HEM3_YEAST - dbPTM
HEM3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HEM3_YEAST
UniProt AC P28789
Protein Name Porphobilinogen deaminase
Gene Name HEM3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 327
Subcellular Localization
Protein Description Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps..
Protein Sequence MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMACGKILAERMIADGAKKILDEINLDRIK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
55PhosphorylationIQFKPLYSFGGKALW
CCEEECEEECCEEEE
25.7130377154
85PhosphorylationKLDLIVHSLKDMPTL
HHHEEECCCCCCCCC
26.6419795423
109PhosphorylationITKRVDPTDCLVMPF
CCCCCCHHCCEEECC
34.5827017623
117PhosphorylationDCLVMPFYSAYKSLD
CCEEECCHHHHHCCC
6.1127017623
120PhosphorylationVMPFYSAYKSLDDLP
EECCHHHHHCCCCCC
8.6527017623
147PhosphorylationSAQLKRKYPHLKFES
HHHHHHHCCCCCHHH
10.4221126336
171PhosphorylationQKLDDPKSPYQCIIL
HHCCCCCCHHHHHHH
33.9427017623
173PhosphorylationLDDPKSPYQCIILAS
CCCCCCHHHHHHHHC
24.0927017623
198PhosphorylationRITQRFHSDTMYHAV
CHHHHCCCCCHHHHC
31.8728889911
251S-(dipyrrolylmethanemethyl)cysteineMRTLEGGCSVPIGVE
HHHHHCCCCCCCCCC
5.65-
251PyrrolylationMRTLEGGCSVPIGVE
HHHHHCCCCCCCCCC
5.65-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HEM3_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HEM3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HEM3_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FUMH_YEASTFUM1genetic
21623372
6PGD1_YEASTGND1genetic
21623372
ARGJ_YEASTARG7genetic
21623372
CSG2_YEASTCSG2genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
INP53_YEASTINP53genetic
21623372
GUP1_YEASTGUP1genetic
21623372
ELO3_YEASTELO3genetic
21623372
HEM4_YEASTHEM4genetic
14559249
DCUP_YEASTHEM12genetic
14559249

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HEM3_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP