| UniProt ID | SWI3_YEAST | |
|---|---|---|
| UniProt AC | P32591 | |
| Protein Name | SWI/SNF complex subunit SWI3 | |
| Gene Name | SWI3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 825 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.. | |
| Protein Sequence | MENTLGEGSTVNASVDVDQHGNDNNSDSNANAAVAGVANTDTAGEESQQQDESLKDEATVPNTRDAESEAITVTAKQQPTMQANKLDSQETPSTEESRAQNVFGQDNEDSDNLFGETESSVSNNEANTPSIPTNPVDNENNKPAIKEDSTIQDSNGDVKNMEDVKIQKEEEPENNTVIEGVKEESQPDENTKEMDEVEEDDEDDDQPMISPDNSIFGDTKSESKQLGNTSSVANTPSEIPDAHKAEQEDIIEKTESVDKKVDSGEERNEQEREIMNDHSKSANPKKTTITRVEPETFEIPQAHEIVIPSYSKWFNLEKIHSIEVQSLPEFFTNRIPSKTPEVYMRYRNFMVNSYRLNPNEYFSVTTARRNVSGDAAALFRLHKFLTKWGLINYQVDSKLLPKNIEPPLTSQYSTRHDAPRGLFPFESYKPSVQLPDMAKLKKMMNTSDSESTLYKYLKESKRKYDEITHPPSTTDDENGDKNDNGGKMNNEVSTSTSMTGDANLLEEGETSRPLKKVKILEQIDENWSKEDLQKLLKGIQEFGADWYKVAKNVGNKSPEQCILRFLQLPIEDKFLYGDGNGKGDNDNGLGPLKYAPHLPFSKSENPVLSTIAFLVGLVNPKTVQSMTQRAIQSAESIKSQKEEISDQKPIEHIKEGSEIAISSLGYRSHIFATNEERQMNFLTNELIRLQMEKLDAKLNHLKKLEKFMELERKTLERQQENLLIQRLNFNQNSSKIVNVLSKCLNLISDSNINNSSVAEKEEIRSQIDHFKSMLSKPETLSIGKNPFNKPNIETGENHNGQSISNENDVKPISIEAPQFYRYWSA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 80 | Phosphorylation | VTAKQQPTMQANKLD EEECCCCCCCCCCCC | 19.99 | 22369663 | |
| 85 | Acetylation | QPTMQANKLDSQETP CCCCCCCCCCCCCCC | 57.60 | 24489116 | |
| 88 | Phosphorylation | MQANKLDSQETPSTE CCCCCCCCCCCCCHH | 40.11 | 22369663 | |
| 91 | Phosphorylation | NKLDSQETPSTEESR CCCCCCCCCCHHHHH | 18.20 | 22369663 | |
| 93 | Phosphorylation | LDSQETPSTEESRAQ CCCCCCCCHHHHHHH | 56.73 | 22369663 | |
| 94 | Phosphorylation | DSQETPSTEESRAQN CCCCCCCHHHHHHHH | 45.00 | 22369663 | |
| 97 | Phosphorylation | ETPSTEESRAQNVFG CCCCHHHHHHHHHCC | 27.04 | 22369663 | |
| 149 | Phosphorylation | KPAIKEDSTIQDSNG CCCCCCCCCCCCCCC | 28.62 | 28889911 | |
| 150 | Phosphorylation | PAIKEDSTIQDSNGD CCCCCCCCCCCCCCC | 34.67 | 30377154 | |
| 154 | Phosphorylation | EDSTIQDSNGDVKNM CCCCCCCCCCCCCCH | 26.74 | 28889911 | |
| 168 | Acetylation | MEDVKIQKEEEPENN HHHHCCCCCCCCCCC | 71.25 | 24489116 | |
| 176 | Phosphorylation | EEEPENNTVIEGVKE CCCCCCCCEEECCHH | 34.15 | 22369663 | |
| 185 | Phosphorylation | IEGVKEESQPDENTK EECCHHHCCCCCCCC | 48.37 | 22369663 | |
| 191 | Phosphorylation | ESQPDENTKEMDEVE HCCCCCCCCCCHHCC | 26.74 | 22369663 | |
| 210 | Phosphorylation | DDDQPMISPDNSIFG CCCCCCCCCCCCCCC | 21.68 | 20377248 | |
| 214 | Phosphorylation | PMISPDNSIFGDTKS CCCCCCCCCCCCCCC | 27.03 | 20377248 | |
| 219 | Phosphorylation | DNSIFGDTKSESKQL CCCCCCCCCCCHHCC | 36.53 | 19795423 | |
| 221 | Phosphorylation | SIFGDTKSESKQLGN CCCCCCCCCHHCCCC | 49.55 | 21551504 | |
| 229 | Phosphorylation | ESKQLGNTSSVANTP CHHCCCCCHHCCCCC | 22.15 | 22369663 | |
| 230 | Phosphorylation | SKQLGNTSSVANTPS HHCCCCCHHCCCCCC | 27.15 | 22369663 | |
| 231 | Phosphorylation | KQLGNTSSVANTPSE HCCCCCHHCCCCCCC | 24.18 | 22369663 | |
| 235 | Phosphorylation | NTSSVANTPSEIPDA CCHHCCCCCCCCCCH | 20.60 | 22369663 | |
| 237 | Phosphorylation | SSVANTPSEIPDAHK HHCCCCCCCCCCHHH | 46.23 | 22369663 | |
| 253 | Acetylation | EQEDIIEKTESVDKK HHHHHHHHHHHCCCC | 47.38 | 24489116 | |
| 263 | Phosphorylation | SVDKKVDSGEERNEQ HCCCCCCCCCHHHHH | 51.60 | 21440633 | |
| 353 | Phosphorylation | YRNFMVNSYRLNPNE HCCEEEEEEECCHHC | 10.54 | 28889911 | |
| 354 | Phosphorylation | RNFMVNSYRLNPNEY CCEEEEEEECCHHCC | 17.57 | 28889911 | |
| 409 | Phosphorylation | KNIEPPLTSQYSTRH CCCCCCCCCCCCCCC | 21.40 | 27214570 | |
| 428 | Phosphorylation | GLFPFESYKPSVQLP CCCCCCCCCCCCCCC | 21.52 | 21440633 | |
| 446 | Phosphorylation | KLKKMMNTSDSESTL HHHHHHCCCCCHHHH | 18.93 | 28889911 | |
| 451 | Phosphorylation | MNTSDSESTLYKYLK HCCCCCHHHHHHHHH | 27.88 | 28889911 | |
| 452 | Phosphorylation | NTSDSESTLYKYLKE CCCCCHHHHHHHHHH | 30.01 | 28889911 | |
| 464 | Phosphorylation | LKESKRKYDEITHPP HHHHHCCCCCCCCCC | 23.88 | 19823750 | |
| 468 | Phosphorylation | KRKYDEITHPPSTTD HCCCCCCCCCCCCCC | 26.70 | 19823750 | |
| 472 | Phosphorylation | DEITHPPSTTDDENG CCCCCCCCCCCCCCC | 48.68 | 19823750 | |
| 473 | Phosphorylation | EITHPPSTTDDENGD CCCCCCCCCCCCCCC | 39.76 | 19823750 | |
| 474 | Phosphorylation | ITHPPSTTDDENGDK CCCCCCCCCCCCCCC | 45.87 | 19823750 | |
| 510 | Phosphorylation | NLLEEGETSRPLKKV HHHCCCCCCCCHHHH | 40.67 | 27017623 | |
| 529 | Acetylation | QIDENWSKEDLQKLL HHCCCCCHHHHHHHH | 47.03 | 24489116 | |
| 548 | Acetylation | EFGADWYKVAKNVGN HHCCCHHHHHHHCCC | 31.31 | 24489116 | |
| 657 | Phosphorylation | IEHIKEGSEIAISSL CHHHHCCCEEEEECC | 27.24 | 27214570 | |
| 735 | Ubiquitination | NFNQNSSKIVNVLSK CCCCCHHHHHHHHHH | 50.96 | 23749301 | |
| 735 | Acetylation | NFNQNSSKIVNVLSK CCCCCHHHHHHHHHH | 50.96 | 24489116 | |
| 741 | Phosphorylation | SKIVNVLSKCLNLIS HHHHHHHHHHHHHHC | 19.62 | 15665377 | |
| 755 | Phosphorylation | SDSNINNSSVAEKEE CCCCCCCCCHHHHHH | 23.00 | 30377154 | |
| 756 | Phosphorylation | DSNINNSSVAEKEEI CCCCCCCCHHHHHHH | 27.72 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SWI3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SWI3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SWI3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88; THR-91; SER-185;SER-231 AND SER-657, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88; SER-231 AND THR-235,AND MASS SPECTROMETRY. | |
