FPK1_YEAST - dbPTM
FPK1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FPK1_YEAST
UniProt AC P53739
Protein Name Flippase kinase 1
Gene Name FPK1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 893
Subcellular Localization Cytoplasm . Cell membrane
Peripheral membrane protein .
Protein Description Flippase activator that phosphorylates DNF1 and DNF2 and which is involved in the generation of phospholipid asymmetry in membranes by the inward translocation of phospholipids and in the retrieval pathway from early endosomes to the trans-Golgi network (TGN). Phosphorylates also the N-terminal half of YPK1. Involved in pheromone-response..
Protein Sequence MAGHHHEHEQERDHEQEHEHDSLQRPTTGSERTRSISFSKLLTRSWKRNASSSNNMSVSSVNLYSDPENSRESDHNNSGSEGQSSRFSKLKSMFQSGNSSKNASAHNSSQSSLEGDSASSSSKLRYVKPMTSVANASPASPPLSPTIPETDVLQTPKMVHIDQHEHEREHSNCGSPIMLSSSSFSPTVARTGTGRRRSPSTPIMPSQNSNNSSSTSAIRPNNYRHHSGSQGFSSNNPFRERAGTVRSSNPYFAYQGLPTHAMSSHDLDEGFQPYANGSGIHFLSTPTSKTNSLTNTKNLSNLSLNEIKENEEVQEFNNEDFFFHDIPKDLSLKDTLNGSPSRGSSKSPTITQTFPSIIVGFDNEYEEDNNNDKHDEKEEQQTTTDNKTRNLSPTKQNGKATHPRIKIPLRRAASEPNGLQLASATSPTSSSARKTSGSSNINDKIPGQSVPPPNSFFPQEPSPKISDFPEPRRSRRLRTKSFSNKFQDIMVGPQSFEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLHLLGFIYRDLKPENILLHQSGHIMLSDFDLSIQAKDSKVPVVKGSAQSTLVDTKICSDGFRTNSFVGTEEYIAPEVIRGNGHTAAVDWWTLGILIYEMLFGFTPFKGDNTNETFTNILKNEVSFPNNNEISRTCKDLIKKLLTKNESKRLGCKMGAADVKKHPFFKKVQWSLLRNQEPPLIPVLSEDGYDFAKLSSNKKRQTSQDSHKHLDEQEKNMFEERVEYDDEVSEDDPFHDFNSMSLMEQDNNSMIYGNTNSYGKIAYTPNSNRSRSNSHRTFFKR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationPTTGSERTRSISFSK
CCCCCCCCCEEEHHH		25.3922369663
35PhosphorylationTGSERTRSISFSKLL
CCCCCCCEEEHHHHH		23.2122369663
37PhosphorylationSERTRSISFSKLLTR
CCCCCEEEHHHHHHH		25.3921440633
39PhosphorylationRTRSISFSKLLTRSW
CCCEEEHHHHHHHHH		18.6622369663
45PhosphorylationFSKLLTRSWKRNASS
HHHHHHHHHHHCCCC		31.5421440633
51PhosphorylationRSWKRNASSSNNMSV
HHHHHCCCCCCCCCC		37.5424961812
52PhosphorylationSWKRNASSSNNMSVS
HHHHCCCCCCCCCCE		34.3723749301
53PhosphorylationWKRNASSSNNMSVSS
HHHCCCCCCCCCCEE		29.7221440633
57PhosphorylationASSSNNMSVSSVNLY
CCCCCCCCCEEEEEE		22.4423749301
59PhosphorylationSSNNMSVSSVNLYSD
CCCCCCCEEEEEECC		22.6628889911
60PhosphorylationSNNMSVSSVNLYSDP
CCCCCCEEEEEECCC		16.9321440633
65PhosphorylationVSSVNLYSDPENSRE
CEEEEEECCCCCCCC		50.2727017623
70PhosphorylationLYSDPENSRESDHNN
EECCCCCCCCCCCCC		35.4423749301
73PhosphorylationDPENSRESDHNNSGS
CCCCCCCCCCCCCCC		42.9630377154
78PhosphorylationRESDHNNSGSEGQSS
CCCCCCCCCCCCCHH		49.3523749301
85PhosphorylationSGSEGQSSRFSKLKS
CCCCCCHHHHHHHHH		29.4723749301
92PhosphorylationSRFSKLKSMFQSGNS
HHHHHHHHHHHHCCC		34.9522369663
96PhosphorylationKLKSMFQSGNSSKNA
HHHHHHHHCCCCCCC		28.7722369663
99PhosphorylationSMFQSGNSSKNASAH
HHHHHCCCCCCCCCC		46.3322369663
100PhosphorylationMFQSGNSSKNASAHN
HHHHCCCCCCCCCCC		33.6522369663
104PhosphorylationGNSSKNASAHNSSQS
CCCCCCCCCCCCCCC		39.1822369663
108PhosphorylationKNASAHNSSQSSLEG
CCCCCCCCCCCCCCC		21.6422369663
109PhosphorylationNASAHNSSQSSLEGD
CCCCCCCCCCCCCCC		39.1222369663
111PhosphorylationSAHNSSQSSLEGDSA
CCCCCCCCCCCCCCC		38.5522369663
112PhosphorylationAHNSSQSSLEGDSAS
CCCCCCCCCCCCCCC		23.8522369663
117PhosphorylationQSSLEGDSASSSSKL
CCCCCCCCCCCCCCC		40.6922369663
119PhosphorylationSLEGDSASSSSKLRY
CCCCCCCCCCCCCEE		34.4022369663
120PhosphorylationLEGDSASSSSKLRYV
CCCCCCCCCCCCEEE		38.0422369663
121PhosphorylationEGDSASSSSKLRYVK
CCCCCCCCCCCEEEE		29.0622369663
122PhosphorylationGDSASSSSKLRYVKP
CCCCCCCCCCEEEEC		37.3422369663
126PhosphorylationSSSSKLRYVKPMTSV
CCCCCCEEEECCCCC		24.2222369663
131PhosphorylationLRYVKPMTSVANASP
CEEEECCCCCCCCCC		28.6922369663
132PhosphorylationRYVKPMTSVANASPA
EEEECCCCCCCCCCC		17.0022369663
137PhosphorylationMTSVANASPASPPLS
CCCCCCCCCCCCCCC		22.3222369663
140PhosphorylationVANASPASPPLSPTI
CCCCCCCCCCCCCCC		30.3622369663
144PhosphorylationSPASPPLSPTIPETD
CCCCCCCCCCCCCCC		26.2722369663
146PhosphorylationASPPLSPTIPETDVL
CCCCCCCCCCCCCCC		45.8722369663
150PhosphorylationLSPTIPETDVLQTPK
CCCCCCCCCCCCCCC		26.5022369663
155PhosphorylationPETDVLQTPKMVHID
CCCCCCCCCCEEEEC		22.2522369663
171PhosphorylationHEHEREHSNCGSPIM
CHHHHHHCCCCCCCE		29.1225704821
175PhosphorylationREHSNCGSPIMLSSS
HHHCCCCCCCEEECC		17.2925704821
180PhosphorylationCGSPIMLSSSSFSPT
CCCCCEEECCCCCCC		15.7028889911
181PhosphorylationGSPIMLSSSSFSPTV
CCCCEEECCCCCCCC		26.4919779198
183PhosphorylationPIMLSSSSFSPTVAR
CCEEECCCCCCCCCC		31.5219779198
185PhosphorylationMLSSSSFSPTVARTG
EEECCCCCCCCCCCC		22.9328889911
191PhosphorylationFSPTVARTGTGRRRS
CCCCCCCCCCCCCCC		29.3827017623
193PhosphorylationPTVARTGTGRRRSPS
CCCCCCCCCCCCCCC		27.2327017623
198PhosphorylationTGTGRRRSPSTPIMP
CCCCCCCCCCCCCCC		22.7622369663
200PhosphorylationTGRRRSPSTPIMPSQ
CCCCCCCCCCCCCCC		48.3222369663
201PhosphorylationGRRRSPSTPIMPSQN
CCCCCCCCCCCCCCC		21.8822369663
206PhosphorylationPSTPIMPSQNSNNSS
CCCCCCCCCCCCCCC		25.3122369663
209PhosphorylationPIMPSQNSNNSSSTS
CCCCCCCCCCCCCCC		29.7422369663
212PhosphorylationPSQNSNNSSSTSAIR
CCCCCCCCCCCCCCC		29.8922369663
213PhosphorylationSQNSNNSSSTSAIRP
CCCCCCCCCCCCCCC		39.5022369663
214PhosphorylationQNSNNSSSTSAIRPN
CCCCCCCCCCCCCCC		26.6322369663
215PhosphorylationNSNNSSSTSAIRPNN
CCCCCCCCCCCCCCC		24.9122369663
216PhosphorylationSNNSSSTSAIRPNNY
CCCCCCCCCCCCCCC		24.5222369663
227PhosphorylationPNNYRHHSGSQGFSS
CCCCCCCCCCCCCCC		33.7322369663
229PhosphorylationNYRHHSGSQGFSSNN
CCCCCCCCCCCCCCC		30.0922369663
263PhosphorylationGLPTHAMSSHDLDEG
CCCCCCCCCCCCCCC		25.8821440633
292PhosphorylationTPTSKTNSLTNTKNL
CCCCCCCCCCCCCCC		41.6325752575
294PhosphorylationTSKTNSLTNTKNLSN
CCCCCCCCCCCCCCC		40.4319823750
300PhosphorylationLTNTKNLSNLSLNEI
CCCCCCCCCCCHHHH		45.1522369663
303PhosphorylationTKNLSNLSLNEIKEN
CCCCCCCCHHHHHCC		33.1422369663
331PhosphorylationHDIPKDLSLKDTLNG
CCCCCCCCHHHHCCC		43.4321440633
335PhosphorylationKDLSLKDTLNGSPSR
CCCCHHHHCCCCCCC		22.1228889911
339PhosphorylationLKDTLNGSPSRGSSK
HHHHCCCCCCCCCCC		20.7319823750
341PhosphorylationDTLNGSPSRGSSKSP
HHCCCCCCCCCCCCC		51.4719823750
344PhosphorylationNGSPSRGSSKSPTIT
CCCCCCCCCCCCCCC		33.2228889911
345PhosphorylationGSPSRGSSKSPTITQ
CCCCCCCCCCCCCCC		39.7224961812
383PhosphorylationEKEEQQTTTDNKTRN
HHHHHHCCCCCCCCC		28.0227017623
384PhosphorylationKEEQQTTTDNKTRNL
HHHHHCCCCCCCCCC		40.7527017623
392PhosphorylationDNKTRNLSPTKQNGK
CCCCCCCCCCCCCCC		33.7919684113
394PhosphorylationKTRNLSPTKQNGKAT
CCCCCCCCCCCCCCC		41.7223749301
414PhosphorylationIPLRRAASEPNGLQL
CCCCHHCCCCCCEEE		53.2322369663
423PhosphorylationPNGLQLASATSPTSS
CCCEEEEECCCCCCC		40.4422369663
425PhosphorylationGLQLASATSPTSSSA
CEEEEECCCCCCCCC		32.5122369663
426PhosphorylationLQLASATSPTSSSAR
EEEEECCCCCCCCCC		26.3722369663
428PhosphorylationLASATSPTSSSARKT
EEECCCCCCCCCCCC		40.7922369663
429PhosphorylationASATSPTSSSARKTS
EECCCCCCCCCCCCC		26.1920377248
430PhosphorylationSATSPTSSSARKTSG
ECCCCCCCCCCCCCC		30.4123749301
431PhosphorylationATSPTSSSARKTSGS
CCCCCCCCCCCCCCC		31.6823749301
435PhosphorylationTSSSARKTSGSSNIN
CCCCCCCCCCCCCCC		32.5428889911
436PhosphorylationSSSARKTSGSSNIND
CCCCCCCCCCCCCCC		39.4528889911
438PhosphorylationSARKTSGSSNINDKI
CCCCCCCCCCCCCCC		21.7021440633
439PhosphorylationARKTSGSSNINDKIP
CCCCCCCCCCCCCCC		45.3028889911
449PhosphorylationNDKIPGQSVPPPNSF
CCCCCCCCCCCCCCC		42.3721126336
462PhosphorylationSFFPQEPSPKISDFP
CCCCCCCCCCHHCCC		37.7625521595
479PhosphorylationRRSRRLRTKSFSNKF
HHHCCCCCHHHHHHH		35.3221082442
481PhosphorylationSRRLRTKSFSNKFQD
HCCCCCHHHHHHHCH		33.0428152593
483PhosphorylationRLRTKSFSNKFQDIM
CCCCHHHHHHHCHHE		46.3228152593
525AcetylationTNRVYALKVLSKDEM
CCCEEEEEECCHHHH		32.7222865919
568PhosphorylationHSFQSEDYLYLCMEY
ECCCCCCHHHHHHHH		8.0029688323
570PhosphorylationFQSEDYLYLCMEYCM
CCCCCHHHHHHHHHH		7.5129688323
575PhosphorylationYLYLCMEYCMGGEFF
HHHHHHHHHHCHHHH		2.1029688323
587PhosphorylationEFFRALQTRKTKCIC
HHHHHHHHCCCCEEE		34.6829688323
657PhosphorylationKVPVVKGSAQSTLVD
CCCEEECCCCCCCCC		19.8819795423
660PhosphorylationVVKGSAQSTLVDTKI
EEECCCCCCCCCCEE		24.3519823750
661PhosphorylationVKGSAQSTLVDTKIC
EECCCCCCCCCCEEC		20.7919823750
669PhosphorylationLVDTKICSDGFRTNS
CCCCEECCCCCCCCC		44.2121440633
674PhosphorylationICSDGFRTNSFVGTE
ECCCCCCCCCCCCCC		32.7122369663
676PhosphorylationSDGFRTNSFVGTEEY
CCCCCCCCCCCCCEE		22.2422369663
680PhosphorylationRTNSFVGTEEYIAPE
CCCCCCCCCEECCCC		21.9722369663
683PhosphorylationSFVGTEEYIAPEVIR
CCCCCCEECCCCHHC		8.9922890988
815PhosphorylationSNKKRQTSQDSHKHL
CCCCCCCCHHHHHHH		24.5328889911
818PhosphorylationKRQTSQDSHKHLDEQ
CCCCCHHHHHHHHHH		27.1430377154
875PhosphorylationNSYGKIAYTPNSNRS
CCCCEEEECCCCCCC		26.6324961812
876PhosphorylationSYGKIAYTPNSNRSR
CCCEEEECCCCCCCC		13.6329136822
879PhosphorylationKIAYTPNSNRSRSNS
EEEECCCCCCCCCCC		34.5219684113
882PhosphorylationYTPNSNRSRSNSHRT
ECCCCCCCCCCCCCC		44.2928152593
884PhosphorylationPNSNRSRSNSHRTFF
CCCCCCCCCCCCCCC		43.8821440633
886PhosphorylationSNRSRSNSHRTFFKR
CCCCCCCCCCCCCCC		18.6521440633
889PhosphorylationSRSNSHRTFFKR---
CCCCCCCCCCCC---		28.1824961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FPK1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FPK1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FPK1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VHC1_YEASTVHC1physical
16554755
HPR1_YEASTHPR1physical
16554755
FUS3_YEASTFUS3genetic
19269370
YPD1_YEASTYPD1genetic
19269370
MNN10_YEASTMNN10genetic
19269370
VPS72_YEASTVPS72genetic
19269370
ISC1_YEASTISC1genetic
19269370
RPN10_YEASTRPN10genetic
19269370
PDK1_YEASTPKP1genetic
19269370
FAR1_YEASTFAR1genetic
19269370
RIC1_YEASTRIC1genetic
19269370
SWI6_YEASTSWI6genetic
19269370
YPT6_YEASTYPT6genetic
19269370
SEC22_YEASTSEC22genetic
19269370
VPS71_YEASTVPS71genetic
19269370
DSS1_YEASTDSS1genetic
19269370
YPK1_YEASTYPK1physical
19966303
IOC3_YEASTIOC3physical
20489023
NU157_YEASTNUP157physical
20489023
SOG2_YEASTSOG2physical
20489023
SYP1_YEASTSYP1physical
20489023
CTK3_YEASTCTK3genetic
21127252
BUB1_YEASTBUB1genetic
21127252
REI1_YEASTREI1genetic
21127252
RSC2_YEASTRSC2genetic
21127252
PACC_YEASTRIM101genetic
21127252
CLA4_YEASTCLA4genetic
21127252
CBF1_YEASTCBF1genetic
21127252
SKN7_YEASTSKN7genetic
21127252
TDA9_YEASTTDA9genetic
21127252
FUS3_YEASTFUS3genetic
21127252
AFT1_YEASTAFT1genetic
21127252
MDS3_YEASTMDS3genetic
21127252
SSN8_YEASTSSN8genetic
21127252
HAL4_YEASTSAT4genetic
21127252
KCS1_YEASTKCS1genetic
21127252
DCC1_YEASTDCC1genetic
21127252
PAU21_YEASTPAU21genetic
22282571
PAU22_YEASTPAU21genetic
22282571
YCT1_YEASTYCT1genetic
22282571
ELP2_YEASTELP2genetic
22282571
STE50_YEASTSTE50genetic
22282571
ELO2_YEASTELO2genetic
22282571
KRE28_YEASTKRE28genetic
22282571
EAF1_YEASTEAF1genetic
22282571
AP1_YEASTYAP1genetic
24462291
KIN82_YEASTKIN82genetic
25378585
KIN82_YEASTKIN82genetic
25724885
YPK1_YEASTYPK1physical
24510621
KIN82_YEASTKIN82genetic
24510621
ACT_YEASTACT1genetic
25253719
ROM2_YEASTROM2genetic
25253719
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
GGPPS_YEASTBTS1genetic
27708008
LTE1_YEASTLTE1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
AGP1_YEASTAGP1genetic
27708008
THRC_YEASTTHR4genetic
27708008
MED5_YEASTNUT1genetic
27708008
ELP2_YEASTELP2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
ARV1_YEASTARV1genetic
27708008
ADE_YEASTAAH1genetic
27708008
PTPA2_YEASTRRD2genetic
27708008
AKL1_YEASTAKL1physical
28069741
ART5_YEASTART5genetic
25781026
ATC5_YEASTDNF1genetic
25646086
ATC4_YEASTDNF2genetic
25646086
CDC42_YEASTCDC42genetic
25646086
CDC24_YEASTCDC24genetic
25646086
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FPK1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-175; SER-185;SER-200; SER-263; SER-300; SER-303; THR-335; SER-339; SER-414;SER-426; SER-462; THR-674; SER-676; THR-680 AND THR-876, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-339, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-414, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-676, AND MASSSPECTROMETRY.

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