COS6_YEAST - dbPTM
COS6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COS6_YEAST
UniProt AC P53344
Protein Name Protein COS6
Gene Name COS6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 381
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description
Protein Sequence MKENELKNEKSVDVLSVKQLESQKTVLPQDLFRSSFTWFCYEIYKSLVFRIWMLLWLPLSVWWKLSNNWIYPLMVSLLVLFWGPVFVLVIFRLSRKRSLSKQLTQFCKEITKNTPSSDPHDWEVVAANLNSYFYENKAWNTKYFFFSAMSCQEAFRTTLLEPFSLKKDEAAKVKSFKDSVPYIEEALEVYFTEVEKQWKLFNSEKSWSPVGLEDAKLPKEAYRFKLTWVLKRIFNRRCLPLFLFYLHNVFISRNDGTIARPLFLVVLFFIMTRDFRNMRMIVLSVKMEHKMQFLSTIINEQESGANGWDEIAKKMNRYLFEKKVWKNEEFFFDGIDCEWFFSHFFYRVLSAKKSMRALSLNVELWPYIKEAQLSCSEESLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Ubiquitination-MKENELKNEKSVDV
-CCHHHCCCCCCCCE		57.8124961812
10UbiquitinationENELKNEKSVDVLSV
HHHCCCCCCCCEEEH		66.2423749301
11PhosphorylationNELKNEKSVDVLSVK
HHCCCCCCCCEEEHH		19.8521551504
16PhosphorylationEKSVDVLSVKQLESQ
CCCCCEEEHHHHHHC		27.4122369663
18UbiquitinationSVDVLSVKQLESQKT
CCCEEEHHHHHHCCC		45.8723749301
199UbiquitinationTEVEKQWKLFNSEKS
HHHHHHHHHHCCCCC		40.4823749301
205UbiquitinationWKLFNSEKSWSPVGL
HHHHCCCCCCCCCCH		57.9823749301
216UbiquitinationPVGLEDAKLPKEAYR
CCCHHCCCCCHHHHH		77.1023749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COS6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COS6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COS6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MST27_YEASTMST27physical
16093310
MKAR_YEASTIFA38physical
16093310
ELO2_YEASTELO2physical
16093310
SHR3_YEASTSHR3physical
16093310
SHO1_YEASTSHO1physical
16093310
AUR1_YEASTAUR1physical
16093310
THI7_YEASTTHI7physical
16093310
GAS2_YEASTGAS2physical
16093310
ELO3_YEASTELO3physical
16093310
GSF2_YEASTGSF2physical
16093310
FMP42_YEASTYMR221Cphysical
16093310
ATX2_YEASTATX2physical
16093310
AQY1_YEASTAQY1physical
16093310
RSP5_YEASTRSP5physical
25942624
HAP5_YEASTHAP5genetic
27708008
SNU56_YEASTSNU56genetic
27708008
DAM1_YEASTDAM1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
DNA2_YEASTDNA2genetic
27708008
MOB1_YEASTMOB1genetic
27708008
FNTA_YEASTRAM2genetic
27708008
VTI1_YEASTVTI1genetic
27708008
ROT1_YEASTROT1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
URA7_YEASTURA7genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
SHG1_YEASTSHG1genetic
27708008
IMG2_YEASTIMG2genetic
27708008
VAM6_YEASTVAM6genetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
RRP8_YEASTRRP8genetic
27708008
TMN3_YEASTTMN3genetic
27708008
RAD4_YEASTRAD4genetic
27708008
NMA2_YEASTNMA2genetic
27708008
CSK21_YEASTCKA1genetic
27708008
HPM1_YEASTHPM1genetic
27708008
DHOM_YEASTHOM6genetic
27708008
FABG_YEASTOAR1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
NAP1_YEASTNAP1genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
STM1_YEASTSTM1genetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
ERG2_YEASTERG2genetic
27708008
RS10B_YEASTRPS10Bgenetic
27708008
TPM1_YEASTTPM1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
PFD4_YEASTGIM3genetic
27708008
CUZ1_YEASTCUZ1genetic
27708008
CSI2_YEASTCSI2genetic
27708008
INO4_YEASTINO4genetic
27708008
RDL1_YEASTRDL1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
COX10_YEASTCOX10genetic
27708008
RU2A_YEASTLEA1genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COS6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.

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