| UniProt ID | PRK1_YEAST | |
|---|---|---|
| UniProt AC | P40494 | |
| Protein Name | Actin-regulating kinase PRK1 | |
| Gene Name | PRK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 810 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, actin patch . Cortical actin patches. | |
| Protein Description | Involved in regulation of actin cytoskeleton organization and endocytosis.. | |
| Protein Sequence | MNTPQISLYEPGTILTVGSHHAKIIKYLTSGGFAQVYTAEISPPDPYSNANIACLKRVIVPHKQGLNTLRAEVDAMKLLRNNKHVVSYIDSHAARSVNGIAYEVFVLMEFCERGGLIDFMNTRLQNRLQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRNTQEFNYVQHDILTNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGEAGILHARYQYPSFPQYSDRLKNLIRLMLMEAPSQRPNICQVLEEVSRLQNKPCPIRNFYLLRAMNQNANTQLAGEPSSTTYVPTQKFIPVQSLQSINQPPNMMPVTHVSTTPNLGTFPISINDNNKTEVTAHAGLQVGSHSNLTSPLMKTKSVPLSDEFASLYYKELHPFQKSQTFKSVESFQSPQRKSMPPLSLTPVNNDIFDRVSAINRPNNYVDSETQTIDNMAVPNLKLSPTITSKSLSSTKEIAAPDNINGSKIVRSLSSKLKKVITGESRGNSPIKSRQNTGDSIRSAFGKLRHGFTGNSVNNSRSASFDNNNVNGNGNNTNRRLVSSSTSSFPKFNSDTKRKEESDKNQRLEKRRSMPPSILSDFDQHERNNSRTGSRDYYRSHSPVKKTQASAKTTSKPTLIPDNGNVNINQEKKESIQRRVHNLLKSSDDPVTYKSASGYGKYTDIGTETSNRHSSVRITPITEEKFKKTLKDGVLDIKTKSNGKDKSRPPRPPPKPLHLRTEIQKIRNFSRLQSKKLPIERISSEATETIVDVNVDDLEADFRKRFPSKV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 77 | Acetylation | RAEVDAMKLLRNNKH HHHHHHHHHHHCCCC | 46.20 | 25381059 | |
| 248 | Phosphorylation | YTTPFEKSGEAGILH HCCCCCCCCCCEEEE | 34.37 | 25315811 | |
| 309 | Phosphorylation | PCPIRNFYLLRAMNQ CCCHHHHHHHHHHHC | 14.36 | 29650682 | |
| 389 | Phosphorylation | HAGLQVGSHSNLTSP CCCCCCCCCCCCCCC | 25.53 | 20377248 | |
| 391 | Phosphorylation | GLQVGSHSNLTSPLM CCCCCCCCCCCCCCC | 34.92 | 24961812 | |
| 394 | Phosphorylation | VGSHSNLTSPLMKTK CCCCCCCCCCCCCCC | 32.33 | 24961812 | |
| 395 | Phosphorylation | GSHSNLTSPLMKTKS CCCCCCCCCCCCCCC | 21.14 | 28889911 | |
| 400 | Phosphorylation | LTSPLMKTKSVPLSD CCCCCCCCCCCCCCH | 18.00 | 22369663 | |
| 402 | Phosphorylation | SPLMKTKSVPLSDEF CCCCCCCCCCCCHHH | 33.91 | 22369663 | |
| 406 | Phosphorylation | KTKSVPLSDEFASLY CCCCCCCCHHHHHHH | 29.08 | 22369663 | |
| 423 | Phosphorylation | ELHPFQKSQTFKSVE HHCCCCCCCCCCCHH | 24.54 | 19823750 | |
| 425 | Phosphorylation | HPFQKSQTFKSVESF CCCCCCCCCCCHHHC | 39.87 | 29136822 | |
| 428 | Phosphorylation | QKSQTFKSVESFQSP CCCCCCCCHHHCCCC | 27.25 | 22369663 | |
| 431 | Phosphorylation | QTFKSVESFQSPQRK CCCCCHHHCCCCCCC | 26.82 | 22369663 | |
| 434 | Phosphorylation | KSVESFQSPQRKSMP CCHHHCCCCCCCCCC | 22.46 | 22369663 | |
| 439 | Phosphorylation | FQSPQRKSMPPLSLT CCCCCCCCCCCCCCC | 38.42 | 28889911 | |
| 444 | Phosphorylation | RKSMPPLSLTPVNND CCCCCCCCCCCCCCC | 35.65 | 27017623 | |
| 446 | Phosphorylation | SMPPLSLTPVNNDIF CCCCCCCCCCCCCHH | 23.09 | 29734811 | |
| 468 | Phosphorylation | RPNNYVDSETQTIDN CCCCCCCCCCCEECC | 32.28 | 22369663 | |
| 470 | Phosphorylation | NNYVDSETQTIDNMA CCCCCCCCCEECCCC | 34.66 | 22369663 | |
| 472 | Phosphorylation | YVDSETQTIDNMAVP CCCCCCCEECCCCCC | 37.40 | 22369663 | |
| 484 | Phosphorylation | AVPNLKLSPTITSKS CCCCCEECCCCCCCC | 20.57 | 22369663 | |
| 486 | Phosphorylation | PNLKLSPTITSKSLS CCCEECCCCCCCCCC | 33.25 | 22369663 | |
| 488 | Phosphorylation | LKLSPTITSKSLSST CEECCCCCCCCCCCC | 32.36 | 22369663 | |
| 489 | Phosphorylation | KLSPTITSKSLSSTK EECCCCCCCCCCCCC | 19.18 | 22369663 | |
| 491 | Phosphorylation | SPTITSKSLSSTKEI CCCCCCCCCCCCCCC | 33.00 | 23749301 | |
| 493 | Phosphorylation | TITSKSLSSTKEIAA CCCCCCCCCCCCCCC | 42.95 | 21440633 | |
| 494 | Phosphorylation | ITSKSLSSTKEIAAP CCCCCCCCCCCCCCC | 49.11 | 21440633 | |
| 495 | Phosphorylation | TSKSLSSTKEIAAPD CCCCCCCCCCCCCCC | 29.35 | 21440633 | |
| 507 | Phosphorylation | APDNINGSKIVRSLS CCCCCCHHHHHHHHH | 18.08 | 25704821 | |
| 512 | Phosphorylation | NGSKIVRSLSSKLKK CHHHHHHHHHHHCCH | 23.00 | 19823750 | |
| 514 | Phosphorylation | SKIVRSLSSKLKKVI HHHHHHHHHHCCHHH | 27.03 | 21440633 | |
| 515 | Phosphorylation | KIVRSLSSKLKKVIT HHHHHHHHHCCHHHC | 47.50 | 21440633 | |
| 522 | Phosphorylation | SKLKKVITGESRGNS HHCCHHHCCCCCCCC | 37.57 | 22369663 | |
| 525 | Phosphorylation | KKVITGESRGNSPIK CHHHCCCCCCCCCCC | 47.00 | 22369663 | |
| 529 | Phosphorylation | TGESRGNSPIKSRQN CCCCCCCCCCCCCCC | 30.72 | 22890988 | |
| 533 | Phosphorylation | RGNSPIKSRQNTGDS CCCCCCCCCCCCHHH | 39.56 | 22369663 | |
| 537 | Phosphorylation | PIKSRQNTGDSIRSA CCCCCCCCHHHHHHH | 33.74 | 20377248 | |
| 540 | Phosphorylation | SRQNTGDSIRSAFGK CCCCCHHHHHHHHHH | 22.65 | 22369663 | |
| 543 | Phosphorylation | NTGDSIRSAFGKLRH CCHHHHHHHHHHHHC | 26.70 | 22369663 | |
| 553 | Phosphorylation | GKLRHGFTGNSVNNS HHHHCCCCCCCCCCC | 39.79 | 22369663 | |
| 556 | Phosphorylation | RHGFTGNSVNNSRSA HCCCCCCCCCCCCCC | 27.80 | 22369663 | |
| 560 | Phosphorylation | TGNSVNNSRSASFDN CCCCCCCCCCCCCCC | 23.55 | 22369663 | |
| 562 | Phosphorylation | NSVNNSRSASFDNNN CCCCCCCCCCCCCCC | 28.25 | 22369663 | |
| 564 | Phosphorylation | VNNSRSASFDNNNVN CCCCCCCCCCCCCCC | 34.09 | 22369663 | |
| 583 | Phosphorylation | NTNRRLVSSSTSSFP CCCCCCCCCCCCCCC | 24.14 | 22369663 | |
| 584 | Phosphorylation | TNRRLVSSSTSSFPK CCCCCCCCCCCCCCC | 30.10 | 22369663 | |
| 585 | Phosphorylation | NRRLVSSSTSSFPKF CCCCCCCCCCCCCCC | 25.46 | 22369663 | |
| 586 | Phosphorylation | RRLVSSSTSSFPKFN CCCCCCCCCCCCCCC | 30.27 | 22369663 | |
| 587 | Phosphorylation | RLVSSSTSSFPKFNS CCCCCCCCCCCCCCC | 31.74 | 22369663 | |
| 588 | Phosphorylation | LVSSSTSSFPKFNSD CCCCCCCCCCCCCCC | 45.73 | 22369663 | |
| 591 | Acetylation | SSTSSFPKFNSDTKR CCCCCCCCCCCCCCC | 55.99 | 22865919 | |
| 613 | Phosphorylation | QRLEKRRSMPPSILS HHHHHHHCCCHHHHC | 39.41 | 17330950 | |
| 617 | Phosphorylation | KRRSMPPSILSDFDQ HHHCCCHHHHCCCHH | 30.23 | 19779198 | |
| 695 | Phosphorylation | DDPVTYKSASGYGKY CCCCEEECCCCCCCC | 19.77 | 22890988 | |
| 697 | Phosphorylation | PVTYKSASGYGKYTD CCEEECCCCCCCCCC | 39.37 | 22890988 | |
| 699 | Phosphorylation | TYKSASGYGKYTDIG EEECCCCCCCCCCCC | 14.14 | 22890988 | |
| 701 | Acetylation | KSASGYGKYTDIGTE ECCCCCCCCCCCCCC | 36.17 | 24489116 | |
| 702 | Phosphorylation | SASGYGKYTDIGTET CCCCCCCCCCCCCCC | 12.79 | 22890988 | |
| 703 | Phosphorylation | ASGYGKYTDIGTETS CCCCCCCCCCCCCCC | 25.32 | 22890988 | |
| 707 | Phosphorylation | GKYTDIGTETSNRHS CCCCCCCCCCCCCCC | 36.10 | 22890988 | |
| 709 | Phosphorylation | YTDIGTETSNRHSSV CCCCCCCCCCCCCCE | 31.01 | 22890988 | |
| 710 | Phosphorylation | TDIGTETSNRHSSVR CCCCCCCCCCCCCEE | 26.15 | 22890988 | |
| 714 | Phosphorylation | TETSNRHSSVRITPI CCCCCCCCCEEEEEC | 27.56 | 21440633 | |
| 761 | Phosphorylation | PKPLHLRTEIQKIRN CCCCCHHHHHHHHHC | 43.74 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-400; SER-402; SER-428;SER-431; SER-484 AND THR-486, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-400; THR-522; SER-525;THR-553 AND SER-556, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540, AND MASSSPECTROMETRY. | |
