UniProt ID | HEM3_YEAST | |
---|---|---|
UniProt AC | P28789 | |
Protein Name | Porphobilinogen deaminase | |
Gene Name | HEM3 | |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
Sequence Length | 327 | |
Subcellular Localization | ||
Protein Description | Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.. | |
Protein Sequence | MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMACGKILAERMIADGAKKILDEINLDRIK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
55 | Phosphorylation | IQFKPLYSFGGKALW CCEEECEEECCEEEE | 25.71 | 30377154 | |
85 | Phosphorylation | KLDLIVHSLKDMPTL HHHEEECCCCCCCCC | 26.64 | 19795423 | |
109 | Phosphorylation | ITKRVDPTDCLVMPF CCCCCCHHCCEEECC | 34.58 | 27017623 | |
117 | Phosphorylation | DCLVMPFYSAYKSLD CCEEECCHHHHHCCC | 6.11 | 27017623 | |
120 | Phosphorylation | VMPFYSAYKSLDDLP EECCHHHHHCCCCCC | 8.65 | 27017623 | |
147 | Phosphorylation | SAQLKRKYPHLKFES HHHHHHHCCCCCHHH | 10.42 | 21126336 | |
171 | Phosphorylation | QKLDDPKSPYQCIIL HHCCCCCCHHHHHHH | 33.94 | 27017623 | |
173 | Phosphorylation | LDDPKSPYQCIILAS CCCCCCHHHHHHHHC | 24.09 | 27017623 | |
198 | Phosphorylation | RITQRFHSDTMYHAV CHHHHCCCCCHHHHC | 31.87 | 28889911 | |
251 | S-(dipyrrolylmethanemethyl)cysteine | MRTLEGGCSVPIGVE HHHHHCCCCCCCCCC | 5.65 | - | |
251 | Pyrrolylation | MRTLEGGCSVPIGVE HHHHHCCCCCCCCCC | 5.65 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEM3_YEAST !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEM3_YEAST !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEM3_YEAST !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
FUMH_YEAST | FUM1 | genetic | 21623372 | |
6PGD1_YEAST | GND1 | genetic | 21623372 | |
ARGJ_YEAST | ARG7 | genetic | 21623372 | |
CSG2_YEAST | CSG2 | genetic | 21623372 | |
PFKA1_YEAST | PFK1 | genetic | 21623372 | |
INP53_YEAST | INP53 | genetic | 21623372 | |
GUP1_YEAST | GUP1 | genetic | 21623372 | |
ELO3_YEAST | ELO3 | genetic | 21623372 | |
HEM4_YEAST | HEM4 | genetic | 14559249 | |
DCUP_YEAST | HEM12 | genetic | 14559249 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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