA135	physical	23324351
RPB11_YEAST	RPB11	physical	23324351
RPC2_YEAST	RET1	physical	23324351
RPC1_YEAST	RPO31	physical	23324351
RPAC1_YEAST	RPC40	physical	23324351
RPAB3_YEAST	RPB8	physical	23324351
RTR1_YEAST	RTR1	physical	23324351
RBA50_YEAST	RBA50	physical	23324351
GPN3_YEAST	GPN3	physical	23324351
RPAB4_YEAST	RPC10	physical	23418395
RPB9_YEAST	RPB9	physical	23418395
RPB11_YEAST	RPB11	physical	23418395
RPAB5_YEAST	RPB10	physical	23418395
RPAB2_YEAST	RPO26	physical	23418395
RPB1_YEAST	RPO21	physical	23418395
RPB3_YEAST	RPB3	physical	23418395
RPAB1_YEAST	RPB5	physical	23418395
RPB2_YEAST	RPB2	physical	23418395
RPAB3_YEAST	RPB8	physical	23418395
T2FB_YEAST	TFG2	physical	23418395
SPT5_YEAST	SPT5	physical	23418395
RTR1_YEAST	RTR1	physical	23418395
GPN1_YEAST	NPA3	physical	26711263
RPB1_YEAST	RPO21	physical	26711263
RPB2_YEAST	RPB2	physical	26711263
RPAB3_YEAST	RPB8	physical	26711263
RPB9_YEAST	RPB9	physical	26711263
RPB11_YEAST	RPB11	physical	26711263
BIK1_YEAST	BIK1	genetic	27965115

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.