| UniProt ID | HEM3_YEAST | |
|---|---|---|
| UniProt AC | P28789 | |
| Protein Name | Porphobilinogen deaminase | |
| Gene Name | HEM3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 327 | |
| Subcellular Localization | ||
| Protein Description | Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.. | |
| Protein Sequence | MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMACGKILAERMIADGAKKILDEINLDRIK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 55 | Phosphorylation | IQFKPLYSFGGKALW CCEEECEEECCEEEE | 25.71 | 30377154 | |
| 85 | Phosphorylation | KLDLIVHSLKDMPTL HHHEEECCCCCCCCC | 26.64 | 19795423 | |
| 109 | Phosphorylation | ITKRVDPTDCLVMPF CCCCCCHHCCEEECC | 34.58 | 27017623 | |
| 117 | Phosphorylation | DCLVMPFYSAYKSLD CCEEECCHHHHHCCC | 6.11 | 27017623 | |
| 120 | Phosphorylation | VMPFYSAYKSLDDLP EECCHHHHHCCCCCC | 8.65 | 27017623 | |
| 147 | Phosphorylation | SAQLKRKYPHLKFES HHHHHHHCCCCCHHH | 10.42 | 21126336 | |
| 171 | Phosphorylation | QKLDDPKSPYQCIIL HHCCCCCCHHHHHHH | 33.94 | 27017623 | |
| 173 | Phosphorylation | LDDPKSPYQCIILAS CCCCCCHHHHHHHHC | 24.09 | 27017623 | |
| 198 | Phosphorylation | RITQRFHSDTMYHAV CHHHHCCCCCHHHHC | 31.87 | 28889911 | |
| 251 | S-(dipyrrolylmethanemethyl)cysteine | MRTLEGGCSVPIGVE HHHHHCCCCCCCCCC | 5.65 | - | |
| 251 | Pyrrolylation | MRTLEGGCSVPIGVE HHHHHCCCCCCCCCC | 5.65 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEM3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEM3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEM3_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FUMH_YEAST | FUM1 | genetic | 21623372 | |
| 6PGD1_YEAST | GND1 | genetic | 21623372 | |
| ARGJ_YEAST | ARG7 | genetic | 21623372 | |
| CSG2_YEAST | CSG2 | genetic | 21623372 | |
| PFKA1_YEAST | PFK1 | genetic | 21623372 | |
| INP53_YEAST | INP53 | genetic | 21623372 | |
| GUP1_YEAST | GUP1 | genetic | 21623372 | |
| ELO3_YEAST | ELO3 | genetic | 21623372 | |
| HEM4_YEAST | HEM4 | genetic | 14559249 | |
| DCUP_YEAST | HEM12 | genetic | 14559249 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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