HPH2_YEAST - dbPTM
HPH2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HPH2_YEAST
UniProt AC P39734
Protein Name Protein HPH2
Gene Name FRT2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 528
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein . Punctate foci at the endoplasmic reticulum membrane.
Protein Description Required for growth under high NaCl, alkaline pH and cell wall stress..
Protein Sequence MQNAQIKSSSKGSGIDGTDRNSKDGVEKRPLEDVKQMIDAGTPDVGHKSTVETKPNVGWQASHSNLAALHEKEQKYEMEHHHARHKLHRQVIPDYTSASTAMFSDCMFNAAPDKVRSLSTMKSSGLSPKHPFNVVATFKGPFPQHSVESKPLDGGYSAKDHFPSFKMLQAQQHPAHRHYKDNDKYGLKSPSRSFVKDKKRLVHRFLKSMEPSSSGQSKDSSALAPAFDPILPNVISKPSKRPTHHSHSSDGSSSTQTDISLQSLLYHDLESSPKKHVSPSRPPSVASESSPAVANPIGLSPKDACNASFSQSSSSSLSSSSSSSSSTSFSQSVAVDPLEPPGNITYSSSNLSLNSDELDYYQRHIGLQLQQTEALLKHSLKDEVLKDENDLVKNIANFDKIVKELRDLRSRTIGWKELVEEDYLMNLKQDFDKENPESFEARLSDTINTNVAKLQDLEKRMASCKDRLASRKEVMRKMESLLSLENSLMISKKNVTFASKYRNEALDIVFLIIIIVICYTFKHLVSHK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationIKSSSKGSGIDGTDR
CCCCCCCCCCCCCCC		35.9928889911
62PhosphorylationPNVGWQASHSNLAAL
CCCCCCCCCCCHHHH		16.6120377248
64PhosphorylationVGWQASHSNLAALHE
CCCCCCCCCHHHHHH		30.9224961812
117PhosphorylationAAPDKVRSLSTMKSS
CCCHHHHCHHHHHHC		29.6521440633
164PhosphorylationSAKDHFPSFKMLQAQ
CHHHCCCCHHHHHHH		36.2321440633
208PhosphorylationLVHRFLKSMEPSSSG
HHHHHHHHCCCCCCC		30.4419779198
212PhosphorylationFLKSMEPSSSGQSKD
HHHHCCCCCCCCCCC		24.6719779198
213PhosphorylationLKSMEPSSSGQSKDS
HHHCCCCCCCCCCCH		49.5619779198
278PhosphorylationSSPKKHVSPSRPPSV
CCCCCCCCCCCCCCC		19.5124961812
280PhosphorylationPKKHVSPSRPPSVAS
CCCCCCCCCCCCCCC		50.3328889911
284PhosphorylationVSPSRPPSVASESSP
CCCCCCCCCCCCCCC		32.7619779198
287PhosphorylationSRPPSVASESSPAVA
CCCCCCCCCCCCCCC		35.5419779198
483PhosphorylationRKMESLLSLENSLMI
HHHHHHHCHHHHHHH		38.6427017623
487PhosphorylationSLLSLENSLMISKKN
HHHCHHHHHHHHCCC		15.2227017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HPH2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HPH2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HPH2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HIS7_YEASTHIS3genetic
19595784
SEC66_YEASTSEC66physical
21097665
SEC72_YEASTSEC72physical
21097665
SEC62_YEASTSEC62physical
21097665
SEC63_YEASTSEC63physical
21097665
SC61A_YEASTSEC61physical
21097665
PKR1_YEASTPKR1genetic
21097665
ATPG_YEASTATP3physical
22940862
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
SCC1_YEASTMCD1genetic
27708008
UAP1_YEASTQRI1genetic
27708008
SNU56_YEASTSNU56genetic
27708008
YHS2_YEASTCIA2genetic
27708008
SPC97_YEASTSPC97genetic
27708008
SDO1_YEASTSDO1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HPH2_YEAST

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Related Literatures of Post-Translational Modification

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