HEM2_YEAST - dbPTM
HEM2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HEM2_YEAST
UniProt AC P05373
Protein Name Delta-aminolevulinic acid dehydratase
Gene Name HEM2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 342
Subcellular Localization
Protein Description Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen..
Protein Sequence MHTAEFLETEPTEISSVLAGGYNHPLLRQWQSERQLTKNMLIFPLFISDNPDDFTEIDSLPNINRIGVNRLKDYLKPLVAKGLRSVILFGVPLIPGTKDPVGTAADDPAGPVIQGIKFIREYFPELYIICDVCLCEYTSHGHCGVLYDDGTINRERSVSRLAAVAVNYAKAGAHCVAPSDMIDGRIRDIKRGLINANLAHKTFVLSYAAKFSGNLYGPFRDAACSAPSNGDRKCYQLPPAGRGLARRALERDMSEGADGIIVKPSTFYLDIMRDASEICKDLPICAYHVSGEYAMLHAAAEKGVVDLKTIAFESHQGFLRAGARLIITYLAPEFLDWLDEEN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
76AcetylationNRLKDYLKPLVAKGL
HHHHHHHHHHHHHCC		30.0324489116
170UbiquitinationAVAVNYAKAGAHCVA
HHHHHHHHCCCEEEC		36.6723749301
225PhosphorylationPFRDAACSAPSNGDR
CCCCCCCCCCCCCCC		38.1928889911
254PhosphorylationRALERDMSEGADGII
HHHHHHHCCCCCEEE		36.8522369663
263UbiquitinationGADGIIVKPSTFYLD
CCCEEEECCCEEHHH		23.8923749301
265PhosphorylationDGIIVKPSTFYLDIM
CEEEECCCEEHHHHH		25.9822369663
266PhosphorylationGIIVKPSTFYLDIMR
EEEECCCEEHHHHHC		25.4822369663
268PhosphorylationIVKPSTFYLDIMRDA
EECCCEEHHHHHCCH		11.9822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HEM2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HEM2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HEM2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HEM2_YEASTHEM2physical
11283351
HEM2_YEASTHEM2physical
18467557
YAJ9_YEASTYAR029Wgenetic
20093466
CLPX_YEASTMCX1genetic
20093466
YCY0_YEASTYCR090Cgenetic
20093466
RXT3_YEASTRXT3genetic
20093466
NHP10_YEASTNHP10genetic
20093466
VPS41_YEASTVPS41genetic
20093466
ODO2_YEASTKGD2genetic
20093466
DHAS_YEASTHOM2genetic
20093466
SSD1_YEASTSSD1genetic
20093466
XRS2_YEASTXRS2genetic
20093466
AK_YEASTHOM3genetic
20093466
METE_YEASTMET6genetic
20093466
CBP4_YEASTCBP4genetic
20093466
LPLA_YEASTAIM22genetic
20093466
DHOM_YEASTHOM6genetic
20093466
FEN1_YEASTRAD27genetic
20093466
FABG_YEASTOAR1genetic
20093466
YL415_YEASTYLR415Cgenetic
20093466
CDC73_YEASTCDC73genetic
20093466
SAM37_YEASTSAM37genetic
20093466
GBLP_YEASTASC1genetic
20093466
SIW14_YEASTSIW14genetic
20093466
ARE2_YEASTARE2genetic
20093466
SKM1_YEASTSKM1genetic
20093466
MDM12_YEASTMDM12genetic
20093466
PHO80_YEASTPHO80genetic
20093466
GYP1_YEASTGYP1genetic
20093466
LEO1_YEASTLEO1genetic
20093466
LIPA_YEASTLIP5genetic
20093466
PNT1_YEASTPNT1genetic
20093466
MED1_YEASTMED1genetic
20093466
ELO3_YEASTELO3genetic
21623372
CSG2_YEASTCSG2genetic
21623372
MET22_YEASTMET22genetic
21623372
AATC_YEASTAAT2genetic
21623372
PDX3_YEASTPDX3genetic
21623372
AK_YEASTHOM3genetic
21623372
CEM1_YEASTCEM1genetic
21623372
CY1_YEASTCYT1genetic
21623372
CBS_YEASTCYS4genetic
21623372
METX_YEASTYML082Wgenetic
21623372
ODO2_YEASTKGD2genetic
21623372
6PGD1_YEASTGND1genetic
21623372
CYS3_YEASTCYS3genetic
21623372
PPT2_YEASTPPT2genetic
21623372
KCS1_YEASTKCS1genetic
21623372
THRC_YEASTTHR4genetic
21623372
ARE1_YEASTARE1genetic
21623372
TGL2_YEASTTGL2genetic
21623372
AMPD_YEASTAMD1genetic
21623372
ELO1_YEASTELO1genetic
21623372
HEM3_YEASTHEM3genetic
14559249
HEM4_YEASTHEM4genetic
14559249
DCUP_YEASTHEM12genetic
14559249
DAP1_YEASTDAP1genetic
17954932
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HEM2_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory