VCX1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VCX1_YEAST
• UniProt AC: Q99385
• Protein Name: Vacuolar calcium ion transporter
• Gene Name: VCX1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 411
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein .
• Protein Description: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole..
• Protein Sequence: MDATTPLLTVANSHPARNPKHTAWRAAVYDLQYILKASPLNFLLVFVPLGLIWGHFQLSHTLTFLFNFLAIIPLAAILANATEELADKAGNTIGGLLNATFGNAVELIVSIIALKKGQVRIVQASMLGSLLSNLLLVLGLCFIFGGYNRVQQTFNQTAAQTMSSLLAIACASLLIPAAFRATLPHGKEDHFIDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTISRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVESTGLSKTFIGLIVIPIVGNAAEHVTSVLVAMKDKMDLALGVAIGSSLQVALFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGESNWLEGVMSLAMYILIAMAFFYYPDEKTLDSIGNSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDATTPLL -------CCCCCCCE	7.74	22814378
1	Oxidation	-------MDATTPLL -------CCCCCCCE	7.74	15665377
4	Phosphorylation	----MDATTPLLTVA ----CCCCCCCEECC	25.36	28132839
5	Phosphorylation	---MDATTPLLTVAN ---CCCCCCCEECCC	17.41	22369663
9	Phosphorylation	DATTPLLTVANSHPA CCCCCCEECCCCCCC	25.84	22369663
13	Phosphorylation	PLLTVANSHPARNPK CCEECCCCCCCCCCC	22.55	22369663
187	Acetylation	RATLPHGKEDHFIDG HHCCCCCCCCCCCCC	57.86	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VCX1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VCX1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VCX1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATC2_YEAST	PMC1	genetic	8668190
ATC2_YEAST	PMC1	genetic	15610534
ATC1_YEAST	PMR1	genetic	15610534
PHO88_YEAST	PHO88	physical	16093310
COS6_YEAST	COS6	physical	16093310
CTR1_YEAST	CTR1	physical	16093310
HSP72_YEAST	SSA2	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
ATC2_YEAST	PMC1	genetic	26055636
CANB_YEAST	CNB1	genetic	27100389

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION ATSER-13, AND MASS SPECTROMETRY.
PubMed: 15665377

Phosphorylation

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION ATSER-13, AND MASS SPECTROMETRY.
PubMed: 15665377