PNT1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PNT1_YEAST
• UniProt AC: P38969
• Protein Name: Pentamidine resistance factor, mitochondrial
• Gene Name: PNT1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 423
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Probably involved in mitochondrial export. Confers resistance to the anti-pneumocystis carinii drug pentamidine. May act by the removal of pentamidine, or its damage targets, from the matrix by an active-transport mechanism..
• Protein Sequence: MDSRVALVRKYIAPSVIKSDSIQLHGLVKAPLFKALNSRYKLGSLQIVQDVDWNAKTTPSDSPEPLAATLNSNRSLPMTKFPKQEILEQVKLDTKVGKWRKFMTGWFRIGLYLLKSYKTGIQNTLKVFWDTRNEEQKFSIKNGALANLVREIEMHEINTRLSSSSLPTSSSAKAPLRPLSINRKTLVELIRRDQIWKLPVFFTLVFIFEEVSVLIFTFFPRVCPYNCLTPGGYKKLSNSYIKGTTSTQGNYGLGPLEFTKQGTIKYEPPYAVPIENLYNFLTSFPQSMISNWKLYIYKKLKLQKLLCNEIEKIYQYLFIDDWLLLQSILNTDVEKTKIALSDRELVNCILERKLYHMGDDLNEMVNDTLGKEILLKRLFLYWTLRYNDTISLNGKHTFSEKWGVNNISLLKYNSELVATKDIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RVALVRKYIAPSVIK HHHHHHHHHCCHHCC	7.55	28889911
15	Phosphorylation	VRKYIAPSVIKSDSI HHHHHCCHHCCCCCE	27.70	28889911
246	Phosphorylation	SYIKGTTSTQGNYGL CEECCCCCCCCCCCC	20.69	28889911
251	Phosphorylation	TTSTQGNYGLGPLEF CCCCCCCCCCCCEEE	22.13	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PNT1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PNT1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PNT1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COX18_YEAST	COX18	genetic	11950926
SWD1_YEAST	SWD1	genetic	20093466
SCO2_YEAST	SCO2	genetic	20093466
YCA2_YEAST	YCL002C	genetic	20093466
CRD1_YEAST	CRD1	genetic	20093466
UBX3_YEAST	UBX3	genetic	20093466
SLX5_YEAST	SLX5	genetic	20093466
TRM82_YEAST	TRM82	genetic	20093466
ERD1_YEAST	ERD1	genetic	20093466
SGF73_YEAST	SGF73	genetic	20093466
NPR3_YEAST	NPR3	genetic	20093466
MED20_YEAST	SRB2	genetic	20093466
LSM12_YEAST	LSM12	genetic	20093466
THIK_YEAST	POT1	genetic	20093466
SNX4_YEAST	SNX4	genetic	20093466
MOG1_YEAST	MOG1	genetic	20093466
YJ90_YEAST	YJR120W	genetic	20093466
SAC1_YEAST	SAC1	genetic	20093466
IXR1_YEAST	IXR1	genetic	20093466
EMC6_YEAST	EMC6	genetic	20093466
RCF1_YEAST	RCF1	genetic	20093466
ERG6_YEAST	ERG6	genetic	20093466
YPK2_YEAST	YPK2	genetic	20093466
COA6_YEAST	COA6	genetic	20093466
COX7_YEAST	COX7	genetic	20093466
YME2_YEAST	YME2	genetic	20093466
YNB0_YEAST	YNL010W	genetic	20093466
VPS27_YEAST	VPS27	genetic	20093466
IRA2_YEAST	IRA2	genetic	20093466
RU2A_YEAST	LEA1	genetic	20093466
TGS1_YEAST	TGS1	genetic	20093466
KTR6_YEAST	KTR6	genetic	20093466
CISY3_YEAST	CIT3	genetic	20093466
YP089_YEAST	YPR089W	genetic	20093466
HPA2_YEAST	HPA2	genetic	20093466
SSB1_YEAST	SSB1	physical	22940862
RV161_YEAST	RVS161	genetic	27708008
CRD1_YEAST	CRD1	genetic	27708008
FTHC_YEAST	FAU1	genetic	27708008
NPR3_YEAST	NPR3	genetic	27708008
RL17B_YEAST	RPL17B	genetic	27708008
MRT4_YEAST	MRT4	genetic	27708008
IXR1_YEAST	IXR1	genetic	27708008
CTK1_YEAST	CTK1	genetic	27708008
ERG6_YEAST	ERG6	genetic	27708008
YPK2_YEAST	YPK2	genetic	27708008
COA6_YEAST	COA6	genetic	27708008
SIN3_YEAST	SIN3	genetic	27708008
MDM12_YEAST	MDM12	genetic	27708008
IRA2_YEAST	IRA2	genetic	27708008
VPS4_YEAST	VPS4	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.