RPAB2_YEAST - dbPTM
RPAB2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPAB2_YEAST
UniProt AC P20435
Protein Name DNA-directed RNA polymerases I, II, and III subunit RPABC2
Gene Name RPO26
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 155
Subcellular Localization Cytoplasm . Nucleus .
Protein Description DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds..
Protein Sequence MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDYEEAFN
------CCHHHHHHC		49.2322369663
4Phosphorylation----MSDYEEAFNDG
----CCHHHHHHCCC		14.3619795423
24PhosphorylationDFDVEHFSDEETYEE
CCCCCCCCCCCCCCC		46.1222369663
28PhosphorylationEHFSDEETYEEKPQF
CCCCCCCCCCCCCCC		33.9022369663
29PhosphorylationHFSDEETYEEKPQFK
CCCCCCCCCCCCCCC		25.9322369663
46UbiquitinationETTDANGKTIVTGGN
CEECCCCCEEEECCC		34.5823749301
46AcetylationETTDANGKTIVTGGN
CEECCCCCEEEECCC		34.5824489116
82PhosphorylationPKDQRATTPYMTKYE
CCCHHCCCCCCCHHH		16.0728889911
102PhosphorylationGTRALQISMNAPVFV
CCEEEEEECCCCEEE		7.9428889911
123UbiquitinationDPLRIAMKELAEKKI
CHHHHHHHHHHHCCC		40.3223749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPAB2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPAB2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPAB2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPB1_YEASTRPO21physical
8887628
RPB3_YEASTRPB3physical
8887628
RPAB1_YEASTRPB5physical
8887628
RPB2_YEASTRPB2physical
8887628
RPA1_YEASTRPA190genetic
11486042
RPB1_YEASTRPO21genetic
8887628
RPB1_YEASTRPO21genetic
8923739
RPB1_YEASTRPO21genetic
2247052
PSB3_YEASTPUP3genetic
9278475
RPB2_YEASTRPB2physical
16554755
RPB4_YEASTRPB4physical
16429126
RPB7_YEASTRPB7physical
16429126
T2FA_YEASTTFG1physical
16429126
RPAC1_YEASTRPC40physical
16429126
RPC3_YEASTRPC82physical
16429126
RPB2_YEASTRPB2physical
16429126
RPB3_YEASTRPB3physical
16429126
RPB9_YEASTRPB9physical
16429126
RPB1_YEASTRPO21physical
16429126
T2FB_YEASTTFG2physical
16429126
IES2_YEASTIES2genetic
17314980
NEW1_YEASTNEW1genetic
17314980
MMS2_YEASTMMS2genetic
17314980
SLX8_YEASTSLX8genetic
17314980
AAKG_YEASTSNF4genetic
17314980
PLMT_YEASTOPI3genetic
17314980
COA4_YEASTCOA4genetic
17314980
ISW2_YEASTISW2genetic
17314980
SWC5_YEASTSWC5genetic
17314980
GET1_YEASTGET1genetic
17314980
SWI3_YEASTSWI3genetic
17314980
ARO1_YEASTARO1genetic
17314980
CDC26_YEASTCDC26genetic
17314980
ENT5_YEASTENT5genetic
17314980
CWC26_YEASTBUD13genetic
17314980
YP113_YEASTYPL113Cgenetic
17314980
SPT23_YEASTSPT23genetic
17314980
CG21_YEASTCLB1genetic
17314980
HTL1_YEASTHTL1genetic
17314980
ENV11_YEASTENV11genetic
17314980
HIR2_YEASTHIR2genetic
17314980
UBC8_YEASTUBC8genetic
17314980
MNN11_YEASTMNN11genetic
17314980
UME1_YEASTUME1genetic
17314980
ELOC_YEASTELC1genetic
17314980
XRN1_YEASTXRN1genetic
17314980
SET4_YEASTSET4genetic
17314980
XRN1_YEASTXRN1genetic
18676807
RPB4_YEASTRPB4genetic
18676807
RPB7_YEASTRPB7genetic
18676807
RPA43_YEASTRPA43physical
24153184
RPA14_YEASTRPA14physical
24153184
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPAB2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND THR-82, AND MASSSPECTROMETRY.

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