YND1_YEAST - dbPTM
YND1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YND1_YEAST
UniProt AC P40009
Protein Name Golgi apyrase
Gene Name YND1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 630
Subcellular Localization Golgi apparatus . Membrane
Single-pass membrane protein .
Protein Description Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis..
Protein Sequence MLIENTNDRFGIVIDAGSSGSRIHVFKWQDTESLLHATNQDSQSILQSVPHIHQEKDWTFKLNPGLSSFEKKPQDAYKSHIKPLLDFAKNIIPESHWSSCPVFIQATAGMRLLPQDIQSSILDGLCQGLKHPAEFLVEDCSAQIQVIDGETEGLYGWLGLNYLYGHFNDYNPEVSDHFTFGFMDMGGASTQIAFAPHDSGEIARHRDDIATIFLRSVNGDLQKWDVFVSTWLGFGANQARRRYLAQLINTLPENTNDYENDDFSTRNLNDPCMPRGSSTDFEFKDTIFHIAGSGNYEQCTKSIYPLLLKNMPCDDEPCLFNGVHAPRIDFANDKFIGTSEYWYTANDVFKLGGEYNFDKFSKSLREFCNSNWTQILANSDKGVYNSIPENFLKDACFKGNWVLNILHEGFDMPRIDVDAENVNDRPLFQSVEKVEERELSWTLGRILLYASGSILAGNDDFMVGIAPSERRTKLTGKKFIPGKLLESDQLRKQSSSLSNKGFLMWFAIICCIFYLIFHRSHIIRRRFSGLYNITKDFKTGIRRRLKFLRRSDPFSRLEEGELGTDVDGFKDVYRMKSSSMFDLGKSSATMQREHEPQRTASQSANLAPSNLRPAFSMADFSKFKDSRLYD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
243PhosphorylationANQARRRYLAQLINT
HHHHHHHHHHHHHHH		12.4627017623
250PhosphorylationYLAQLINTLPENTND
HHHHHHHHCCCCCCC		36.3727017623
255PhosphorylationINTLPENTNDYENDD
HHHCCCCCCCCCCCC		28.0127017623
258PhosphorylationLPENTNDYENDDFST
CCCCCCCCCCCCCCC		20.7827017623
264PhosphorylationDYENDDFSTRNLNDP
CCCCCCCCCCCCCCC		33.1927017623
265PhosphorylationYENDDFSTRNLNDPC
CCCCCCCCCCCCCCC		24.4627017623
570UbiquitinationGTDVDGFKDVYRMKS
CCCCCCCHHHHCCCC		52.3823749301
576UbiquitinationFKDVYRMKSSSMFDL
CHHHHCCCCCCCCCC		37.8823749301
577PhosphorylationKDVYRMKSSSMFDLG
HHHHCCCCCCCCCCC		20.5022890988
578PhosphorylationDVYRMKSSSMFDLGK
HHHCCCCCCCCCCCC		21.9422890988
579PhosphorylationVYRMKSSSMFDLGKS
HHCCCCCCCCCCCCC		30.4722369663
585UbiquitinationSSMFDLGKSSATMQR
CCCCCCCCCHHHHHH		48.8423749301
586PhosphorylationSMFDLGKSSATMQRE
CCCCCCCCHHHHHHC		24.3325315811
587PhosphorylationMFDLGKSSATMQREH
CCCCCCCHHHHHHCC		31.1128889911
589PhosphorylationDLGKSSATMQREHEP
CCCCCHHHHHHCCCC		18.7828889911
599PhosphorylationREHEPQRTASQSANL
HCCCCCCCHHHHCCC		25.9722369663
601PhosphorylationHEPQRTASQSANLAP
CCCCCCHHHHCCCCC		24.8522369663
603PhosphorylationPQRTASQSANLAPSN
CCCCHHHHCCCCCCC		19.3422369663
609PhosphorylationQSANLAPSNLRPAFS
HHCCCCCCCCCCCCC		42.7823749301
616PhosphorylationSNLRPAFSMADFSKF
CCCCCCCCHHHHHHH		18.3721440633
621PhosphorylationAFSMADFSKFKDSRL
CCCHHHHHHHCCCCC		37.4227017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YND1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YND1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YND1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VATH_YEASTVMA13physical
10954728
GDA1_YEASTGDA1genetic
10409709
GDA1_YEASTGDA1genetic
16269340
ATC1_YEASTPMR1genetic
16269340
RUD3_YEASTRUD3genetic
16269340
ATC6_YEASTSPF1genetic
16269340
SCS7_YEASTSCS7genetic
16269340
SEC66_YEASTSEC66genetic
16269340
GET2_YEASTGET2genetic
16269340
ROT1_YEASTROT1genetic
16269340
COPE_YEASTSEC28genetic
16269340
TRS85_YEASTTRS85genetic
16269340
BIG1_YEASTBIG1genetic
16269340
TSC3_YEASTTSC3genetic
16269340
GYP1_YEASTGYP1genetic
16269340
PKR1_YEASTPKR1genetic
16269340
RTN1_YEASTRTN1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
YPQ2_YEASTYPQ2genetic
20093466
RTF1_YEASTRTF1genetic
20093466
HUR1_YEASTHUR1genetic
20093466
ATC1_YEASTPMR1genetic
20093466
MED5_YEASTNUT1genetic
20093466
PEX8_YEASTPEX8genetic
20093466
MED20_YEASTSRB2genetic
20093466
YUR1_YEASTYUR1genetic
20093466
MOG1_YEASTMOG1genetic
20093466
HOC1_YEASTHOC1genetic
20093466
SAC1_YEASTSAC1genetic
20093466
DCOR_YEASTSPE1genetic
20093466
SDHB_YEASTSDH2genetic
20093466
IRC20_YEASTIRC20genetic
20093466
RS3A1_YEASTRPS1Agenetic
20093466
GTR1_YEASTGTR1genetic
20093466
AIM36_YEASTAIM36genetic
20093466
MRE11_YEASTMRE11genetic
20093466
YN9A_YEASTYNR071Cgenetic
20093466
GYP1_YEASTGYP1genetic
20093466
WHI5_YEASTWHI5genetic
20093466
RUD3_YEASTRUD3genetic
20093466
AIM44_YEASTAIM44genetic
20093466
UBA3_YEASTUBA3genetic
20093466
MED1_YEASTMED1genetic
20093466
VCX1_YEASTVCX1physical
16093310
ERD1_YEASTERD1physical
16093310
PMP2_YEASTPMP2physical
16093310
VAM7_YEASTVAM7physical
16093310
ERV29_YEASTERV29physical
16093310
SYS1_YEASTSYS1physical
16093310
FRE1_YEASTFRE1physical
16093310
PRA1_YEASTYIP3physical
16093310
YP264_YEASTYPL264Cphysical
16093310
NU170_YEASTNUP170genetic
27708008
SGF29_YEASTSGF29genetic
27708008
GPR1_YEASTGPR1genetic
27708008
LIC4_YEASTATC1genetic
27708008
SND1_YEASTYDR186Cgenetic
27708008
MNN10_YEASTMNN10genetic
27708008
YPQ2_YEASTYPQ2genetic
27708008
COG7_YEASTCOG7genetic
27708008
MED5_YEASTNUT1genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
MED20_YEASTSRB2genetic
27708008
RL16A_YEASTRPL16Agenetic
27708008
ASF1_YEASTASF1genetic
27708008
YUR1_YEASTYUR1genetic
27708008
NUC1_YEASTNUC1genetic
27708008
CYC1_YEASTCYC1genetic
27708008
MOG1_YEASTMOG1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
ARPC3_YEASTARC18genetic
27708008
GTR1_YEASTGTR1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
PHO23_YEASTPHO23genetic
27708008
YN9A_YEASTYNR071Cgenetic
27708008
RUD3_YEASTRUD3genetic
27708008
HUT1_YEASTHUT1genetic
27708008
YP013_YEASTCMR3genetic
27708008
UBA3_YEASTUBA3genetic
27708008
MED1_YEASTMED1genetic
27708008
MSS18_YEASTMSS18genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YND1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579 AND SER-601, ANDMASS SPECTROMETRY.

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